The DOI matches its Crossref record; 203 of the 203 references it cites were found in a registry or an index.
miRNA: A Promising Therapeutic Target in Cancer
Open accessAbstract
microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by complementarity pairing. Since discovery, they have been reported to be involved in a variety of biological functions and pathologies including cancer. In cancer, they can act as a tumor suppressor or oncomiR depending on the cell type. Studies have shown that miRNA-based therapy, either by inhibiting an oncomiR or by inducing a tumor suppressor, is effective in cancer treatment. This review focusses on the role of miRNA in cancer, therapeutic approaches with miRNAs and how they can be effectively delivered into a system. We have also summarized the patents and clinical trials in progress for miRNA therapy.
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2 retracted
Xiao, J., Yang, B., Lin, H., Lu, Y., Luo, X., & Wang, Z. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21062 · Cited by 193
RetractedmiR-122 Regulates Tumorigenesis in Hepatocellular Carcinoma by Targeting AKT3
Nassirpour, R., Mehta, P. P., & Yin, M.-J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079655 · Cited by 96
RetractedBartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
Oncomirs—MicroRNAs with a role in cancer
Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884
Calin, G. A., Dumitru, C. D., Shimizu, M., Bichi, R., Zupo, S., Noch, E., Aldler, H., Rattan, S., Keating, M., Rai, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242606799 · Cited by 5,111
Origins and Mechanisms of miRNAs and siRNAs
Carthew, R. W., & Sontheimer, E. J. (2009) · Cell · doi:10.1016/j.cell.2009.01.035 · Cited by 5,018
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
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MicroRNA genes are transcribed by RNA polymerase II
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“IL-1-receptor-associated kinase 1 and TNFreceptor-associated factor 6 are the direct targets of miR-146 and are directly involved in inflammatory responses [76].”
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Cited by
Trials and Tribulations of MicroRNA Therapeutics
Seyhan, A. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031469 · Cited by 381
Breast cancer: miRNAs monitoring chemoresistance and systemic therapy
Singh, S., Saini, H., Sharma, A., Gupta, S., Huddar, V. G., & Tripathi, R. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1155254 · Cited by 25
Multifunctional elastin-like polypeptide nanocarriers for efficient miRNA delivery in cancer therapy
Hong, J., Sim, D., Lee, B.-H., Sarangthem, V., & Park, R.-W. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02559-5 · Cited by 22
Metadata
- Authors
- Menon, A., Abd-Aziz, N., Khalid, K., Poh, C. L., & Naidu, R.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2022-09-29
- Volume
- 23
- Issue
- 19
- Pages
- 11502
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W4297977882
- Cited by
- 357
- References
- 203
- FWCI
- 24.69
- Type
- journal article
- Language
- en
- Open access
- gold
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- Menon, A., Abd-Aziz, N., Khalid, K., Poh, C. L., & Naidu, R. (2022). miRNA: A Promising Therapeutic Target in Cancer. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms231911502
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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