The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.
Zinc: From Biological Functions to Therapeutic Potential
Open accessAbstract
The trace element zinc (Zn) displays a wide range of biological functions. Zn ions control intercellular communication and intracellular events that maintain normal physiological processes. These effects are achieved through the modulation of several Zn-dependent proteins, including transcription factors and enzymes of key cell signaling pathways, namely those involved in proliferation, apoptosis, and antioxidant defenses. Efficient homeostatic systems carefully regulate intracellular Zn concentrations. However, perturbed Zn homeostasis has been implicated in the pathogenesis of several chronic human diseases, such as cancer, diabetes, depression, Wilson’s disease, Alzheimer’s disease, and other age-related diseases. This review focuses on Zn’s roles in cell proliferation, survival/death, and DNA repair mechanisms, outlines some biological Zn targets, and addresses the therapeutic potential of Zn supplementation in some human diseases.
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Cites
The NF- B Family of Transcription Factors and Its Regulation
Oeckinghaus, A., & Ghosh, S. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000034 · Cited by 2,842
ERK/MAPK signalling pathway and tumorigenesis (Review)
Guo, Y., Pan, W., Liu, S., Shen, Z., Xu, Y., & Hu, L. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.8454 · Cited by 1,475
Zinc and human health: an update
Chasapis, C. T., Loutsidou, A. C., Spiliopoulou, C. A., & Stefanidou, M. E. (2012) · Archives of Toxicology · doi:10.1007/s00204-011-0775-1 · Cited by 1,053
The Role of Zinc in Growth and Cell Proliferation
MacDonald, R. S. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.5.1500s · Cited by 954
Importance of Zinc in the Central Nervous System: The Zinc-Containing Neuron
Frederickson, C. J., Suh, S. W., Silva, D., Frederickson, C. J., & Thompson, R. B. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.5.1471s · Cited by 866
Zinc biochemistry: From a single zinc enzyme to a key element of life
Maret, W. (2013) · Advances in Nutrition · doi:10.3945/an.112.003038 · Cited by 818
Zinc and its role in immunity and inflammation
Bonaventura, P., Benedetti, G., Albarède, F., & Miossec, P. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.11.008 · Cited by 798
The Role of Zinc in Antiviral Immunity
Read, S. A., Obeid, S., Ahlenstiel, C., & Ahlenstiel, G. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz013 · Cited by 749
Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling
Jarosz, M., Olbert, M., Wyszogrodzka, G., Młyniec, K., & Librowski, T. (2017) · Inflammopharmacology · doi:10.1007/s10787-017-0309-4 · Cited by 733
Cohen, G. M., Sun, X. M., Snowden, R. T., Dinsdale, D., & Skilleter, D. N. (1992) · Biochemical Journal · doi:10.1042/bj2860331 · Cited by 672
Metadata
- Authors
- Costa, M. I., Sarmento-Ribeiro, A. B., & Gonçalves, A. C.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2023-03-02
- Volume
- 24
- Issue
- 5
- Pages
- 4822
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W4322770763
- Cited by
- 253
- References
- 134
- FWCI
- 36.39
- Type
- journal article
- Language
- en
- Open access
- gold
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