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Cited by 672

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation

Open access
Cohen, G M, Sun, X M, Snowden, R T, Dinsdale, D, Skilleter, D N·1992·Biochemical Journal
DOI 10.1042/bj2860331
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Abstract

Apoptosis, a major form of cell death, is characterized by chromatin condensation, a reduction in cell volume and endonuclease cleavage of DNA into oligonucleosomal length fragments. The detection of these fragments by gel electrophoresis, as a DNA ladder, is currently used as the major biochemical index of apoptosis. Here we report that key morphological changes of apoptosis can be dissociated experimentally from the DNA fragmentation produced by endonuclease activity. Internucleosomal cleavage of DNA is thus likely to be a later event in the apoptotic process.

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Crossref · 10.1042/bj2860331

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Metadata

Authors
Cohen, G. M., Sun, X. M., Snowden, R. T., Dinsdale, D., & Skilleter, D. N.
Venue
Biochemical Journal
Publisher
Portland Press Ltd.
Published
1992-09-01
Volume
286
Issue
2
Pages
331-334
ISSN
  • 0264-6021 (ISSN-L)
  • 1470-8728
DOI
10.1042/bj2860331
OpenAlex
W1915857360
Cited by
672
References
2
FWCI
16.03
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. https://app.cochat.ai/papers/10.1042/bj2860331
The paper
Cohen, G. M., Sun, X. M., Snowden, R. T., Dinsdale, D., & Skilleter, D. N. (1992). Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. Biochemical Journal. https://doi.org/10.1042/bj2860331

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.