Oat (Avena sativa L.) Sprouts Restore Skin Barrier Function by Modulating the Expression of the Epidermal Differentiation Complex in Models of Skin Irritation
Open accessAbstract
Oats (Avena sativa L.) are used as therapeutic plants, particularly in dermatology. Despite numerous studies on their skin moisturization, anti-inflammation, and antioxidation effects, the precise molecular mechanisms of these effects are only partially understood. In this study, the efficacy of oat sprouts in the treatment of allergic contact dermatitis (ACD) was investigated, and their specific phytoconstituents and exact mechanisms of action were identified. In the in vivo ACD model, by stimulating the mitogen-activated protein kinase signaling pathway, oat sprouts increased the expression levels of proteins associated with skin barrier formation, which are produced during the differentiation of keratinocytes. In addition, in a lipopolysaccharide-induced skin irritation model using HaCaT, steroidal saponins (avenacoside B and 26-deglucoavenacoside B) and a flavonoid (isovitexin-2-o-arabinoside) of oat sprouts regulated the genetic expression of the same proteins located on the adjacent locus of human chromosomes known as the epidermal differentiation complex (EDC). Furthermore, oat sprouts showed immunomodulatory functions. These findings suggest the potential for expanding the use of oat sprouts as a treatment option for various diseases characterized by skin barrier disruption.
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Oat (Avena sativa) and chamomile (Chamomilla recutita) extracts have anti-inflammatory, anti-oxidant, and skin barrier-stabilizing properties.
“These include plant extracts such as oat (Avena sativa) and chamomile (Chamomilla recutita) extracts, which have anti-inflammatory, anti-oxidant, and skin barrier-stabilizing properties [28,29].”
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Cites
MAPK signal pathways in the regulation of cell proliferation in mammalian cells
ZHANG, W., & LIU, H. T. (2002) · Cell Research · doi:10.1038/sj.cr.7290105 · Cited by 2,845 · see citing works
Filaggrin in the frontline: role in skin barrier function and disease
Sandilands, A., Sutherland, C. D., Irvine, A. D., & McLean, W. H. I. (2009) · Journal of Cell Science · doi:10.1242/jcs.033969 · Cited by 885 · see citing works
Bricks and mortar of the epidermal barrier
Nemes, Z., & Steinert, P. M. (1999) · Experimental & Molecular Medicine · doi:10.1038/emm.1999.2 · Cited by 567 · see citing works
Cholesterol-lowering effects of oat β-glucan: a meta-analysis of randomized controlled trials
Whitehead, A., Beck, E. J., Tosh, S. M., & Wolever, T. M. S. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.086108 · Cited by 386 · see citing works
Effector and regulatory mechanisms in allergic contact dermatitis
Vocanson, M., Hennino, A., Rozières, A., Poyet, G., & Nicolas, J. (2009) · Allergy · doi:10.1111/j.1398-9995.2009.02082.x · Cited by 364 · see citing works
Kypriotou, M., Huber, M., & Hohl, D. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01472.x · Cited by 334 · see citing works
Avena sativa (Oat), A Potential Neutraceutical and Therapeutic Agent: An Overview
Singh, R., De, S., & Belkheir, A. K. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.526725 · Cited by 272 · see citing works
Mast Cell-Associated TNF Promotes Dendritic Cell Migration
Suto, H., Nakae, S., Kakurai, M., Sedgwick, J. D., Tsai, M. M., & Galli, S. J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4102 · Cited by 264 · see citing works
Avenanthramides, polyphenols from oats, exhibit anti-inflammatory and anti-itch activity
Sur, R., Nigam, A., Grote, D., Liebel, F., & Southall, M. D. (2008) · Archives of Dermatological Research · doi:10.1007/s00403-008-0858-x · Cited by 240 · see citing works
The persistence of atopic dermatitis and filaggrin (FLG) mutations in a US longitudinal cohort
Margolis, D. J., Apter, A. J., Gupta, J., Hoffstad, O., Papadopoulos, M., Campbell, L., Sandilands, A., McLean, W. H. I., Rebbeck, T. R., & Mitra, N. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.07.008 · Cited by 217 · see citing works
Kamata, Y., Taniguchi, A., Yamamoto, M., Nomura, J., Ishihara, K., Takahara, H., Hibino, T., & Takeda, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807908200 · Cited by 170 · see citing works
The multiple factors affecting the association between atopic dermatitis and contact sensitization
Thyssen, J. P., McFadden, J. P., & Kimber, I. (2013) · Allergy · doi:10.1111/all.12358 · Cited by 161 · see citing works
Hoffjan, S., & Stemmler, S. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.07999.x · Cited by 135 · see citing works
SASPase regulates stratum corneum hydration through profilaggrin‐to‐filaggrin processing
Matsui, T., Miyamoto, K., Kubo, A., Kawasaki, H., Ebihara, T., Hata, K., Tanahashi, S., Ichinose, S., Imoto, I., Inazawa, J., et al. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100140 · Cited by 123 · see citing works
Edible Plant Sprouts: Health Benefits, Trends, and Opportunities for Novel Exploration
Aloo, S. O., Ofosu, F. K., Kilonzi, S. M., Shabbir, U., & Oh, D. H. (2021) · Nutrients · doi:10.3390/nu13082882 · Cited by 118 · see citing works
Abnormal epidermal barrier in the pathogenesis of contact dermatitis
Proksch, E., & Brasch, J. (2012) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2011.08.019 · Cited by 95 · see citing works
In vitro antioxidant capacity and anti-inflammatory activity of seven common oats
Chu, Y., Wise, M. L., Gulvady, A. A., Chang, T., Kendra, D. F., van Klinken, B. J., Shi, Y., & O’Shea, M. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.01.104 · Cited by 91 · see citing works
Kim, J. H., Bae, H. C., Ko, N. Y., Lee, S. H., Jeong, S. H., Lee, H., Ryu, W.-I., Kye, Y. C., & Son, S. W. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.04.026 · Cited by 75 · see citing works
Loricrin: Past, Present, and Future
Ishitsuka, Y., & Roop, D. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072271 · Cited by 71 · see citing works
(2015) · PubMed · Cited by 57 · see citing works
Cytokine regulation of the epidermal barrier
Gutowska‐Owsiak, D., & Ogg, G. S. (2012) · Clinical & Experimental Allergy · doi:10.1111/cea.12023 · Cited by 52 · see citing works
Roles of Mast Cells in Cutaneous Diseases
Numata, T., Harada, K., & Nakae, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.923495 · Cited by 52 · see citing works
MAPK pathway involved in epidermal terminal differentiation of normal human epidermal keratinocytes
Meng, X., Qiu, L., Song, H., & Dang, N. (2018) · Open Medicine · doi:10.1515/med-2018-0029 · Cited by 48 · see citing works
Hampton, A., Hish, G. A., Aslam, M. N., Rothman, E. D., Bergin, I. L., Patterson, K. A., Naik, M., Paruchuri, T., Varani, J., & Rush, H. G. (2012) · Europe PMC (PubMed Central) · Cited by 41 · see citing works
Ariès, M.-F., Vaissière, C., Pinelli, É., Pipy, B., & Charvéron, M. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.601 · Cited by 35 · see citing works
Cosmeceuticals based on Rhealba® Oat plantlet extract for the treatment of acne vulgaris
Fabbrocini, G., & Aroman, M. S. (2014) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12791 · Cited by 28 · see citing works
Colloidal Oatmeal (Avena Sativa) Improves Skin Barrier Through Multi-Therapy Activity.
Ilnytska, O., Kaur, S., Chon, S., Reynertson, K. A., Nebus, J. A., Garay, M., Mahmood, K., & Southall, M. D. (2016) · PubMed · Cited by 22 · see citing works
Woo, S.-Y., Yang, J. Y., Lee, H., Ahn, H. J., Lee, Y. B., Hee, S., Kim, J. Y., & Seo, W. D. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.131429 · Cited by 10 · see citing works
Self-citationPark, J., Lee, J., Kim, S. H., Oh, J., Roh, W. S., Kim, S. M., Park, C. O., Lee, M., & Kim, T. (2021) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2021.10.001 · Cited by 5 · see citing works
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Cheng, F., Feng, J., Cao, Z., Qu, D., & Li, H. (2024) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16710 · Cited by 17 · see citing works
Xiong, B., Li, Y., Yao, J., Wang, J., Han, L., Qingqing, M., Deng, T., Liao, L., Deng, L., Sun, G., et al. (2025) · BMC Plant Biology · doi:10.1186/s12870-025-06414-z · Cited by 11 · see citing works
Chang, T.-M., Wu, C.-C., Huang, H.-C., Lu, J.-Y., Chuang, C.-H., Kao, P.-L., Tang, W.-H., Liu, L. T.-C., Qiu, W.-Y., Percec, I., et al. (2025) · Cosmetics · doi:10.3390/cosmetics12050186 · Cited by 7 · see citing works
Infectious factors in atopic dermatitis, pharmaceutical possibilities (systematic literature review)
Konyshko, N. A., Konyshko, G. S., Matveeva, D. A., Volynets, L. I., & Киреева, А. А. (2025) · Russian Journal of Clinical Dermatology and Venereology · doi:10.17116/klinderma2025240117 · Cited by 4 · see citing works
Dual-action fermented oats (Avena sativa L.): Anti-inflammatory and skin barrier restoration
Liu, M., Wang, L., Li, Y., Zhang, P., Wang, C., Wu, Y., Chen, Y., Huang, H., & Li, X. (2025) · Journal of Dermatologic Science and Cosmetic Technology · doi:10.1016/j.jdsct.2025.100103 · Cited by 3 · see citing works
Lee, H. J., Kim, K. J., Park, S.-Y., Choi, K., Pyee, J., Yoo, S., & Kim, J. Y. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104833 · Cited by 3 · see citing works
Gaba, A., & Bennett, R. (2024) · JMIR Formative Research · doi:10.2196/63281 · Cited by 3 · see citing works
Xerosis: from pathogenesis to solving practical problems
Torshina, I. E. (2024) · Vestnik dermatologii i venerologii · doi:10.25208/vdv16749 · Cited by 2 · see citing works
Crnčević, M. Š., Durdov, T., Rušić, D., Ramić, L., Ćosić, A., & Bukić, J. (2025) · Cosmetics · doi:10.3390/cosmetics12060269
Saraswat, A., De, A., Matang, N., Reddy, P., Thakor, P., Shah, R., & Rayasam, S. (2026) · Cureus · doi:10.7759/cureus.102885
Cayce, K. A., Jacobs, K. M., & Boda, S. (2026) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.70746
Sprout Extracts in Skin Care and Hair Growth: Evidence and Future Opportunities
Paździora, W., Paśko, P., & Galanty, A. (2026) · Applied Sciences · doi:10.3390/app16094520
Oat β‐Glucan Improves Skin Barrier Repair by Regulating EGFR Signaling Pathway
Jiang, X., Wu, S., Hong, S., Ren, H., Dong, Y., & Liu, Y. (2026) · Dermatologic Therapy · doi:10.1155/dth/9852011
Saran, V., & Syamala, G. (2026) · Next research. · doi:10.1016/j.nexres.2026.102311
Chrysikopoulou, V., Kyprou, K., & Τσούπρας, Α. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27500-5.00015-0
Growth, evolution, research and development trends, and future perspectives
Lafara, M.-P., Adamantidi, T., & Τσούπρας, Α. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27500-5.00025-3
Telogen effluvium: From causes of hair loss to proper care
Khadeejeh, M. B. A., Руслановна, С. Л., & Korsunskaya, I. M. (2026) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2026-388
Formulation and Evaluation of Herbal Scrub of Papaya and Oatmeal
Dongre, D., & Tathe, P. (2026) · Asian Journal of Pharmacy and Technology · doi:10.52711/2231-5713.2026.00049
- Authors
- Kim, H.-S., Hwang, H.-J., Seo, W.-D., & Do, S.-H.
- Affiliations
- Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul 05029, Republic of Korea
- Konkuk University (KR)
- Rural Development Administration (KR)
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2023-12-08
- Volume
- 24
- Issue
- 24
- Pages
- 17274
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC10743458
- OpenAlex
- W4389570700
- Cited by
- 18
- References
- 30
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 4
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Rural Development Administration (RDA) (RS-2019-RD007807)
- Topics
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- Avena sativa, epidermal differentiation complex, skin barrier function, allergic contact dermatitis, skin irritation, keratinocyte differentiation, MAPK signaling, steroidal saponins, flavonoids, immunomodulation, phytochemical constituents, HaCaT keratinocytes, lipopolysaccharide
- MeSH terms
- Anti-Inflammatory Agents, Edible Grain, Humans, Inflammation, Plant Extracts, Skin, Avena
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