Cited by 18Contact Dermatitis and AllergiesDermatology and Skin DiseasesSkin Protection and Aging

Oat (Avena sativa L.) Sprouts Restore Skin Barrier Function by Modulating the Expression of the Epidermal Differentiation Complex in Models of Skin Irritation

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Kim, Hyo-Sung, Hwang, Hyun-Jeong, Seo, Woo-Duck, Do, Sun-Hee·2023·International Journal of Molecular Sciences

Abstract

Oats (Avena sativa L.) are used as therapeutic plants, particularly in dermatology. Despite numerous studies on their skin moisturization, anti-inflammation, and antioxidation effects, the precise molecular mechanisms of these effects are only partially understood. In this study, the efficacy of oat sprouts in the treatment of allergic contact dermatitis (ACD) was investigated, and their specific phytoconstituents and exact mechanisms of action were identified. In the in vivo ACD model, by stimulating the mitogen-activated protein kinase signaling pathway, oat sprouts increased the expression levels of proteins associated with skin barrier formation, which are produced during the differentiation of keratinocytes. In addition, in a lipopolysaccharide-induced skin irritation model using HaCaT, steroidal saponins (avenacoside B and 26-deglucoavenacoside B) and a flavonoid (isovitexin-2-o-arabinoside) of oat sprouts regulated the genetic expression of the same proteins located on the adjacent locus of human chromosomes known as the epidermal differentiation complex (EDC). Furthermore, oat sprouts showed immunomodulatory functions. These findings suggest the potential for expanding the use of oat sprouts as a treatment option for various diseases characterized by skin barrier disruption.

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Authors
Kim, H.-S., Hwang, H.-J., Seo, W.-D., & Do, S.-H.
Affiliations
  • Department of Veterinary Clinical Pathology, College of Veterinary Medicine, Konkuk University, Gwangjin-gu, Seoul 05029, Republic of Korea
  • Konkuk University (KR)
  • Rural Development Administration (KR)
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2023-12-08
Volume
24
Issue
24
Pages
17274
ISSN
1422-0067 (ISSN-L)
OpenAlex
W4389570700
Cited by
18
References
30
Citations by year
2026: 9 · 2025: 5 · 2024: 4
FWCI
4.96
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Rural Development Administration (RDA) (RS-2019-RD007807)
Topics
  • Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
Avena sativa, epidermal differentiation complex, skin barrier function, allergic contact dermatitis, skin irritation, keratinocyte differentiation, MAPK signaling, steroidal saponins, flavonoids, immunomodulation, phytochemical constituents, HaCaT keratinocytes, lipopolysaccharide
MeSH terms
Anti-Inflammatory Agents, Edible Grain, Humans, Inflammation, Plant Extracts, Skin, Avena

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