Thymic stromal lymphopoietin downregulates filaggrin expression by signal transducer and activator of transcription 3 (STAT3) and extracellular signal-regulated kinase (ERK) phosphorylation in keratinocytes
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Inhibition of FLG expression by keratinocyte-derived cytokines including TNF-α, TSLP, IL-1β, IL-33, and IL-25 has been documented.
“Inhibition of FLG expression by keratinocyte-derived cytokines including TNF-α (37), thymic stromal lymphopoietin (TSLP) (38), IL-1β (39), IL-33 (40), and IL-25 (41) has been documented.”
From Particulate matter causes skin barrier dysfunction. (2021) · cites this paper as [38]
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- Authors
- Kim, J. H., Bae, H. C., Ko, N. Y., Lee, S. H., Jeong, S. H., Lee, H., Ryu, W.-I., Kye, Y. C., & Son, S. W.
- Affiliations
- Korea University (KR)
- Corresponding author
- Son, Sang Wook
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 136
- Issue
- 1
- Pages
- 205-208.e9
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2140451759
- Cited by
- 75
- References
- 10
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 5 · 2023: 4 · 2022: 10 · 2021: 10 · 2020: 4 · 2019: 3 · 2018: 7 · 2017: 5 · 2016: 12
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- thymic stromal lymphopoietin, filaggrin, STAT3, ERK1/2 phosphorylation, keratinocytes, atopic dermatitis, skin barrier dysfunction, skin inflammation, Th2 cytokines, IL-4, IL-13, IgE
- MeSH terms
- Filaggrin Proteins, Thymic Stromal Lymphopoietin, Cells, Cultured, Dermatitis, Atopic, Humans, Intermediate Filament Proteins, Phosphorylation, Skin, Signal Transduction, Down-Regulation, Keratinocytes, Cytokines, Receptors, Cytokine, Receptors, Interleukin-7, Extracellular Signal-Regulated MAP Kinases, STAT3 Transcription Factor
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