The DOI matches its Crossref record; 162 of the 162 references it cites were found in a registry or an index.
The Role of Short Chain Fatty Acids in Inflammation and Body Health
Open accessAbstract
Short chain fatty acids (SCFAs), mainly including acetate, propionate and butyrate, are produced by intestinal bacteria during the fermentation of partially digested and indigestible polysaccharides. SCFAs play an important role in regulating intestinal energy metabolism and maintaining the homeostasis of the intestinal environment and also play an important regulatory role in organs and tissues outside the gut. In recent years, many studies have shown that SCFAs can regulate inflammation and affect host health, and two main signaling mechanisms have also been identified: the activation of G-protein coupled receptors (GPCRs) and inhibition of histone deacetylase (HDAC). In addition, a growing body of evidence highlights the importance of every SCFA in influencing health maintenance and disease development. In this review, we summarized the recent advances concerning the biological properties of SCFAs and their signaling pathways in inflammation and body health. Hopefully, it can provide a systematic theoretical basis for the nutritional prevention and treatment of human diseases.
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Cited by
Wang, W.-L., Shih, Y.-T., Wei, S.-Y., & Chiu, J.-J. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01177-z · Cited by 50
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Wu, Y., Zhou, Y., Fan, Q., Gao, Y., Fang, S., Sun, Y., & Gu, S. (2026) · European Journal of Nutrition · doi:10.1007/s00394-026-03953-5
Metadata
- Authors
- Du, Y., He, C., An, Y., Huang, Y., Zhang, H., Fu, W., Wang, M., Shan, Z., Xie, J., Yang, Y., & Zhao, B.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2024-07-05
- Volume
- 25
- Issue
- 13
- Pages
- 7379
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W4400411818
- Cited by
- 384
- References
- 162
- FWCI
- 44.62
- Type
- journal article
- Language
- en
- Open access
- gold
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- Du, Y., He, C., An, Y., Huang, Y., Zhang, H., Fu, W., Wang, M., Shan, Z., Xie, J., Yang, Y., & Zhao, B. (2024). The Role of Short Chain Fatty Acids in Inflammation and Body Health. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms25137379
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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