Cited by 24Suicide and Self-Harm StudiesLipoproteins and Cardiovascular HealthTreatment of Major Depression

The relationships between abnormal serum lipid levels, depression, and suicidal ideation according to sex

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Lee, Kounseok, Kim, Sunhae, Jo, Jung Ki·2022·Journal of Clinical Medicine

Abstract

(1) Background: Serum lipid levels affect not only nutritional status but also emotional state. The purpose of this study was to examine the effects of various socio-demographic characteristics, abnormal cholesterol levels, and BMI indicators on depressive symptoms and suicidal ideation in the Korean population. (2) Methods: A total of 23,692 people were surveyed using data from the Korea National Health and Nutrition Examination Survey (KNHNES) 2014, 2016, and 2018. Data from 11,653 patients were analyzed. Age, sex, chronic disease, smoking, alcohol consumption, total cholesterol (HDL, triglycerides), BMI, depression, and suicidal ideation were measured. (3) Results: According to sex, low HDL, high triglycerides, and suicidal ideation were significant, along with low education level, smoking, binge drinking, and high BMI. High triglyceride level was shown to significantly increase the risk of depression in males (OR = 1.535, 95% CI = 1.098-2.147). Factors affecting suicidal ideation in males were age, binge drinking, and depression, while blood lipid factors were not significant. (4) Conclusions: Of the types of serum lipid factors affecting depression and suicidal ideation, high triglycerides were found to be a risk factor for depression in men. Serum lipids can be used as biomarkers to reflect depressive symptoms in men depending on cholesterol level.

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  1. Cadeddu, 1995, Associazione tra livelli di colesterolo e depressione nell’anziano, Minerva Med., 86, 251
  2. Hong, 1999, Relationship between Serum Lipids and Psychiatric Symptoms, Korean J. Psychopharmacol., 10, 120

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Authors
Lee, K., Kim, S., & Jo, J. K.
Affiliations
Hanyang University Seoul Hospital (KR)
Corresponding author
Jo, Jung Ki
Venue
Journal of Clinical Medicine
Publisher
MDPI AG
Published
2022-04-11
Volume
11
Issue
8
Pages
2119
ISSN
2077-0383 (ISSN-L)
OpenAlex
W4223487536
Cited by
24
References
47
Citations by year
2026: 3 · 2025: 8 · 2024: 10 · 2023: 2 · 2022: 1
FWCI
4.80
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Hanyang University (HY-2019)
  • Ministry of Trade, Industry and Energy (Industrial Strategic Technology Development Program (20016364))
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
serum lipids, depression, suicidal ideation, sex differences, triglycerides, HDL cholesterol, body mass index, binge drinking, smoking, biomarkers, Korean adults

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