Association between total serum cholesterol and suicide attempts in subjects with major depressive disorder: exploring the role of clinical and biochemical confounding factors
Abstract
Objectives We tested whether serum total cholesterol levels might be associated with recent suicide attempts in subjects with major depressive disorder, after controlling for relevant individual characteristics.Design and methods We conducted a comparative cross-sectional study including consecutive inpatients with major depressive disorder. We differentiated subjects admitted for a recent serious (violent or non-violent) suicide attempt and those without such recent history. Total cholesterol was measured from fasting blood tests.Results At univariate analyses, suicide attempters had levels of total cholesterol (174.0±45.7mg/dL) lower than non-attempters (193.9±42.6mg/dL) (p=0.004). This was confirmed among both violent (174.1±46.2mg/dL) and non-violent (173.8±46.1mg/dL) suicide attempters (p=0.035 and 0.016, respectively). However, logistic regression analyses, sequentially including demographic, clinical (comorbid alcohol and personality disorders), and biochemical factors, did not show any association between serum cholesterol and recent suicide attempts (p=0.172). Similar findings were observed in multinomial logistic regression analyses, for both violent (p=0.512) and non-violent (p=0.157) suicide attempts.Conclusions Our findings do not support the hypothesis that serum cholesterol and suicide attempts are associated among subjects with major depressive disorder. The identification of valid and accessible biological markers of suicidal behaviors still represents a challenge for future research.
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The association with suicidal behavior or attempts in patients with mental disorders is not clear.
“Another research finding was that the level of lipids is not related to depressive symptoms in people [19], and also the association with suicidal behavior or attempts in patients with mental disorders is not clear [20,21].”
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- Authors
- Bartoli, F., Crocamo, C., Dakanalis, A., Riboldi, I., Miotto, A., Brosio, E., Clerici, M., & Carrà, G.
- Affiliations
- University of Milano-Bicocca (IT)
- University College London (GB)
- Corresponding author
- Bartoli, Francesco
- ORCID
- Venue
- Clinical Biochemistry
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 50
- Issue
- 6
- Pages
- 274-278
- ISSN
- 0009-9120 (ISSN-L)
- OpenAlex
- W2559885981
- Cited by
- 48
- References
- 46
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 4 · 2022: 8 · 2021: 3 · 2020: 9 · 2019: 6 · 2018: 6 · 2017: 3
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- total cholesterol, suicide attempts, major depressive disorder, violent suicide attempts, confounding factors, personality disorders
- MeSH terms
- Cholesterol, Cross-Sectional Studies, Depressive Disorder, Major, Major Depressive Disorder, Female, Hospitalization, Humans, Male, Middle Aged, Risk Factors, Suicide, Attempted, Comorbidity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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