Subretinal Injection Techniques for Retinal Disease: A Review

Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65 -mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial

Russell, S., Bennett, J., Wellman, J. A., Chung, D. C., Yu, Z.-F., Tillman, A., Wittes, J., Pappas, J., Elci, O., McCague, S., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31868-8 · Cited by 1,952

Effect of gene therapy on visual function in Leber’s congenital amaurosis

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Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt's macular dystrophy: follow-up of two open-label phase 1/2 studies

Schwartz, S. D., Regillo, C. D., Lam, B. L., Eliott, D., Rosenfeld, P. J., Gregori, N. Z., Hubschman, J.-P., Davis, J. L., Heilwell, G., Spirn, M., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61376-3 · Cited by 1,327

Gene therapy restores vision in a canine model of childhood blindness

Acland, G. M., Aguirre, G. D., Ray, J., Zhang, Q., Aleman, T. S., Cideciyan, A. V., Pearce-Kelling, S. E., Anand, V., Zeng, Y., Maguire, A. M., et al. (2001) · Nature Genetics · doi:10.1038/ng0501-92 · Cited by 1,202 · cited 1×

Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial

Maguire, A. M., High, K. A., Auricchio, A., Wright, J. F., Pierce, E. A., Testa, F., Mingozzi, F., Bennicelli, J. L., Ying, G.-S., Rossi, S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61836-5 · Cited by 865

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial

MacLaren, R. E., Groppe, M., Barnard, A. R., Cottriall, C. L., Tolmachova, T., Seymour, L., Clark, K. R., During, M. J., Cremers, F. P. M., Black, G. C. M., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62117-0 · Cited by 796

Pharmacokinetic aspects of retinal drug delivery

del Amo, E. M., Rimpelä, A.-K., Heikkinen, E., Kari, O. K., Ramsay, E., Lajunen, T., Schmitt, M., Pelkonen, L., Bhattacharya, M., Richardson, D., et al. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.12.001 · Cited by 693

The molecular basis of human retinal and vitreoretinal diseases

Berger, W., Kloeckener‐Gruissem, B., & Neidhardt, J. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.03.004 · Cited by 609

Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector

Miyoshi, H., Takahashi, M., Gage, F. H., & Verma, I. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10319 · Cited by 497

Drug Delivery to the Posterior Segment of the Eye: Biopharmaceutic and Pharmacokinetic Considerations

Varela‐Fernández, R., Díaz-Tomé, V., Luaces-Rodríguez, A., Conde-Penedo, A., García‐Otero, X., Álvarez, A. L., Fernández‐Ferreiro, A., & Otero-Espinar, F. J. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12030269 · Cited by 374

Overview of Recent Advances in Nano-Based Ocular Drug Delivery

Liu, L.-C., Chen, Y., & Lu, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015352 · Cited by 152

Near-infrared spatiotemporal color vision in humans enabled by upconversion contact lenses

Ma, Y., Chen, Y., Wang, S., Chen, Z., Zhang, Y., Huang, L. F., Zhang, X., Yin, F., Wang, Y., Yang, M., et al. (2025) · Cell · doi:10.1016/j.cell.2025.04.019 · Cited by 55

Next generation therapeutics for retinal neurodegenerative diseases

Appell, M. B., Pejavar, J., Pasupathy, A., Rompicharla, S. V. K., Abbasi, S., Malmberg, K., Kolodziejski, P., & Ensign, L. M. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.01.063 · Cited by 33

The Role of Subretinal Injection in Ophthalmic Surgery: Therapeutic Agent Delivery and Other Indications

Tripepi, D., Jalil, A., Ally, N., Buzzi, M., Moussa, G., Rothschild, P.-R., Rossi, T., Ferrara, M., & Romano, M. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310535 · Cited by 31

Biomechanical considerations for optimising subretinal injections

L’Abbate, D., Prescott, K., Geraghty, B., Kearns, V., & STEEL, D. H. (2024) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2024.05.004 · Cited by 26

Beyond the injection: delivery systems reshaping retinal disease management

Rowe, L. W., Akotoye, C., Harris, A., & Ciulla, T. A. (2025) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2025.2496424 · Cited by 22

Can Gene Therapy Transform the Treatment Landscape of Posterior Segment Eye Diseases? A Comprehensive Review of Recent Advancements

Chen, K.-S., Chan, H.-C., & Chan, C.-M. (2025) · Drugs · doi:10.1007/s40265-025-02237-2 · Cited by 22

AAV2 and AAV9 tropism and transgene expression in the mouse eye and major tissues after intravitreal and subretinal delivery

Koponen, S., Kokki, E., Tamminen, T., & Ylä-Herttuala, S. (2023) · Frontiers in Drug Delivery · doi:10.3389/fddev.2023.1148795 · Cited by 21

Seeing the Future: A Review of Ocular Therapy

Whalen, M., Akula, M., McNamee, S. M., DeAngelis, M. M., & Haider, N. B. (2024) · Bioengineering · doi:10.3390/bioengineering11020179 · Cited by 21

Gene Therapy in Hereditary Retinal Dystrophies: The Usefulness of Diagnostic Tools in Candidate Patient Selections

Malvasi, M., Casillo, L., Avogaro, F., Abbouda, A., & Vingolo, E. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813756 · Cited by 21

Novel Approaches in the Drug Development and Delivery Systems for Age-Related Macular Degeneration

Paliwal, H., Prajapati, B. G., Srichana, T., Singh, S. K., & Patel, R. J. (2023) · Life · doi:10.3390/life13020568 · Cited by 21

Therapeutic Extracellular Vesicles from Tonsil-Derived Mesenchymal Stem Cells for the Treatment of Retinal Degenerative Disease

Choi, S. W., Seo, S., Hong, H. K., Yoon, S. J., Kim, M., Moon, S., Lee, J. Y., Lim, J., Lee, J. B., & Woo, S. J. (2023) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-023-00555-8 · Cited by 18

Preclinical evaluation of KH631, a novel rAAV8 gene therapy product for neovascular age-related macular degeneration

Xiao, K., Jiang, H., Li, Q., Luo, S., Qin, Y., Li, J., Xie, Q., & Zheng, Q. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.09.019 · Cited by 17

An open-label phase II study assessing the safety of bilateral, sequential administration of retinal gene therapy in participants with choroideremia: the GEMINI study

MacLaren, R. E., Audo, I., Fischer, M. D., Huckfeldt, R. M., Lam, B. L., Pennesi, M. E., Sisk, R., Gow, J. A., Li, J., Zhu, K., et al. (2024) · Human Gene Therapy · doi:10.1089/hum.2024.017 · Cited by 15

A Comparative Analysis of Models for AAV-Mediated Gene Therapy for Inherited Retinal Diseases

Alsalloum, A., Gornostal, E. A., Mingaleva, N., Pavlov, R. E., Kuznetsova, E., Antonova, E., Nadzhafova, A., Колотова, Д. Е., Кадышев, В. В., Mityaeva, O. N., et al. (2024) · Cells · doi:10.3390/cells13201706 · Cited by 17

Real-Time Deformation-Aware Control for Autonomous Robotic Subretinal Injection Under iOCT Guidance

Arikan, D., Zhang, P., Sommersperger, M., Dehghani, S., Esfandiari, M., Taylor, R. H., Nasseri, M. A., Gehlbach, P. L., Navab, N., & Iordachita, I. I. (2025) · Proceedings - IEEE International Conference on Robotics and Automation/Proceedings · doi:10.1109/icra55743.2025.11128595 · Cited by 14

Pharmacotherapy and Nutritional Supplements for Neovascular Eye Diseases

Rusciano, D., & Bagnoli, P. (2023) · Medicina · doi:10.3390/medicina59071334 · Cited by 14

High‐Efficiency Ocular Delivery of Brain‐Derived Neurotrophic Factor and Oligomycin for Neuroprotection in Glaucoma

Cao, Y., Yin, X., Wu, L., Huang, D., Wang, Z., Wu, F., Jiang, J., Chen, G., & Wang, Q. (2025) · Advanced Materials · doi:10.1002/adma.202500623 · Cited by 12

Recent advances and future challenges in nanosystems for ocular drug delivery

Shahror, R. A., & Fouda, A. Y. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103738 · Cited by 12

Advances and Challenges in Gene Therapy for Inherited Retinal Dystrophies: A Comprehensive Review

Jain, R., & Daigavane, S. V. (2024) · Cureus · doi:10.7759/cureus.69895 · Cited by 14

Head-mounted surgical robots are an enabling technology for subretinal injections

Posselli, N. R., Hwang, E. S., Olson, Z. J., Nagiel, A., Bernstein, P. S., & Abbott, J. J. (2025) · Science Robotics · doi:10.1126/scirobotics.adp7700 · Cited by 12

Chronic In Vivo CRISPR-Cas Genome Editing: Challenges, Long-Term Safety, and Outlook

Bao, C., Channell, C. I., Tseng, Y.-H., Bailey, J., Sbaiti, N., Demirkol, A., & Tsang, S. H. (2026) · Cells · doi:10.3390/cells15020156 · Cited by 14

New Directions for Ophthalmic OCT – Handhelds, Surgery, and Robotics

Foust, J. S., McCloud, M., Narawane, A. M., Trout, R. M., Chen, X., Dhalla, A.-H. Z., Li, J. D., Viehland, C., Draelos, M., Vajzovic, L. M., et al. (2025) · Translational Vision Science & Technology · doi:10.1167/tvst.14.1.14 · Cited by 11

In Vivo Efficacy and Safety Evaluations of Therapeutic Splicing Correction Using U1 snRNA in the Mouse Retina

Swirski, S., May, O., Ahlers, M. T., Wissinger, B., Greschner, M., Jüschke, C., & Neidhardt, J. (2023) · Cells · doi:10.3390/cells12060955 · Cited by 10

Recent developments in imaging and surgical vision technologies currently available for improving vitreoretinal surgery: a narrative review

Sadeghi, E., Mohan, S., Iannetta, D., & Chhablani, J. K. (2023) · Expert Review of Medical Devices · doi:10.1080/17434440.2023.2231841 · Cited by 10

Subretinal Gene Therapy for Treatment of Retinal and Choroidal Vascular Diseases

Khanani, A. M., Aziz, A. A., Khanani, Z. A., Khan, H., Mojumder, O., Sulahria, H., Khanani, I., Khan, H., Gahn, G. M., & Mishra, K. (2024) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2024.12.002 · Cited by 9

Co-delivery of antioxidants and siRNA-VEGF: promising treatment for age-related macular degeneration

Dias, M. F., da Cruz-Cazarim, E. L. C., Pittella, F., Baião, A., Pacheco, C., Sarmento, B. F. C. C., & Fialho, S. L. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01772-x · Cited by 9

Towards Motion Compensation in Autonomous Robotic Subretinal Injections

Arikan, D., Esfandiari, M., Zhang, P., Sommersperger, M., Dehghani, S., Taylor, R. H., Nasseri, M. A., Gehlbach, P. L., Navab, N., & Iordachita, I. I. (2025) · International Symposium on Medical Robotics · doi:10.1109/ismr67322.2025.11025990 · Cited by 9

Handheld motorized injection system with fiber-optic distance sensors and adaptive time-delay controller

Im, J., Park, S., & Song, C. O. (2023) · International Journal of Optomechatronics · doi:10.1080/15599612.2023.2299023 · Cited by 9

Three-dimensional heads-up system assisted pars plana vitrectomy and subretinal recombinant tissue plasminogen activator injection for submacular hemorrhage

Zhao, X., Zhao, Q., Wang, E., Li, N., Meng, L., Zhang, W., Wang, T., Chen, Y., & Min, H. (2023) · Eye and Vision · doi:10.1186/s40662-023-00326-5 · Cited by 8

Optical coherence tomography for noninvasive monitoring of drug delivery

Aglyamov, S. R., & Larin, K. V. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115571 · Cited by 8

Feasibility of direct vitrectomy-sparing subretinal injection for gene delivery in large animals

Stranak, Z., Ardan, T., Nemesh, Y., Toms, M., Toualbi, L., Harbottle, R., Ellederova, Z., Lytvynchuk, L., Petrovski, G., Motlik, J., et al. (2024) · Current Eye Research · doi:10.1080/02713683.2024.2343335 · Cited by 7

Preclinical safety and biodistribution of SPVN06, a novel gene- and mutation-independent gene therapy for rod-cone dystrophies

Marie, M., Churet, L., Gautron, A.-S., Farjo, R. A., Mizuyoshi, K., Stevenson, V. A., Khabou, H., Léveillard, T., Sahel, J., & Lorget, F. (2025) · Gene Therapy · doi:10.1038/s41434-025-00556-3 · Cited by 7

A soft micron accuracy robot design and clinical validation for retinal surgery

Chen, Y., Guo, X., Ye, X., Jiang, T., Chen, H., Yu, J., Yang, G., Knoll, A., Cui, D., Zhou, M., et al. (2025) · Microsystems & Nanoengineering · doi:10.1038/s41378-025-01002-5 · Cited by 7

Design and analyses of tendon-driven continuum robots for minimally invasive surgery

Varga, M., Sinčák, P. J., Merva, T., Marcinko, P., Miková, Ľ., Prada, E., Schnitzer, M., & Virgala, I. (2024) · IFAC-PapersOnLine · doi:10.1016/j.ifacol.2024.07.366 · Cited by 7

Development of a novel SupraChoroidal-to-Optic-NervE (SCONE) drug delivery system

Chiang, B., Heng, K., Jang, K., Dalal, R., Liao, Y. J., Myung, D. J., & Goldberg, J. L. (2024) · Drug Delivery · doi:10.1080/10717544.2024.2379369 · Cited by 6

dCasMINI-mediated therapy rescues photoreceptors degeneration in a mouse model of retinitis pigmentosa

Wang, Q. K., Xu, X., Chen, S., Lu, R., Li, L., Lo, C., Liu, Z., Ning, K., Li, T., Kowal, T. J., et al. (2024) · Science Advances · doi:10.1126/sciadv.adn7540 · Cited by 6

“Blindness” is not a contraindication for voretigene neparvovec-rzyl treatment: a review of 9 cases

Parameswarappa, D. C., Stephenson, K. A. J., Seamone, M. E., Qian, C. X., Muni, R. H., Kertes, P. J., Vincent, A., & Héon, E. (2025) · Canadian Journal of Ophthalmology · doi:10.1016/j.jcjo.2024.12.013 · Cited by 6

Latest trends & strategies in ocular drug delivery

Kulkarni, N. S., Josowitz, A. D., James, R., Liu, Y., Rayaprolu, B. M., Sagdullaev, B. T., Bhalla, A. S., & Shameem, M. (2025) · Methods · doi:10.1016/j.ymeth.2025.02.003 · Cited by 7

Regulatable Complement Inhibition of the Alternative Pathway Mitigates Wet Age-Related Macular Degeneration Pathology in a Mouse Model

Parsons, N., Annamalai, B., & Rohrer, B. (2023) · Translational Vision Science & Technology · doi:10.1167/tvst.12.7.17 · Cited by 6

An Engineered Intravitreal Injection Retinal-Pigment-Epithelium-Tropic Adeno-Associated Virus Vector Expressing a Bispecific Antibody Binding VEGF-A and ANG-2 Rescues Neovascular Age-Related Macular Degeneration in Animal Models and Patients

Cai, Y., Gu, Y., Zhang, J., Zhu, Y. Y., Ma, Z., He, Q., Sun, Y. J., Yuan, M., Li, X., Zhu, K., et al. (2025) · Research · doi:10.34133/research.0717 · Cited by 5

Targeting the gut-retina axis: mechanistic insights and therapeutic prospects for diabetic retinopathy

Jiang, Y. Z., Tang, Y., Liu, Z., Yang, X., Zhou, M.-Y., Liang, Y., Ding, J., & Liao, Y. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-02022-3 · Cited by 5

Advances in Regenerative Medicine, Cell Therapy, and 3D Bioprinting for Glaucoma and Retinal Diseases

Wu, K. Y., Osman, R. M., Esomchukwu, O., Marchand, M., Nguyen, B. H., & Tran, S. D. (2025) · Advances in experimental medicine and biology · doi:10.1007/5584_2025_854 · Cited by 5

Nanotechnology-Based Delivery Systems and Retinal Pigment Epithelium: Advances, Targeting Approaches, and Translational Challenges

Nardella, M., Pellegrini, M., Yu, A. C., Adamo, G., Mura, M., & Busin, M. (2025) · Biomolecules · doi:10.3390/biom15111592 · Cited by 4

Gene Therapy for Inherited Retinal Disease: Current Strategies, Personalized Medicine, and Future Implications—A Comprehensive Review

Butt, F. R., Dhivagaran, T., Li, B., Ashamalla, M., Tao, B. K.-L., Balas, M., Pereira, A., Yan, P., & Arjmand, P. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15120619 · Cited by 6

Techniques for subretinal injections in animals

Boyd, R. F., & Petersen‐Jones, S. M. (2024) · Veterinary Ophthalmology · doi:10.1111/vop.13219 · Cited by 4

Metabolic plasticity in a Pde6bSTOP/STOP retinitis pigmentosa mouse model following rescue

Ayten, M., Díaz‐Lezama, N., Ghanawi, H., Haffelder, F. C., Kajtna, J., Straub, T., Borsò, M., Imhof, A., Hauck, S. M., & Koch, S. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101994 · Cited by 4

How Advanced are Nanocarriers for Effective Subretinal Injection?

Guan, J.-X., Wang, Y.-L., & Wang, J. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s479327 · Cited by 4

Insights into the effects of subretinal voretigene neparvovec-rzyl in RPE65-associated Leber congenital amaurosis

Tayyib, A., Parameswarappa, D. C., Kertes, P. J., Muni, R. H., Tumber, A. K., Costain, G., Schramm, A., MacDonald, H. R., Klatt, R., Vincent, A., et al. (2025) · Canadian Journal of Ophthalmology · doi:10.1016/j.jcjo.2024.12.006 · Cited by 4

Assessment of the Orbit® subretinal delivery system (Orbit® SDS device) and prototypes in adult and juvenile canine eyes

Kwok, J., Gray, A. P., Sato, Y., Savina, S. V., Dolgova, N., Sudharsan, R., Boye, S. L., Boye, S. L., Reichenbacker, S., Meyer, T., et al. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01929-2 · Cited by 3

Robotic augmentation of surgical skills in subretinal injection: a novel semiautomated system

Lian, Z., Xu, A., Li, Y., Liu, J., Song, R., Liang, H., Wang, R., Yang, Y., Wei, X., Zhang, Z., et al. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000004501 · Cited by 3

First pilot study of intravenous rAAV-PAX6 gene therapy increases retinal-ganglion-cell-layer thickness and Notch1 transcription in a mouse model of aniridia

Djaksigulova, D., Kaad, S. G., Korecki, A. J., Lam, S. L., Lengyell, T. C., & Simpson, E. M. (2026) · Gene Therapy · doi:10.1038/s41434-026-00605-5 · Cited by 3

Advancing nanoparticle delivery studies: flow cytometry-based quantification of nanoparticle uptake and transfection in retinal tissue

Paoletti, L., Clerck, K. D., Coster, E. D., Matricardi, P., Remaut, K., & Peynshaert, K. (2025) · Drug Delivery and Translational Research · doi:10.1007/s13346-025-01921-w · Cited by 3

Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice

Tun, S. B. B., Shepherdson, E., Tay, H. G., & Barathi, V. A. (2023) · Journal of Visualized Experiments · doi:10.3791/65848 · Cited by 3

Stem cell therapy in retinal diseases: current evidence

Rubinato, L., Zan, E. R. D., Sarao, V., Veritti, D., & Lanzetta, P. (2023) · Expert Review of Ophthalmology · doi:10.1080/17469899.2023.2296895 · Cited by 3

CLINICAL FEATURES AND OUTCOMES OF LATE RECURRENT RHEGMATOGENOUS RETINAL DETACHMENT

Ghalibafan, S., Volante, V. A. S., Kim, C. K., Rohowetz, L. J., Flynn, H. W., & Yannuzzi, N. A. (2025) · Retina · doi:10.1097/iae.0000000000004472 · Cited by 2

Advances in technical methods and applications of subretinal injections in experimental animals

Song, C., Ji, Y., Wang, Y., & Yang, W. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1574519 · Cited by 2

Local microglial activation induced and labeled in the retina in a novel subretinal hemorrhage mouse model

Balogh, B., Zille, M., Szarka, G., Péntek, L., Futácsi, A., Völgyi, B., & Kovács‐Öller, T. (2025) · Scientific Reports · doi:10.1038/s41598-025-09007-w · Cited by 2

Tropism and Retinal Transduction Efficiency of Adeno-Associated Virus Serotypes in Mice

Wu, W., McRae, J., Brown, A., & Agbaga, M. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.12.18 · Cited by 2

Lipid nanoparticle mediated delivery of dsDNA to the murine retina

Fehrman, R. L., Sahel, D. K., Sahay, G., Lipinski, D. M., & Ryals, R. C. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114194 · Cited by 2

The Co-Transduction Conundrum: Improving Dual rAAV Delivery Through Co-Administration of Capsid Serotypes With Complementary Tropism

Fehrman, R. L., & Lipinski, D. M. (2025) · Translational Vision Science & Technology · doi:10.1167/tvst.14.11.38 · Cited by 2

mRNA therapy: A novel approach for retinal neurodegenerative diseases

Zhang, B., Tang, J., Zhang, Q., Qiu, Y., Cheng, Y., Yu, S., Liu, L., Xue, J., Liu, X., He, Q., et al. (2026) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-01306 · Cited by 2

Extracellular vesicles in ophthalmology: innovations in diagnosis, therapy, and drug delivery

Aziziyan, F., Mahdipour, M., Hadi, B., Asl, S. S., Afkhami, H., & Sheykhhasan, M. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11575-7 · Cited by 2

mRNA delivery to the retina restores REP1 function in choroideremia

de Lemos, L., Antas, P., Carvalho, C., Castro, M., Bruno, D., Fonseca, A. F., Rakshit, S., & Seabra, M. C. (2026) · Molecular Therapy Advances · doi:10.1016/j.omta.2026.201768 · Cited by 2

Myopic Macular Hole and Detachment after Gene Therapy in Atypical RPE65 Retinal Dystrophy: A Case Report

Giansanti, F., Nicolosi, C., Giorgio, D., Sodi, A., Mucciolo, D. P., Pavese, L., Pollazzi, L., Virgili, G., Vicini, G., Passerini, I., et al. (2024) · Genes · doi:10.3390/genes15070879 · Cited by 2

Gene Therapy in Age-related Macular Degeneration

Zhou, H. W., & Kim, L. A. (2025) · International Ophthalmology Clinics · doi:10.1097/iio.0000000000000567 · Cited by 2

A hypomorphic variant of choroideremia is associated with a novel intronic mutation that leads to exon skipping

Waldock, W. J., Taylor, L. J., Sperring, S., Staurenghi, F., de la Cámara, C. M.-F., Whitfield, J., Clouston, P., Yusuf, I. H., & MacLaren, R. E. (2024) · Ophthalmic Genetics · doi:10.1080/13816810.2023.2270554 · Cited by 2

Fiber-Based OCT Guided Subretinal Injection in Ex-Vivo Mice Eyes

Davani, S., Larrivée, B., & Boutopoulos, C. (2025) · Photonics North (PN) · doi:10.1109/pn66844.2025.11097167 · Cited by 1

Ocular Pharmacokinetic Studies: Challenges and Best Practices

Bacellar‐Galdino, M., Jain, S. K., & Kaja, S. (2025) · Pharmaceutical science. · doi:10.5772/intechopen.1011599 · Cited by 1

Real-Time 3D Needle Guidance Using Dynamic Spiral OCT Scanning and Shape-Driven Pose Extraction in Retinal Interventions

Xu, P., Ourak, M., Borghesan, G., Clerck, I. D., Costa, D. R. D., Haegemans, J., Stalmans, P., & Poorten, E. V. (2025) · IEEE Robotics and Automation Letters · doi:10.1109/lra.2025.3641814 · Cited by 1

Advances in microneedle Technology for Treatment of retinal degenerative diseases: a narrative review

Zong, Y., Liu, J., Yang, M., Zhang, J., Zou, Y., Ye, Z., Deng, J., Gu, W., Du, J., Ohno‐Matsui, K., et al. (2026) · Biomedical Microdevices · doi:10.1007/s10544-025-00786-7 · Cited by 1

Gene therapy outcomes in young patients with RPE65-retinal degeneration

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MegaEye: Applying multiple machine learning approaches to identify oral compounds with ocular bioactivity

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Comparative efficacy of subretinal and intravitreal conbercept injections in polypoidal choroidal vasculopathy

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Analysis of Performance Differences Between Self-Developed Fundus Surgery Image Evaluation Software and Kinovea in Ophthalmic MicrosurgeryPreprint

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Ultrasound-Enhanced Retinal Delivery of Engineered Viral Vectors

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A theoretical and experimental model of flow characteristics in subretinal injections

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Physics-Based iOCT Sonification for Real-Time Interaction Awareness in Subretinal Injection

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