Metabolic Flexibility and Inflexibility: Pathology Underlying Metabolism Dysfunction

Metabolic Flexibility in Health and Disease

Goodpaster, B. H., & Sparks, L. M. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.015 · Cited by 995

The use of carbohydrates during exercise as an ergogenic aid

Cermak, N. M., & van Loon, L. J. C. (2013) · Sports Medicine · doi:10.1007/s40279-013-0079-0 · Cited by 300

Benefits of Resistance Training in Early and Late Stages of Frailty and Sarcopenia: A Systematic Review and Meta-Analysis of Randomized Controlled Studies

Talar, K., Hernández‐Belmonte, A., Větrovský, T., Šteffl, M., Kałamacka, E., & Courel‐Ibáñez, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081630 · Cited by 205

PET imaging reveals distinctive roles for different regional adipose tissue depots in systemic glucose metabolism in nonobese humans

Ng, J. M., Azuma, K., Kelley, C. A., Pencek, R., Rádiková, Ž., Laymon, C. M., Price, J. C., Goodpaster, B. H., & Kelley, D. E. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00282.2012 · Cited by 71

Changes in Body Composition Are Associated with Metabolic Changes and the Risk of Metabolic Syndrome

Oh, Y. H., Choi, S., Lee, G., Son, J. S., Kim, K. H., & Park, S. M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040745 · Cited by 63

Magnitude and duration of excess of post‐exercise oxygen consumption between high‐intensity interval and moderate‐intensity continuous exercise: A systematic review

Panissa, V. L. G., Fukuda, D. H., Staibano, V., Marques, M., & Franchini, E. (2021) · Obesity Reviews · doi:10.1111/obr.13099 · Cited by 59

Metabolic inflexibility during submaximal aerobic exercise is associated with glucose intolerance in obese older adults

Prior, S. J., Ryan, A. S., Stevenson, T. G., & Goldberg, A. P. (2013) · Obesity · doi:10.1002/oby.20609 · Cited by 52

Differences in muscle energy metabolism and metabolic flexibility between sarcopenic and nonsarcopenic older adults

Shoemaker, M. E., Pereira, S. L., Mustad, V. A., Gillen, Z. M., McKay, B. D., Lopez‐Pedrosa, J. M., Rueda, R., & Cramer, J. T. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12932 · Cited by 43

Measuring Postprandial Metabolic Flexibility to Assess Metabolic Health and Disease

Yu, E. A., Le, N., & Stein, A. D. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab263 · Cited by 29

An Inverse Relation between Hyperglycemia and Skeletal Muscle Mass Predicted by Using a Machine Learning Approach in Middle-Aged and Older Adults in Large Cohorts

Wu, X., & Park, S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10102133 · Cited by 28

The acute effects of thermogenic fitness drink formulas containing 140 mg and 100 mg of caffeine on energy expenditure and fat metabolism at rest and during exercise

Clark, N. W., Wells, A. J., Coker, N. A., Goldstein, E. R., Herring, C. H., Starling‐Smith, T. M., Varanoske, A. N., Panissa, V. L. G., Stout, J. R., & Fukuda, D. H. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-0341-4 · Cited by 17

Alterations in energy system contribution following upper body sprint interval training

Monica, M. B. L., Fukuda, D. H., Starling‐Smith, T. M., Clark, N. W., & Panissa, V. L. G. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04304-w · Cited by 15

Evaluation of Aerobic Exercise Intensity in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus

Schwaab, B., Windmöller, M., König, I. R., & Schütt, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092773 · Cited by 11

Acute Response to Capsiate Supplementation at Rest and during Exercise on Energy Intake, Appetite, Metabolism, and Autonomic Function: A Randomized Trial

Rossi, P. A. Q., Lira, F. S., Bezerra, V. R., Clark, N. W., Fukuda, D. H., & Panissa, V. L. G. (2021) · Journal of the American Nutrition Association · doi:10.1080/07315724.2021.1938294 · Cited by 9

Similar Adaptations to 10 Weeks Concurrent Training on Metabolic Markers and Physical Performance in Young, Adult, and Older Adult Women

Andrade, D. C., Flores‐Opazo, M., Peñailillo, L., Delgado‐Floody, P., Cano-Montoya, J., Vásquez-Gómez, J., & Álvarez, C. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10235582 · Cited by 8

Impact of slow versus rapid digesting carbohydrates on substrate oxidation in pre-pubertal children: A randomized crossover trial

Gillen, Z. M., Mustad, V. A., Shoemaker, M. E., McKay, B. D., Leutzinger, T. J., López-Pedrosa, J. M., Rueda, R., & Cramer, J. T. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.05.004 · Cited by 6

Body Composition, Fasting Blood Glucose and Lipidemic Indices Are Not Primarily Determined by the Nutritional Intake of Middle-Aged Endurance Trained Men—Another “Athletes’ Paradox”?

Methenitis, S. K., Feidantsis, K. G., Kaprara, A., Hatzitolios, A. I., Skepastianos, P., Papadopoulou, S. Κ., & Panayiotou, G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11206057 · Cited by 6

Metabolic Syndrome and Functional Fitness Abilities

Gallardo-Alfaro, L., Bibiloni, M. D. M., Argelich, E., Angullo-Martínez, E., Bouzas, C., & Tur, J. A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245840 · Cited by 4

Impact of Adipose Tissue and Lipids on Skeletal Muscle in Sarcopenia

Jang, S. Y., & Choi, K. M. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70000 · Cited by 81

Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging

Tero-Vescan, A., Degens, H., Matsakas, A., Ștefănescu, R., Ősz, B. E., & Slevin, M. (2025) · Pharmaceuticals · doi:10.3390/ph18081222 · Cited by 44

Key Roles of Brown, Subcutaneous, and Visceral Adipose Tissues in Obesity and Insulin Resistance

Dobre, M.-Z., Vîrgolici, B., & Timnea, O. C. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47050343 · Cited by 49

Physiological Perturbations in Combat Sports: Weight Cycling and Metabolic Function—A Narrative Review

Lebron, M. A., Stout, J. R., & Fukuda, D. H. (2024) · Metabolites · doi:10.3390/metabo14020083 · Cited by 25

microRNA-1 regulates metabolic flexibility by programming adult skeletal muscle pyruvate metabolism

Ismaeel, A., Peck, B. D., Montgomery, M. M., Burke, B. I., Goh, J. Z., Kang, G., Burrows-Franco, A., Xia, Q., Goljanek‐Whysall, K., McDonagh, B., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102182 · Cited by 13

Exercise Testing for Metabolic Flexibility: Time for Protocol Standardization

Lovell, D. I., Stuelcken, M., & Eagles, A. N. (2025) · Sports Medicine - Open · doi:10.1186/s40798-025-00825-w · Cited by 14

Tau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss

Irmen, R. E., Turner, S. M., Snipes, J. A., Schloss, K. H., Wang, X., Williams, H. C., Velmurugan, G. V., Hunt, J. B., Li, J., Sullivan, P. G., et al. (2026) · npj Dementia · doi:10.1038/s44400-025-00054-8 · Cited by 10

Predicting Glycemic Control in Patients With Impaired Fasting Glucose With Fasting Respiratory Exchange Ratio

Foppiani, A., Sileo, F., Menichetti, F., Pozzi, G., Gallosti, S., Amicis, R. S. D., Leone, A., Bertoli, S., & Battezzati, A. (2025) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaf047 · Cited by 4

Tissue-specific adaptations to cytochrome c oxidase deficiency shape physiological outcomes

Popović, M., Isermann, L., Geißen, S., Senft, K., Georgomanolis, T., Baldus, S. E., Frezza, C., & Trifunović, A. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167567 · Cited by 4

Maternal metabolizable energy intake during late gestation affects energy metabolism of the skeletal muscle of beef offspring

Kladt, L. V., Jiang, M., Li, Z., Veloso, C. M., Hare, K. S., da Silva, W., Wood, K. M., Serão, N. V. L., Gionbelli, M. P., Steele, M. A., et al. (2025) · Journal of Animal Science · doi:10.1093/jas/skaf203 · Cited by 3

The effects of initiating a 24-hour fast with a low versus a high carbohydrate shake on glycemic control in older adults: a randomized crossover study

Gipson, E. Z., Deru, L. S., Graves, P. G., Jacobsen, C. G., Peterson, N. E., & Bailey, B. W. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-00920-5 · Cited by 3

Effects of Exercise Snack Program on Quality of Life, Cardiorespiratory Fitness, and Metabolic Flexibility in Elderly Cancer Survivors: A Preliminary Study

Zhou, P., Hu, Z., Kim, T.-S., Kim, Y., Leng, Z., & Choi, M. (2025) · Life · doi:10.3390/life15091401 · Cited by 3

Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalancePreprint

Irmen, R. E., Turner, S. M., Snipes, J. A., Williams, H. C., Velmurugan, G. V., Hunt, J. B., Li, J., Sullivan, P. G., Lee, D. C., Johnson, L. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.25.666872 · Cited by 2

From the Plate to the Nucleus: Dietary Control of Nuclear Receptors in the Development and Prevention of Metabolic Diseases

Torre-Villalvazo, I., Tovar‐Palacio, C., Díaz‐Villaseñor, A., & Palacios‐González, B. (2026) · Receptors · doi:10.3390/receptors5020012 · Cited by 1

Exercise‐Induced Extracellular Vesicles as Mediators of Mitochondrial Biogenesis and Insulin Sensitivity in Metabolic Adaptation

Wang, J., & Wu, L. (2026) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.70257 · Cited by 1

Is maximal oxygen consumption an appropriate metric for metabolic health?

Lovell, D. I., Stuelcken, M., & Eagles, A. N. (2025) · European Journal of Applied Physiology · doi:10.1007/s00421-025-05875-2 · Cited by 1

Personalized Resistance Exercise With Peer Support for Women With PCOS Using a Smart Home Video Device: Pilot Randomized Controlled Trial Guided by Self‐Determination Theory

Wright, P. J., Corbett, C. F., & Wang, K. (2025) · Advances in Public Health · doi:10.1155/adph/3876104

Supplementation with resveratrol modified gut microbiota improving insulin sensitivity and lipid metabolism in subjects with obesity and insulin resistance

Guevara‐Cruz, M., Sánchez‐Tapia, M., Velázquez‐Villegas, L. A., Torre-Villalvazo, I., Guizar-Heredia, R., Godinez-Salas, E. T., López‐Barradas, A. M., Granados, O., Torres‐Villalobos, G., Torres, N., et al. (2025) · European Journal of Nutrition · doi:10.1007/s00394-025-03850-3

Higher Long-term Variability in Relative Fat Mass is Associated with Lower Cardiovascular Disease Risk in Middle-aged and Older AdultsPreprint

Jia, S., Cao, K., & Wang, L. (2026) · Research Square · doi:10.21203/rs.3.rs-9232970/v1

The Motor Neuromuscular Axis: The Overlooked Element of Developmental Programming in Diabetes and Metabolic Syndrome

Zazula, M. F., Carvalhal, S. R. S., Maciel, D. T., Moritz, D., Beirauti, H. Y. I., Amorim, L., Rocha, M. T., Maciel, M., Sales, O., Dobgenski, P., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27136049

Early life nutrition and prenatal programming: Shaping carcass composition and meat quality

Costa, T. C., Lopes, M. M., Nascimento, K. B., Rodrigues, L. S., Kladt, L. V., Saraiva, A., Gionbelli, M. P., & Duarte, M. (2026) · Meat Science · doi:10.1016/j.meatsci.2026.110170

Coffee and coffee-derived bioactive compounds in skeletal muscle health: a scoping review of mechanistic pathways, preclinical evidence and human outcomes

Fernández-Cardero, Á., Esteves-Mesquita, V., Sarriá, B., & Bravo, L. (2026) · Food & Function · doi:10.1039/d6fo02600a

Whole-Room Indirect Calorimetry in the Study of Obesity, Insulin Resistance and Metabolic Flexibility: A Narrative Review

Zahorodnii, A., Jelska, A., Głuszyńska, P., Almltashe, L. M. M., & Hady, H. R. (2026) · Nutrients · doi:10.3390/nu18193287

Metabolic exhaustion underlies sarcopenic obesity susceptibility in aging mice as revealed by multi-omics factor analysis

LORENZO, R. D., Sciorati, C., Avola, A., Versiglia, A., Damanti, S., Locatelli, A., Stefanoni, D., Pagani, A., Pettinato, M., Silvestri, L., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117831 · Cited by 1

1609-P: Whole-Body Metabolic Flexibility Is Discordant with Skeletal Muscle Metabolism

Krassovskaia, P. M., Jevtovic, F., Chorzepa, M., Jones, T. E., Tanner, C. J., ZHENG, D., Pories, W. J., Dohm, L. G., Houmard, J. A., & Broskey, N. T. (2024) · Diabetes · doi:10.2337/db24-1609-p

Metabolic flexibility

Storlien, L., Oakes, N. D., & Kelley, D. E. (2004) · Proceedings of the Nutrition Society · doi:10.1079/pns2004349 · Cited by 291

Editorial: Metabolic Flexibility

Galgani, J. E., Bergouignan, A., Rieusset, J., Moro, C., & Nazare, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.946300 · Cited by 9

Metabolic Flexibility in Health and Disease

Goodpaster, B. H., & Sparks, L. M. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.015 · Cited by 995

Metabolic Inflexibility Revisited: Muscle Substrate Oxidation Is Dissociated From Muscle Insulin Resistance

Song, J. D. (2019)