It’s More Than a Blood Test: Patients’ Perspectives on Noninvasive Prenatal Testing
Open accessAbstract
Noninvasive prenatal testing (NIPT) offers pregnant women a new risk assessment tool for fetal aneuploidy that is superior to conventional screening tests. We conducted focus groups with women who were currently pregnant or had recently delivered in the past year to characterize their perspectives about NIPT and to explore factors they would consider during decision making about its use. Women identified accuracy, early timing, testing ease, and determination of fetal sex as advantages of NIPT over other screens, and the noninvasive method of NIPT as an advantage over diagnostic tests. False positive and false negative results, anxiety, cost and insurance coverage were seen as disadvantages of NIPT. Women who do not want fetal aneuploidy information most likely will not undergo NIPT, despite its advantages over other screening tests. However, given its advantages, the decision to have NIPT is straightforward for women who want genetic information about the fetus. Women emphasized the need to make autonomous, private, and informed choices about NIPT, as they would with any prenatal genetic testing option. These perspectives may guide clinicians to conduct effective and clinically relevant counseling with pregnant women who consider utilizing this new genetic technology.
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Quotes from women from interviews or focus groups on waiting time and accuracy of test results correspond to van Schendel et al.'s findings from questionnaires: waiting time was experienced as long and/or stressful, and women had a high confidence in negative NIPT results.
“Quotes from women from interviews (Vanstone et al. [25]) or focus groups (Farrell et al. [19]) on the aspects of waiting time and accuracy of test results correspond to Van Schendel et al.’s findings from questionnaires: Waiting time was experienced as long and/or stressful, and women had a high confidence in negative NIPT results.”
From Psychological and social consequences of non-invasive prenatal testing (NIPT): a scoping review (2019) · cites this paper as [19]
The scoping review identified seven studies that investigated psychological and/or social consequences after NIPT.
“In this scoping review, we identified seven studies that investigated psychological and/or social consequences after NIPT [19–25].”
From Psychological and social consequences of non-invasive prenatal testing (NIPT): a scoping review (2019) · cites this paper as [19]
Two included studies assessed women's experiences with and feelings after NIPT in interviews or focus groups.
“Two studies assessed women’s experiences with and feelings after NIPT in interviews or focus groups [19, 25].”
From Psychological and social consequences of non-invasive prenatal testing (NIPT): a scoping review (2019) · cites this paper as [19]
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- Authors
- Farrell, R., Mercer, M., Agatisa, P., Smith, M., & Philipson, E.
- Affiliations
- Cleveland Clinic (US)
- Corresponding author
- Farrell, Ruth
- Venue
- Journal of Clinical Medicine
- Publisher
- MDPI AG
- Published
- 2014-06-19
- Volume
- 3
- Issue
- 2
- Pages
- 614-631
- ISSN
- 2077-0383 (ISSN-L)
- PMC
- PMC4449684
- OpenAlex
- W1975810962
- Cited by
- 47
- References
- 35
- Citations by year
- 2025: 3 · 2024: 3 · 2023: 5 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 1
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Clinical Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- March of Dimes Foundation (12-FY13-293)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- non-invasive prenatal testing, patient perspectives, fetal aneuploidy, prenatal genetic testing, informed consent, genetic counseling, decision-making, fetal sex determination, false positives, anxiety, autonomy
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