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Cited by 70Clinical Nutrition and GastroenterologySepsis Diagnosis and TreatmentIntensive Care Unit Cognitive Disorders

Protein Intake, Nutritional Status and Outcomes in ICU Survivors: A Single Center Cohort Study

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Weijs, Peter J.M., Mogensen, Kris M., Rawn, James D., Christopher, Kenneth B.·2019·Journal of Clinical Medicine
DOI 10.3390/jcm8010043PMC PMC6352154
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Abstract

Background: We hypothesized that protein delivery during hospitalization in patients who survived critical care would be associated with outcomes following hospital discharge. Methods: We studied 801 patients, age ≥ 18 years, who received critical care between 2004 and 2012 and survived hospitalization. All patients underwent a registered dietitian formal assessment within 48 h of ICU admission. The exposure of interest, grams of protein per kilogram body weight delivered per day, was determined from all oral, enteral and parenteral sources for up to 28 days. Adjusted odds ratios for all cause 90-day post-discharge mortality were estimated by mixed- effects logistic regression models. Results: The 90-day post-discharge mortality was 13.9%. The mean nutrition delivery days recorded was 15. In a mixed-effect logistic regression model adjusted for age, gender, race, Deyo-Charlson comorbidity index, acute organ failures, sepsis and percent energy needs met, the 90-day post-discharge mortality rate was 17% (95% CI: 6–26) lower for each 1 g/kg increase in daily protein delivery (OR = 0.83 (95% CI 0.74–0.94; p = 0.002)). Conclusions: Adult medical ICU patients with improvements in daily protein intake during hospitalization who survive hospitalization have decreased odds of mortality in the 3 months following hospital discharge.

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  • More recent studies in medical ICU patients reported a positive correlation between early or high protein intake and decreased odds of mortality.

    “More recent studies in medical ICU patients reported a positive correlation between early [25] or high [26] protein intake and decreased odds of mortality.”

    From Nutrition in Sepsis: A Bench-to-Bedside Review. (2020) · cites this paper as [26]

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References 41 · Cited by 70

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Authors
Weijs, P. J. M., Mogensen, K. M., Rawn, J. D., & Christopher, K. B.
Affiliations
  • Amsterdam University Medical Centers (NL)
  • Brigham and Women's Hospital (US)
Corresponding author
Christopher, Kenneth B.
ORCID
Venue
Journal of Clinical Medicine
Publisher
MDPI AG
Published
2019-01-04
Volume
8
Issue
1
Pages
43
ISSN
2077-0383 (ISSN-L)
DOI
10.3390/jcm8010043
PMC
PMC6352154
OpenAlex
W2908199995
Cited by
70
References
41
Citations by year
2026: 4 · 2025: 9 · 2024: 9 · 2023: 6 · 2022: 8 · 2021: 12 · 2020: 15 · 2019: 7
FWCI
7.99
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Clinical Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, cc-by)
  • Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • OpenBU (Boston University) (submittedVersion, cc-by)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders
National Institutes of Health (R01GM115774)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords
protein intake, critical illness, intensive care unit survivors, post-discharge mortality, nutritional status, enteral nutrition, parenteral nutrition, nutritional assessment, registered dietitians, 90-day mortality, energy demand

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