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Cited by 190Clinical Nutrition and GastroenterologyNutrition and Health in AgingSepsis Diagnosis and Treatment

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Nutritional Status and Mortality in the Critically Ill*

Mogensen, Kris M., Robinson, Malcolm K., Casey, Jonathan D., Gunasekera, Nicole S., Moromizato, Takuhiro, Rawn, James D., Christopher, Kenneth B.·2015·Critical Care Medicine
DOI 10.1097/ccm.0000000000001306
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Abstract

OBJECTIVES: The association between nutritional status and mortality in critically ill patients is unclear based on the current literature. To clarify this relation, we analyzed the association between nutrition and mortality in a large population of critically ill patients and hypothesized that mortality would be impacted by nutritional status. DESIGN: Retrospective observational study. SETTING: Single academic medical center. PATIENTS: Six thousand five hundred eighteen adults treated in medical and surgical ICUs between 2004 and 2011. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: All cohort patients received a formal, in-person, standardized evaluation by a registered dietitian. The exposure of interest, malnutrition, was categorized as nonspecific malnutrition, protein-energy malnutrition, or well nourished and determined by data related to anthropometric measurements, biochemical indicators, clinical signs of malnutrition, malnutrition risk factors, and metabolic stress. The primary outcome was all-cause 30-day mortality determined by the Social Security Death Master File. Associations between nutrition groups and mortality were estimated by bivariable and multivariable logistic regression models. Adjusted odds ratios were estimated with inclusion of covariate terms thought to plausibly interact with both nutrition status and mortality. We used propensity score matching on baseline characteristics to reduce residual confounding of the nutrition status category assignment. In the cohort, nonspecific malnutrition was present in 56%, protein-energy malnutrition was present in 12%, and 32% were well nourished. The 30-day and 90-day mortality rates for the cohort were 19.1% and 26.6%, respectively. Nutritional status is a significant predictor of 30-day mortality following adjustment for age, gender, race, medical versus surgical patient type, Deyo-Charlson index, acute organ failure, vasopressor use, and sepsis: nonspecific malnutrition 30-day mortality odds ratio, 1.17 (95% CI, 1.01-1.37); protein-energy malnutrition 30-day mortality odds ratio, 2.10 (95% CI, 1.70-2.59), all relative to patients without malnutrition. In the matched cohort, the adjusted odds of 30-day mortality in the group of propensity score-matched patients with protein-energy malnutrition was two-fold greater than that of patients without malnutrition. CONCLUSION: In a large population of critically ill adults, an association exists between nutrition status and mortality.

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  • In a large cohort study (6,518 patients), Mogensen et al. found a significant increase in 30, 90 and 365 days mortality in the nonspecific and protein calorie malnourished groups compared with non-malnourished patients.

    “In a large cohort study (6,518 patients), Mogensen et al. (21) followed survival in non-malnourished (2,123 patients), non-specific malnourished (3,641 patients) and protein calorie malnourished patients (754 patients) and found a significant increase in 30, 90 and 365 days mortality in the nonspecific and protein calorie malnourished groups”

    From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [21]

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Metadata

Authors
Mogensen, K. M., Robinson, M. K., Casey, J. D., Gunasekera, N. S., Moromizato, T., Rawn, J. D., & Christopher, K. B.
Affiliations
  • Brigham and Women's Hospital (US)
  • Harvard University (US)
  • Okinawa Hokubu Hospital (JP)
ORCID
Venue
Critical Care Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-12
Volume
43
Issue
12
Pages
2605-2615
ISSN
0090-3493 (ISSN-L)
DOI
10.1097/ccm.0000000000001306
OpenAlex
W2323887451
Cited by
190
References
4
Citations by year
2026: 11 · 2025: 20 · 2024: 14 · 2023: 18 · 2022: 20 · 2021: 20 · 2020: 21 · 2019: 21 · 2018: 20 · 2017: 12 · 2016: 11 · 2015: 2
FWCI
14.46
Type
journal article
Language
en
Open access
closed
Locations
  • Critical Care Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Keywords
nutritional status, malnutrition, protein-energy malnutrition, critically ill patients, mortality, intensive care unit, 30-day mortality, nutritional risk factors, metabolic stress
MeSH terms
Academic Medical Centers, Adult, Age Factors, Aged, Aged, 80 and over, Female, Humans, Intensive Care Units, Male, Middle Aged, Nutritional Status, Retrospective Studies, Risk Factors, Severity of Illness Index, Sex Factors, Comorbidity, Critical Illness, Malnutrition, Propensity Score

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