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Cited by 21Lipoproteins and Cardiovascular HealthCardiovascular Health and Disease PreventionDiabetes, Cardiovascular Risks, and Lipoproteins

Association between Very Low-Density Lipoprotein Cholesterol (VLDL-C) and Carotid Intima-Media Thickness in Postmenopausal Women Without Overt Cardiovascular Disease and on LDL-C Target Levels

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Gentile, Marco, Iannuzzi, Arcangelo, Giallauria, Francesco, D’Andrea, Antonello, Venturini, Elio, Pacileo, Mario, Covetti, Giuseppe, Panico, Camilla +7 more·2020·Journal of Clinical Medicine
DOI 10.3390/jcm9051422PMC PMC7290892
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Abstract

Background: atherosclerotic process inexorably advances in patients reaching low-density lipoprotein cholesterol (LDL-C) targets. An attractive hypothesis is that lipoprotein particles (very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL)), could contribute to residual risk. The present study aims to investigate the relationship between carotid intima-media thickness (IMT) and different lipoprotein subfractions in a cohort of healthy postmenopausal women. Methods: 75 postmenopausal women, at LDL-C target levels without overt cardiovascular disease, underwent biochemical analyses (including subfraction assay of plasma lipoproteins) and carotid ultrasound examination. Results: a statistically significant correlation between VLDL and carotid IMT (p < 0.001) was found. No significant correlation was found between carotid IMT and LDL-C (p = 0.179), IDL-C (p = 0.815), high-density lipoprotein (HDL) (p = 0.855), and LDL score (p = 0.240). Moreover, IMT is significantly correlated to LDL particle diameter (p = 0.044). After adjusting for age, systolic blood pressure, body mass index, smoking habits, glucose plasma concentration, and Lipoprotein(a) (Lpa) levels, multivariate analysis showed that women in the third tertile of VLDL-C, compared with those in the first tertile, were significantly associated to the highest IMT (p = 0.04). Conclusions: in this cohort of postmenopausal women, VLDL-C was significantly associated to carotid IMT, independent of main cardiovascular risk factors. These findings pave the way for targeting circulating concentrations of VLDL-C to reduce cardiovascular events in patients with target LDL-C levels.

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  • A decrease in atherogenic lipoproteins and sub-fractions is associated with a similar reduction in coronary heart disease.

    “Such a decrease in atherogenic lipoproteins and sub-fractions is also associated with a similar reduction in coronary heart disease [105–107].”

    From Estimating the Effect of Aerobic Exercise Training on Novel Lipid Biomarkers: A Systematic Review and Multivariate Meta-Analysis of Randomized Controlled Trials (2023) · cites this paper as [107]

    The Introduction states that lowering LDL-C is associated with reduced cardiovascular disease, and the Discussion links higher atherogenic remnant levels with cardiovascular events. The paper does not establish that decreases across atherogenic lipoprotein subfractions produce a similar or proportional reduction in coronary heart disease; its own study measured carotid intima-media thickness, not coronary events. No page numbers are available in our copy. (LLM, conf=0.85)

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Authors
Gentile, M., Iannuzzi, A., Giallauria, F., D’Andrea, A., Venturini, E., Pacileo, M., Covetti, G., Panico, C., Mattiello, A., Vitale, G., Sarullo, F. M., Rubba, P., Vigorito, C., Panico, S., & Iannuzzo, G.
Affiliations
  • Federico II University Hospital (IT)
  • Ospedale Antonio Cardarelli (IT)
  • University of Naples Federico II (IT)
  • Cardiology and Intensive Care Units, “Umberto I” Hospital, Viale San Francesco, 84014 Nocera Inferiore (Salerno), Italy
  • Azienda USL Toscana Nord Ovest (IT)
  • Ospedale Buccheri la Ferla Fatebenefratelli (IT)
Corresponding author
Gentile, Marco
ORCID
Venue
Journal of Clinical Medicine
Publisher
MDPI AG
Published
2020-05-11
Volume
9
Issue
5
Pages
1422
ISSN
2077-0383 (ISSN-L)
DOI
10.3390/jcm9051422
PMC
PMC7290892
OpenAlex
W3021628257
Cited by
21
References
3
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 1
FWCI
2.74
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Clinical Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
VLDL cholesterol, carotid intima-media thickness, postmenopausal women, LDL-C target levels, residual cardiovascular risk, lipoprotein subfractions, intermediate density lipoprotein, atherosclerosis, cardiovascular risk factors

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