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Cited by 11Gestational Diabetes Research and ManagementAssisted Reproductive Technology and Twin PregnancyDiabetes, Cardiovascular Risks, and Lipoproteins

Prevalence of Gestational Diabetes in Triplet Pregnancies: A Retrospective Cohort Study and Meta-Analysis

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Hager, Marlene, Ott, Johannes, Castillo, Deirdre Maria, Springer, Stephanie, Seemann, Rudolf, Pils, Sophie·2020·Journal of Clinical Medicine
DOI 10.3390/jcm9051523PMC PMC7290297
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Abstract

Background: Over the last decades, there has been a substantial increase in the incidence of higher-order multiple gestations. Twin pregnancies are associated with an increased risk of gestational diabetes mellitus (GDM). The literature on GDM rates in triplet pregnancies is scarce. Methods: A retrospective cohort study was performed to assess the prevalence of GDM in women with a triplet pregnancy. GDM was defined through an abnormal oral glucose tolerance test (OGTT). A meta-analysis of GDM prevalence was also carried out. Results: A cohort of 60 women was included in the analysis. Of these, 19 (31.7%) were diagnosed with GDM. There were no differences in pregnancy outcomes between women with and without GDM. In the meta-analysis of 12 studies, which used a sound GDM definition, an estimated pooled prevalence of 12.4% (95% confidence interval: 6.9–19.1%) was found. In a leave-one-out sensitivity analysis, the estimated GDM prevalence ranged from 10.7% to 14.1%. Conclusion: The rate of GDM seems increased in women with triplets compared to singleton pregnancies. However, GDM did not impact short-term pregnancy outcomes.

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Cited by

Sorted by citations

Authors
Hager, M., Ott, J., Castillo, D. M., Springer, S., Seemann, R., & Pils, S.
Affiliations
  • Medical University of Vienna (AT)
  • Clinical Division of Gynecologic Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria
  • Comprehensive Cancer Center Vienna (AT)
Corresponding author
Ott, Johannes
ORCID
Venue
Journal of Clinical Medicine
Publisher
MDPI AG
Published
2020-05-18
Volume
9
Issue
5
Pages
1523
ISSN
2077-0383 (ISSN-L)
DOI
10.3390/jcm9051523
PMC
PMC7290297
OpenAlex
W3025740022
Cited by
11
References
5
Citations by year
2026: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 1
FWCI
1.22
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Clinical Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Assisted Reproductive Technology and Twin Pregnancy
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
gestational diabetes mellitus, triplet pregnancy, multiple pregnancy, GDM prevalence, oral glucose tolerance test, pregnancy outcomes

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