The Impact of Korean Medicine Treatment on the Incidence of Parkinson’s Disease in Patients with Inflammatory Bowel Disease: A Nationwide Population-Based Cohort Study in South Korea
Open accessAbstract
We aimed to investigate the association between Korean medicine (KM) treatment and the risk of Parkinson’s Disease (PD) in patients with inflammatory bowel disease (IBD) in South Korea. This study analyzed data from the National Health Insurance Service-Senior cohort in South Korea. The 1816 IBD patients enrolled in the analysis comprised 411 who received only conventional treatment (monotherapy group) and 1405 who received both conventional and KM treatments (integrative therapy group). The risk of PD in patients with IBD was significantly lower in the integrative therapy group than in the monotherapy group after adjusting for confounding variables (adjusted hazard ratio (HR), 0.56; 95% confidence interval (CI) = 0.34–0.92). In the mild Charlson Comorbidity Index (CCI) group, the risk of PD in patients with IBD in the integrative therapy group was 0.39 times lower (adjusted HR, 95% CI = 0.20–0.77) than that in the monotherapy group. However, there was no significant difference in the risk of PD in patients with IBD between the integrative therapy and monotherapy groups among individuals with severe CCI (adjusted HR, 0.90; 95% CI = 0.41−1.96). IBD patients are at a decreased risk of PD when they receive integrative therapy. KM treatment may prevent PD in IBD patients.
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At the same level of pathology, the probability of clinical diagnosis of AD is significantly higher in women than in men.
“At the same level of pathology, the probability of clinical diagnosis of AD was found to be significantly higher in women than in men [69].”
From Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human (2020) · cites this paper as [69]
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- Authors
- Noh, H., Jang, J., Kwon, S., Cho, S.-Y., Jung, W.-S., Moon, S.-K., Park, J.-M., Ko, C.-N., Kim, H., & Park, S.-U.
- Affiliations
- Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea
- Seoul National University (KR)
- Kyung Hee University (KR)
- Corresponding author
- Kim, Ho
- Park, Seong-Uk
- Venue
- Journal of Clinical Medicine
- Publisher
- MDPI AG
- Published
- 2020-07-28
- Volume
- 9
- Issue
- 8
- Pages
- 2422
- ISSN
- 2077-0383 (ISSN-L)
- PMC
- PMC7463832
- OpenAlex
- W3045560532
- Cited by
- 8
- References
- 38
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2020: 1
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Clinical Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2017R1D1A1B03031688)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- traditional Korean medicine, Parkinson's disease, inflammatory bowel disease, integrative therapy, conventional therapy, Parkinson's disease risk, Charlson Comorbidity Index, comorbidities, disease prevention
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