The DOI matches its Crossref record; 310 of the 312 references it cites were found in a registry or an index.
Bone Morphogenetic Protein-2 in Development and Bone Homeostasis
Open accessAbstract
Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Specifically, within the BMP family, Bone Morphogenetic Protein-2 (BMP-2) was the first BMP to be characterized and has been well-studied. BMP-2 has important roles during embryonic development, as well as bone remodeling and homeostasis in adulthood. Some of its specific functions include digit formation and activating osteogenic genes, such as Runt-Related Transcription Factor 2 (RUNX2). Because of its diverse functions and osteogenic potential, the Food and Drug Administration (FDA) approved usage of recombinant human BMP-2 (rhBMP-2) during spinal fusion surgery, tibial shaft repair, and maxillary sinus reconstructive surgery. However, shortly after initial injections of rhBMP-2, several adverse complications were reported, and alternative therapeutics have been developed to limit these side-effects. As the clinical application of BMP-2 is largely implicated in bone, we focus primarily on its role in bone. However, we also describe briefly the role of BMP-2 in development. We then focus on the structure of BMP-2, its activation and regulation signaling pathways, BMP-2 clinical applications, and limitations of using BMP-2 as a therapeutic. Further, this review explores other potential treatments that may be useful in treating bone disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“BMP-2 has known roles in development [36], on tumorigenesis, [37] and in various body tissues [38–40].”
From Keratin Scaffold Formulation Impacts rhBMP-2 Biodistribution and Bone Regeneration in a Rat Femur Defect Model (2025) · cites this paper as [36]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Li, S., Peng, C., & Yang, Q. (2019) · Journal of bone oncology · doi:10.1016/j.jbo.2019.100217 · Cited by 14
RetractedBone: Formation by Autoinduction
Urist, M. R. (1965) · Science · doi:10.1126/science.150.3698.893 · Cited by 5,529
Neer, R. M., Arnaud, C. D., Zanchetta, J. R., Prince, R., Gaich, G. A., Reginster, J.-Y., Hodsman, A. B., Eriksen, E. F., Ish-Shalom, S., Genant, H. K., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105103441904 · Cited by 4,602
TGF-β signalling from cell membrane to nucleus through SMAD proteins
Heldin, C., Miyazono, K., & ten Dijke, P. (1997) · Nature · doi:10.1038/37284 · Cited by 3,697
Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044
Chen, D., Zhao, M., & Mundy, G. R. (2004) · Growth Factors · doi:10.1080/08977190412331279890 · Cited by 1,921
Cummings, S. R., Eckert, S., Krueger, K. A., Grady, D., Powles, T. J., Cauley, J. A., Norton, L., Nickelsen, T., Bjarnason, N. H., Morrow, M., et al. (1999) · JAMA · doi:10.1001/jama.281.23.2189 · Cited by 1,872
TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation
Chen, G., Deng, C., & Li, Y.-P. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.2929 · Cited by 1,756
Khosla, S., Burr, D., Cauley, J., Dempster, D. W., Ebeling, P. R., Felsenberg, D., Gagel, R. F., Gilsanz, V., Guise, T., Koka, S., et al. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.0707onj · Cited by 1,650
Flagged first, then by citations
2 of the 312 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Steele, D.G., and Bramblett, C.A. (1988). The Anatomy and Biology of the Human Skeleton, Texas A&M University Press.
- (2020, April 23). The Basics of Bone in Health and Disease, Available online: https://www.ncbi.nlm.nih.gov/books/NBK45504/.
Cited by
Sorted by citations
Items 101–200 of 348
Clinical Applications of Low-Intensity Pulsed Ultrasound and Its Underlying Mechanisms in Dentistry
Wei, Y., & Guo, Y. (2022) · Applied Sciences · doi:10.3390/app122311898 · Cited by 11
Molecular Interplay in Cardiac Fibrosis: Exploring the Functions of RUNX2, BMP2, and Notch
Docshin, P. M., Паншин, Д. Д., & Malashicheva, A. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2510368 · Cited by 12
mu, A. L. M. K. R., Abulikemu, M., Liang, Z., Abulikemu, A., & Tuxun, A. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s514978 · Cited by 14
Cell-permeable bone morphogenetic protein 2 facilitates bone regeneration by promoting osteogenesis
Kang, M.-G., Lee, S., Seo, J., Lee, E.-B., Ahn, D., Shin, J., Paik, Y., & Jo, D. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.100983 · Cited by 11
Zhang, S., Kutibiding, A., Wang, M., Zhou, X., Tian, X., Liu, D., Manafu, T., Li, R., Guo, H., Zhao, W., et al. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100258 · Cited by 16
Interaction between immuno-stem dual lineages in jaw bone formation and injury repair
Liu, Z., Luo, X., & Xu, R. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1359295 · Cited by 11
Choi, S., Kim, J. H., Kang, T. H., An, Y., Lee, S. J., Hwang, N. S.-Y., & Kim, S. (2024) · Biomaterials Research · doi:10.34133/bmr.0056 · Cited by 11
Mechanisms of Bone Morphogenetic Protein 2 in Respiratory Diseases
Wen, Y., Zheng, Y., Hua, S., Li, T., Bi, X., Lu, Q., Li, M., & Sun, S. (2024) · Current Allergy and Asthma Reports · doi:10.1007/s11882-024-01181-7 · Cited by 10
Yasunaga, M., Kobayashi, F., Sogo, Y., Murotomi, K., Hirose, M., Hara, Y., Yamazaki, M., & Ito, A. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.06.013 · Cited by 10
Atasoy‐Zeybek, A., Coenen, M. J., Hawse, G. P., Logeart‐Avramoglou, D., Evans, C. H., & la Vega, R. E. D. (2023) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2023.03.017 · Cited by 10
Li, S., Zhang, S., Dong, S., Zhao, M., Zhang, W., Zhang, C., & Wu, Z. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.3c01045 · Cited by 10
Dentin Matrix Protein 1 on Titanium Surface Facilitates Osteogenic Differentiation of Stem Cells
Kongkiatkamon, S., Ramachandran, A., Knoernschild, K. L., Campbell, S. D., Sukotjo, C., & George, A. (2021) · Molecules · doi:10.3390/molecules26226756 · Cited by 10
Akter, K., Kim, Y., Choi, E. H., & Han, I. (2024) · Journal of Biological Engineering · doi:10.1186/s13036-024-00419-2 · Cited by 9
The Bone-Vascular Axis: A Key Player in Chronic Kidney Disease Associated Vascular Calcification
Shen, Y., & Yu, C. (2024) · Kidney Diseases · doi:10.1159/000541280 · Cited by 9
Kotsifaki, A., Kalouda, G., Maroulaki, S., Foukas, A. F., & Armakolas, A. (2025) · Diseases · doi:10.3390/diseases13030075 · Cited by 9
Chen, K., Chen, L., Ma, Y., Chen, S., Liu, J., Zhou, H., Chen, Y., & Liu, G. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1614542 · Cited by 10
Westhauser, F., Arango‐Ospina, M., Hupa, L., Renkawitz, T. F., Boccaccini, A. R., & Kunisch, E. (2024) · Biomedical Materials · doi:10.1088/1748-605x/ad2210 · Cited by 9
Can Adding BMP2 Improve Outcomes in Patients Undergoing the SUPERhip Procedure?
Paley, D., Shannon, C. E., Nogueira, M. P., Chiari, C., & Harris, M. (2021) · Children · doi:10.3390/children8060495 · Cited by 9
Hasenbein, I., Sachse, A., Hortschansky, P., Schmuck, K. D., Horbert, V., Anders, C., Lehmann, T., Huber, R., Maslaris, A., Layher, F., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10020513 · Cited by 9
Tao, Y., Geng, Y., Dang, W., Xu, X., Zhao, H. M., Zou, L., & Li, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.856331 · Cited by 9
Zhang, R. Z., Shi, Q., Zhao, H., Pan, G. Q., Shao, L. H., Wang, J. F., & Liu, H. W. (2022) · Journal of Biomaterials Applications · doi:10.1177/08853282221117209 · Cited by 9
Hyc, A., Osiecka‐Iwan, A., & Moskalewski, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810327 · Cited by 9
Chen, J., Sun, Y.-S., Nguyen, D. T., Liu, C.-F., & Huang, H. (2022) · Materials & Design · doi:10.1016/j.matdes.2022.111216 · Cited by 10
A Preview of Selected Articles
Atkinson, S. P. (2017) · Stem Cells · doi:10.1002/stem.2745 · Cited by 9
Notch Signaling in Osteoblast Progenitor Cells is Required for Bmp-Induced Bone Formation
WILSON, H. M., Buckles, M., Acevedo, P. K., Capobianco, C., Nguyen, D. M., Kessell, K., Bergin, I. L., Wagley, Y., Kalajzić, I., & Hankenson, K. D. (2024) · Bone · doi:10.1016/j.bone.2025.117425 · Cited by 10
High-yield BMP2 expression in rice cells via CRISPR and endogenous αAmy3 promoter
Nguyen, T. M., Wu, P., Chang, C.-H., & Huang, L. (2024) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-024-13054-0 · Cited by 8
Vuong, T. A., Zhang, Y., Kim, J., Leem, Y.-E., & Kang, J. (2024) · BMB Reports · doi:10.5483/bmbrep.2023-0203 · Cited by 8
Fukuyasu, S., Kayashima, H., Moribayashi, A., Matsuoka, S., Nagasaki, A., Okawa, H., Yatani, H., Saeki, M., & Egusa, H. (2022) · Biomedicines · doi:10.3390/biomedicines10020426 · Cited by 8
Karyagina, A. S., Orlova, P. A., Poponova, M. S., Bulygina, I. N., Choudhary, R., Zhulina, A. V., Grunina, T. M., Nikitin, K. E., Strukova, N. V., Generalova, M. S., et al. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922110074 · Cited by 8
Ma, Z., Tang, X., Chen, Y., Wang, H., Li, Y., Long, Y., & Liu, R. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/7212642 · Cited by 9
Wijaya, J. H., Tjahyanto, T., Alexi, R., Purnomo, A. E., Rianto, L., Arjuna, Y. Y. E., Tobing, J. F. L., Yunus, Y., & Faried, A. (2023) · European Spine Journal · doi:10.1007/s00586-023-07730-4 · Cited by 8
Jiang, H., Lin, Z., Li, J., Song, T., Zang, H., Li, P., Li, J., Hou, W., Zhou, J., & Li, Y. (2024) · Materials Futures · doi:10.1088/2752-5724/ad66ea · Cited by 7
Li, Q., Li, C., Bie, X., Zhang, J., & Zhao, Y. (2025) · Accounts of Materials Research · doi:10.1021/accountsmr.5c00029 · Cited by 7
Mirbehbahani, F. S., Salehi, M., Zamani, S., Rahmati, M., & Abbaszadeh‐Goudarzi, G. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146730 · Cited by 7
Suzuki, A., Yoshioka, H., Liu, T., Gull, A., Singh, N., Le, T., Zhao, Z., & Iwata, J. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.788259 · Cited by 7
Huang, F., Wang, H., Zhang, Y. E., Wei, G., Xie, Y., & Wu, G. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097707 · Cited by 7
Chiu, K.-Y., Huang, J.-Y., Su, Y., Ou, S., Chen, K.-K., & Wang, Y. (2024) · Materials & Design · doi:10.1016/j.matdes.2024.112898 · Cited by 7
Meglei, A. Y., Nedorubova, I. A., Basina, V. P., Chernomyrdina, V. O., Nedorubov, A. A., Kuznetsova, V. S., Vasilyev, A. V., Kutsev, S. I., Goldshtein, D. V., & Bukharova, T. B. (2024) · Biomedicines · doi:10.3390/biomedicines12112461 · Cited by 7
Evaluation of the Effects of Favipiravir Combined with Vitamin C on Alveolar Bone in Rats
Alpan, A. L., Cin, G. T., Özmen, Ö., Doğan, M. F., & Şahin, Y. (2022) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093022020119 · Cited by 7
Liu, L.-J., Fan, Y., Wang, S.-H., Wu, X., Yang, X. Y., & Sun, L. (2023) · Acta Astronautica · doi:10.1016/j.actaastro.2023.01.039 · Cited by 7
Tian, X., Vater, C., Raina, D. B., Findeisen, L., Matuszewski, L.-M., Tägil, M., Lidgren, L., Winkler, A., Gottwald, R., Modler, N., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.02.034 · Cited by 9
Jaiswal, A. K., Raj, A., Kushawaha, A. K., Maji, B., Bhatt, H., Verma, S., Katiyar, S., Ansari, A., Bisen, A. C., Tripathi, A., et al. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108216 · Cited by 6
Latitude-driven adaptive evolution of body length in diverse pig breeds across China
Wang, Y., Feng, R., Hu, X., Shan, D., Zhang, X., Gou, Y., Zheng, T., Li, Y., Fei, K., Zhang, Q., et al. (2025) · BMC Biology · doi:10.1186/s12915-025-02265-0 · Cited by 6
Application of Biologics in Maxillary Sinus Augmentation Surgery: A Narrative Review
Aghaloo, T. L., Valentini, P., Yardley, R., & Zadeh, H. H. (2025) · Clinical Implant Dentistry and Related Research · doi:10.1111/cid.70004 · Cited by 6
GREM1: Dual roles in cancer and fibrosis with emerging therapeutic opportunities
Elizarrarás-Rivas, J., Elizarrarás-Cruz, J. D., Ramirez-Garcia, S. A., Vásquez-Garzón, V. R., Elizarrarás-Cruz, R., González, A. A. G., Nivon‐Torres, G. F., Guevara‐López, U., García‐Cruz, D., González, E. E. J., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178002 · Cited by 6
Yuan, Y., Zhao, X., Hu, J., Zhu, Y., Deng, X., & Jiang, Q. (2025) · Biomedical Materials · doi:10.1088/1748-605x/ae0778 · Cited by 6
Functional Hydrogels in Bone Tissue Engineering: From Material Design to Translational Applications
Petraglia, F. M., Giordano, S., & Santoro, A. (2026) · Biologics · doi:10.3390/biologics6010002 · Cited by 6
Song, J., Sun, L., Li, F., Wang, D., Yang, S., Ai, Y., Jiang, N., & Song, W. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04043-8 · Cited by 9
Monoallelic loss-of-function BMP2 variants result in BMP2-related skeletal dysplasia spectrum
Priestley, J. R. C., Deshwar, A. R., Murthy, H. R., D’Agostino, D., Dupuis, L., Gangaram, B., Gray, C., Jobling, R. K., Pannia, E., Platzer, K., et al. (2023) · Genetics in Medicine · doi:10.1016/j.gim.2023.100863 · Cited by 6
Santibanez, J. F., Echeverría, C., Millán, C., & Simón, F. (2023) · Acta Histochemica · doi:10.1016/j.acthis.2023.152096 · Cited by 6
Ingwersen, L.-C., Ahlhelm, M., Schwarzer-Fischer, E., Kurz, S., Riemer, E., Naujokat, H., Loger, K., Bader, R., & Jonitz‐Heincke, A. (2024) · Materials & Design · doi:10.1016/j.matdes.2024.112687 · Cited by 6
Jeong, C., Lee, C. H., Seo, J., Park, J. H. Y., & Lee, K. W. (2024) · Fitoterapia · doi:10.1016/j.fitote.2024.106188 · Cited by 6
The Role of Bovine Amniotic Membrane and Hydroxyapatite for the Ridge Preservation
Octarina, O., Munadziroh, E., Razak, F. B. A., Handharyani, E., & Surboyo, M. D. C. (2024) · International Journal of Biomaterials · doi:10.1155/2024/4053527 · Cited by 6
Hirpara, A., Ackert‐Bicknell, C. L., & Patel, V. V. (2024) · Spine · doi:10.1097/brs.0000000000005217 · Cited by 6
Babu, S., Velmani, N. S., Manoharan, S., & Perumal, E. (2024) · Environmental Toxicology · doi:10.1002/tox.24445 · Cited by 6
Mahbub, M. S. I., Park, M., Park, S.-S., Won, M. J., Lee, B.-R., Kim, H.-D., & Lee, B. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141040 · Cited by 6
Salvadori, L., Belladonna, M. L., Castiglioni, B., Paiella, M., Panfili, E., Manenti, T., Ercolani, C., Cornioli, L., Chiappalupi, S., Gentili, G., et al. (2022) · Nutrients · doi:10.3390/nu14153053 · Cited by 6
Differentiation of Cells Isolated from Human Femoral Heads into Functional Osteoclasts
Halloran, D. R., Heubel, B. P., MacMurray, C., Root, D., Eskander, M. S., McTague, S., Pelkey, H., & Nohe, A. (2022) · Journal of Developmental Biology · doi:10.3390/jdb10010006 · Cited by 5
Self-citationZhao, K., Ono, M., Mu, X., Wang, Z., Xie, S., Yonezawa, T., Okada, M., Matsumoto, T., Kuboki, T., & Oohashi, T. (2025) · Regenerative Biomaterials · doi:10.1093/rb/rbae144 · Cited by 5
Campagna, R., Schiavoni, V., Rao, L., Bambini, F., Frontini, A., Sampalmieri, F., Salvolini, E., & Memè, L. (2025) · Materials · doi:10.3390/ma18061234 · Cited by 5
Wirsig, K., Bürger, N., Fleischhauer, L., Preuß, N. L., & Bernhardt, A. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102154 · Cited by 5
Comprehensive review of osteoarticular tuberculosis: from epidemiology to emerging therapies
Kumari, N., Sharma, I., Kumar, D., Goel, K., Singh, V., & Katoch, S. (2025) · International Journal of Basic & Clinical Pharmacology · doi:10.18203/2319-2003.ijbcp20252594 · Cited by 6
Kang, Y., Li, M., Hu, B., Lv, Y., Du, J., Zhang, D. C., Zhou, H., & Feng, S. (2026) · Inflammation · doi:10.1007/s10753-025-02429-8 · Cited by 6
Atia, G. A. N., Ali, M. A., Abdeen, A., Alghonemy, W. Y., Elsayed, A. Z., Shaban, E., Mohammed, N. A., Mohamed, M. E., Hetta, H. F., Abass, K. S., et al. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108140 · Cited by 5
Kim, M. S., Kim, D. C., & Jo, Y. K. (2025) · Dental Materials · doi:10.1016/j.dental.2025.06.003 · Cited by 5
Li, T., Cao, S., Liao, X., Shao, Y., Zhang, L., Lü, L., Liu, Z., & Luo, X. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.855405 · Cited by 5
Yang, J., Wang, M., Yang, J., Chu, Z., Chen, X., Wu, X., & Peng, X. (2022) · Open Life Sciences · doi:10.1515/biol-2022-0503 · Cited by 5
Cao, J., Yang, B., Yarmolenka, M. A., Lian, R., Jiang, X., Zhao, J., & Rogachev, A. V. (2022) · Biomaterials Advances · doi:10.1016/j.msec.2022.112679 · Cited by 5
Cheng, L., Li, Y., Yao, Y., Jin, X., Ying, H., Xu, B., & Xu, J. (2022) · Physiological Research · doi:10.33549/physiolres.934803 · Cited by 5
Graw, C. L., Waletzko‐Hellwig, J., Saß, J., Jackszis, M., Frerich, B., Bader, R., & Dau, M. (2023) · Materials Testing · doi:10.1515/mt-2023-0004 · Cited by 5
Progress in immunoregulatory mechanisms during distraction osteogenesis
Huang, S., Zeng, A., Yin, Q., Yang, Q., Zou, B., He, M., Wang, J., & Pan, Q. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1665192 · Cited by 4
Xie, L., Zeng, J., & He, M. (2023) · BMC Cancer · doi:10.1186/s12885-023-10660-5 · Cited by 4
Li, S., Rong, Q., Zhou, Y., Che, Y., Ye, Z., Liu, J., Wang, J., & Zhou, M. (2024) · APL Bioengineering · doi:10.1063/5.0159740 · Cited by 5
Prabahar, A., Chamberlain, C. S., Vanderby, R., Murphy, W. L., Dangelo, W., Mangesh, K., Brown, B. N., Mazumder, B., Badylak, S. F., & Jiang, P. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012997 · Cited by 5
Naidu, P., Das, M., Hansda, S., Prateeksha, P., Howlader, M. S. I., Siraj, M. A., & Das, H. (2025) · ACS Omega · doi:10.1021/acsomega.4c10642 · Cited by 4
Ryu, H. S., Park, H. J., Ryu, M. Y., Kim, S.-I., Kim, S.-I., & Park, H. (2025) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-025-05966-y · Cited by 4
Ghanati, H., Motamedi, S., Fallahpour, S., Bayat, A., Maddahi, M., Kazemi, P., Aghakouchakzadeh, A., Rezaee, A., Hakimy, S., Pirouzan, M., et al. (2025) · DNA and Cell Biology · doi:10.1177/10445498251362766 · Cited by 4
Pagani, S., Salerno, M., Ločs, J., Vecstaudža, J., Dolcini, L., Fini, M., Giavaresi, G., Filardo, G., & Columbaro, M. (2025) · Journal of Functional Biomaterials · doi:10.3390/jfb16080302 · Cited by 4
Suwal, N., Jha, S. K., Thapa, R., Bashyal, S., Poudel, S., Gwachha, S., Jha, L. A., Panth, N., Idrees, S., Gupta, G., et al. (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112482 · Cited by 4
Zare, I., Far, M. S., Tajabadi, S., Jafari, Z., Heidari, B. S., Esmaeili, Y., Davachi, S. M., Mirshafiei, M., Rafienia, M., Shen, J., et al. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124200 · Cited by 4
Tjempakasari, A., Suroto, H., & Santoso, D. (2022) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2022.104796 · Cited by 4
Waletzko‐Hellwig, J., Pohl, C., Loeffler, H., Dau, M., Schlosser, M., Bader, R., & Klinder, A. (2022) · Materials & Design · doi:10.1016/j.matdes.2022.111539 · Cited by 4
Baek, D.-C., Hwang, S., Lee, J., Wang, J., Son, C., & Lee, E. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054876 · Cited by 4
Chen, Z., Encarnacion, A. M., Rajan, R. P. S., Yao, H., Lee, S., Kim, E., & Lee, T. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116335 · Cited by 4
The Categorization of Perinatal Derivatives for Orthopedic Applications
Trivedi, A. H., Wang, V. Z., McClain, E. J., Vyas, P. S., Swink, I. R., Snell, E. D., Cheng, B. C., & DeMeo, P. J. (2024) · Biomedicines · doi:10.3390/biomedicines12071544 · Cited by 4
Waletzko‐Hellwig, J., Saß, J., Bader, R., Frerich, B., & Dau, M. (2024) · Biomaterials Research · doi:10.34133/bmr.0067 · Cited by 4
Mills, E., Abbara, A., Dhillo, W. S., & Comninos, A. N. (2024) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15213 · Cited by 4
Ding, Y., Huang, Y., Zhang, F., Wang, L., Li, W., Santos, H. A., & Sun, L. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c02006 · Cited by 5
Findeisen, L., Tian, X., Vater, C., Raina, D. B., Kern, H., Bolte, J., Straßburger, L., Matuszewski, L.-M., Modler, N., Gottwald, R., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123278 · Cited by 4
Kim, J. W., Chung, D. Y., Liu, F., Huang, Y., Fridayana, F. R., Vo, M. N., Cho, K. S., Ryu, J., Kwon, M., & Yin, G. N. (2025) · The Journal of Sexual Medicine · doi:10.1093/jsxmed/qdaf091 · Cited by 4
Counteracting health risks by Modulating Homeostatic Signaling
Tian, J. J., Levy, M. A., Zhang, X., Sinnott, R., & Maddela, R. L. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106281 · Cited by 4
Halloran, D. R., Pandit, V., MacMurray, C., Stone, V., DeGeorge, K., Eskander, M. S., Root, D., McTague, S., Pelkey, H., & Nohe, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911205 · Cited by 7
Self-citationJiang, J., Röper, L., Fuchs, F., Hanschen, M., Failer, S., Alageel, S. K., Cong, X., Dornseifer, U., Schilling, A. F., Machens, H., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105315 · Cited by 4
Relevance of Cellular Redox Homeostasis for Vital Functions of Human Dental Pulp Cells
Gallorini, M., Widbiller, M., Bolay, C., Carradori, S., Buchalla, W., Cataldi, A., & Schweikl, H. (2021) · Antioxidants · doi:10.3390/antiox11010023 · Cited by 4
Saul, J. M., Bohnert, J. S., O’Brien, M., Alnuaimi, S., Carnwath, T. P., Dunivan, Q., Coffin, D. W., & Smith, T. L. (2025) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-025-00747-4 · Cited by 3
“BMP-2 has known roles in development [36], on tumorigenesis, [37] and in various body tissues [38–40].”
p75 neurotrophin receptor regulates craniofacial growth and morphology in postnatal development
Zhao, B., Suh, J., Zhang, Y., Yin, E., Kadota-Watanabe, C., Chang, I. W., Yaung, J., Lao-Ngo, I., Young, N. M., Kim, R. H., et al. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1569533 · Cited by 3
The use of molecular cues to regenerate musculoskeletal tissues
Silva, C. J. P., van Griensven, M., & Joris, V. (2025) · Innovative Surgical Sciences · doi:10.1515/iss-2025-0033 · Cited by 3
Maughan, J., Kaur, H., Prendeville, L., Carey, T., O’Connor, C., Synnatschke, K., Chávez, J. C. P., Woods, I., O’Brien, F. J., & Coleman, J. N. (2025) · Small Science · doi:10.1002/smsc.202500409 · Cited by 3
Xu, H., Settakorn, K., Khantamat, O., Li, J., Charoenphandhu, N., Chanpaisaeng, K., Paradee, N., Srichairatanakool, S., & Koonyosying, P. (2025) · npj Science of Food · doi:10.1038/s41538-025-00601-w · Cited by 4
A Novel RANKL/RANK Inhibitor IMB-R38 Inhibits Osteoporosis Through Regulating Bone Metabolism
Zhang, Y., Wei, X., Sheng, R., Yang, G., Han, X., Wang, J., Liu, C., Li, S., Lei, L., Jiang, W., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262412151 · Cited by 3
Metadata
- Authors
- Halloran, D., Durbano, H. W., & Nohe, A.
- Affiliations
- University of Delaware (US)
- Corresponding author
- Nohe, Anja
- Venue
- Journal of Developmental Biology
- Publisher
- MDPI AG
- Published
- 2020-09-13
- Volume
- 8
- Issue
- 3
- Pages
- 19
- ISSN
- 2221-3759 (ISSN-L)
- PMC
- PMC7557435
- OpenAlex
- W3085579791
- Cited by
- 348
- References
- 312
- Citations by year
- 2026: 57 · 2025: 86 · 2024: 79 · 2023: 42 · 2022: 55 · 2021: 27 · 2020: 1
- FWCI
- 2.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Developmental Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- BMP-2, BMP signaling, TGF-beta superfamily, bone homeostasis, bone remodeling, bone formation, embryonic development, digit formation, Runx2, recombinant human BMP-2, bone graft substitutes, spinal fusion, maxillary sinus reconstruction, bone disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
