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Cited by 203Osteoarthritis Treatment and MechanismsBone Tissue Engineering MaterialsTissue Engineering and Regenerative Medicine

Strategic Design and Fabrication of Engineered Scaffolds for Articular Cartilage Repair

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Izadifar, Zohreh, Chen, Xiongbiao, Kulyk, William·2012·Journal of Functional Biomaterials
DOI 10.3390/jfb3040799PMC PMC4030923
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Abstract

Damage to articular cartilage can eventually lead to osteoarthritis (OA), a debilitating, degenerative joint disease that affects millions of people around the world. The limited natural healing ability of cartilage and the limitations of currently available therapies make treatment of cartilage defects a challenging clinical issue. Hopes have been raised for the repair of articular cartilage with the help of supportive structures, called scaffolds, created through tissue engineering (TE). Over the past two decades, different designs and fabrication techniques have been investigated for developing TE scaffolds suitable for the construction of transplantable artificial cartilage tissue substitutes. Advances in fabrication technologies now enable the strategic design of scaffolds with complex, biomimetic structures and properties. In particular, scaffolds with hybrid and/or biomimetic zonal designs have recently been developed for cartilage tissue engineering applications. This paper reviews critical aspects of the design of engineered scaffolds for articular cartilage repair as well as the available advanced fabrication techniques. In addition, recent studies on the design of hybrid and zonal scaffolds for use in cartilage tissue repair are highlighted.

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Authors
Izadifar, Z., Chen, X., & Kulyk, W.
Affiliations
  • University of Saskatchewan (CA)
  • Division of Biomedical Engineering, College of Engineering, University of Saskatchewan, 57 Campus Dr., Saskatoon SK S7N5A9, Canada
ORCID
Izadifar, Zohreh
Venue
Journal of Functional Biomaterials
Publisher
MDPI AG
Published
2012-11-14
Volume
3
Issue
4
Pages
799-838
ISSN
2079-4983 (ISSN-L)
DOI
10.3390/jfb3040799
PMC
PMC4030923
OpenAlex
W2166120543
Cited by
203
References
3
Citations by year
2026: 7 · 2025: 14 · 2024: 16 · 2023: 15 · 2022: 25 · 2021: 19 · 2020: 17 · 2019: 17 · 2018: 20 · 2017: 23 · 2016: 9 · 2015: 10 · 2014: 8 · 2013: 1
FWCI
4.67
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Functional Biomaterials (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Canadian Institutes of Health Research
  • Natural Sciences and Engineering Research Council of Canada
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
articular cartilage repair, engineered scaffolds, cartilage tissue engineering, osteoarthritis, scaffold fabrication techniques, scaffold design, biomimetic scaffolds, hybrid scaffolds

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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