The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
Invasive Aspergillosis by Aspergillus flavus: Epidemiology, Diagnosis, Antifungal Resistance, and Management
Open accessAbstract
Aspergillus flavus is the second most common etiological agent of invasive aspergillosis (IA) after A. fumigatus. However, most literature describes IA in relation to A. fumigatus or together with other Aspergillus species. Certain differences exist in IA caused by A. flavus and A. fumigatus and studies on A. flavus infections are increasing. Hence, we performed a comprehensive updated review on IA due to A. flavus. A. flavus is the cause of a broad spectrum of human diseases predominantly in Asia, the Middle East, and Africa possibly due to its ability to survive better in hot and arid climatic conditions compared to other Aspergillus spp. Worldwide, ~10% of cases of bronchopulmonary aspergillosis are caused by A. flavus. Outbreaks have usually been associated with construction activities as invasive pulmonary aspergillosis in immunocompromised patients and cutaneous, subcutaneous, and mucosal forms in immunocompetent individuals. Multilocus microsatellite typing is well standardized to differentiate A. flavus isolates into different clades. A. flavus is intrinsically resistant to polyenes. In contrast to A. fumigatus, triazole resistance infrequently occurs in A. flavus and is associated with mutations in the cyp51C gene. Overexpression of efflux pumps in non-wildtype strains lacking mutations in the cyp51 gene can also lead to high voriconazole minimum inhibitory concentrations. Voriconazole remains the drug of choice for treatment, and amphotericin B should be avoided. Primary therapy with echinocandins is not the first choice but the combination with voriconazole or as monotherapy may be used when the azoles and amphotericin B are contraindicated.
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Self-citationDenning, D. W. (1998) · Clinical Infectious Diseases · doi:10.1086/513943 · Cited by 1,492
Phylogeny, identification and nomenclature of the genus Aspergillus
Samson, R. A., Visagie, C. M., Houbraken, J., Hong, S.-B., Hubka, V., Klaassen, C. H. W., Perrone, G., Seifert, K. A., Susca, A., Tanney, J. B., et al. (2014) · Studies in Mycology · doi:10.1016/j.simyco.2014.07.004 · Cited by 1,136
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Aspergillus flavus: human pathogen, allergen and mycotoxin producer
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Schauwvlieghe, A. F. A. D., Rijnders, B. J. A., Philips, N., Verwijs, R., Vanderbeke, L., Van Tienen, C., Lagrou, K., Verweij, P. E., Van de Veerdonk, F. L., Gommers, D., et al. (2018) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30274-1 · Cited by 886
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Cited by
KANO, R., TSUNOI, M., NAKAYA, Y., NAGAMINE, T., & ONO, K. (2021) · Journal of Veterinary Medical Science · doi:10.1292/jvms.20-0380 · Cited by 6
Metadata
- Authors
- Rudramurthy, S. M., Paul, R. A., Chakrabarti, A., Mouton, J. W., & Meis, J. F.
- Venue
- Journal of Fungi
- Publisher
- MDPI AG
- Published
- 2019-07-01
- Volume
- 5
- Issue
- 3
- Pages
- 55
- ISSN
- 2309-608X (ISSN-L)
- OpenAlex
- W2954335743
- Cited by
- 299
- References
- 114
- FWCI
- 19.22
- Type
- journal article
- Language
- en
- Open access
- gold
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- Rudramurthy, S. M., Paul, R. A., Chakrabarti, A., Mouton, J. W., & Meis, J. F. (2019). Invasive Aspergillosis by Aspergillus flavus: Epidemiology, Diagnosis, Antifungal Resistance, and Management. Journal of Fungi. https://doi.org/10.3390/jof5030055
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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