Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey
Open accessAbstract
Genetic medicine is one of the key components of personalized medicine, but adoption in clinical practice is still limited. To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility of genetic data as well as their preparedness to integrate it into practice. These responses were also analyzed in comparison to the type of study occurring at the physicians’ institution (pharmacogenetics versus disease genetics). The majority believed that genetic testing is clinically useful; however, only a third believed that they had obtained adequate training to care for genetically “high-risk” patients. Physicians involved in pharmacogenetics initiatives were more favorable towards genetic testing applications; they found it to be clinically useful and felt more prepared and confident in their abilities to adopt it into their practice in comparison to those participating in disease genetics initiatives. These results suggest that investigators should explore which attributes of clinical pharmacogenetics (such as the use of simplified genetics-guided recommendations) can be implemented to improve attitudes and preparedness to implement disease genetics in care. Most physicians felt unprepared to use genetic information in their practice; accordingly, major steps should be taken to develop effective clinical tools and training strategies for physicians.
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Professionals describe a lack in their own knowledge or a limited understanding of precision medicine.
“Professionals also describe a lack in their own knowledge or a limited understanding, as quantitative studies demonstrate [36, 37, 44, 81, 82, 92, 103, 104].”
From Patients’ and professionals’ views related to ethical issues in precision medicine: a mixed research synthesis (2021) · cites this paper as [81]
The majority of professionals have a positive attitude towards precision medicine in general or towards interventions labeled as precision medicine.
“Various studies reveal that the majority of professionals have a positive attitude towards PM in general or towards interventions, which are mentioned under the label of PM [27, 34, 43, 45, 47, 50, 79–83].”
From Patients’ and professionals’ views related to ethical issues in precision medicine: a mixed research synthesis (2021) · cites this paper as [81]
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Physician Experience with Direct-To-Consumer Genetic Testing in Kaiser Permanente
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Pharmacogenomic Testing In Pediatrics: Navigating The Ethical, Social, And Legal Challenges
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Long overdue: including adults with brain disorders in precision health initiatives
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Applying Pharmacogenomics to Antifungal Selection and Dosing: Are We There Yet?
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Prioritizing Pharmacogenomics Implementation Initiatives: A Survey of Healthcare Professionals
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Implementation Science to Increase Adoption of Genomic Medicine: An Urgent Need
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Clinician Experiences at the Frontier of Pharmacogenomics and Future Directions
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Engaging Pharmacogenomics in Pain Management and Opioid Selection
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Rural Community Perceptions and Interests in Pharmacogenomics
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Physicians’ Knowledge, Attitude, and Experience of Pharmacogenomic Testing in China
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Patients’ Perspectives of a Pharmacist-Provided Clinical Pharmacogenomics Service
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No person left behind: Mapping the health policy landscape for genomics research in the Caribbean
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Clinical implementation of an oncology‐specific family health history risk assessment tool
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Clinical implementation of drug metabolizing gene-based therapeutic interventions worldwide
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Perspectives from the Society for Pediatric Research: pharmacogenetics for pediatricians
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Bridging the Gap in Genomic Implementation: Identifying User Needs for Precision Nephrology
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Pharmacist Consult Reports to Support Pharmacogenomics Report Interpretation
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Role of Pharmacogenomics in Comprehensive Medication Management: Considerations for Employers
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Models of Care for the Implementation of Genetic Testing in Nephrology
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A national survey of individualized pharmaceutical care practice in Chinese hospitals in 2019
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Farmacogenômica e Doença Cardiovascular: Onde Estamos e Para Onde Vamos
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- Authors
- Owusu Obeng, A., Fei, K., Levy, K. D., Elsey, A. R., Pollin, T. I., Ramirez, A. H., Weitzel, K. W., & Horowitz, C. R.
- Affiliations
- The Charles Bronfman Institute for Personalized Medicine and Department of Genetics and Genomic Sciences, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
- Icahn School of Medicine at Mount Sinai (US)
- Indiana University Indianapolis (US)
- University of Florida Health (US)
- University of Maryland, Baltimore (US)
- Vanderbilt University (US)
- Venue
- Journal of Personalized Medicine
- Publisher
- MDPI AG
- Published
- 2018-07-24
- Volume
- 8
- Issue
- 3
- Pages
- 24
- ISSN
- 2075-4426 (ISSN-L)
- PMC
- PMC6163471
- OpenAlex
- W2884510764
- Cited by
- 131
- References
- 51
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 21 · 2023: 12 · 2022: 14 · 2021: 28 · 2020: 28 · 2019: 14 · 2018: 1
- FWCI
- 19.53
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Journal of Personalized Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- IUScholarWorks (Indiana University) (submittedVersion, cc-by-nc-nd)
- Purdue University Indianapolis (Indiana University) (submittedVersion, cc-by-nc-nd)
- Funders
- NIH/NHGRI (5U01HG007278; U01HG006380; 5U01HG007762; U01HG007775; U01HG007269; U01HG07253)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomics and Rare Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genetics, Bioinformatics, and Biomedical Research
- Keywords
- genomic medicine, clinical implementation, physician attitudes, implementation barriers, genetic testing, pharmacogenetics, disease genetics, physician preparedness, personalized medicine
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