CoChat
Sign Up
Cited by 505Plant Stress Responses and TolerancePlant biochemistry and biosynthesisPlant-Microbe Interactions and Immunity

The DOI matches its Crossref record; 208 of the 210 references it cites were found in a registry or an index.

Plant Metabolomics: An Overview of the Role of Primary and Secondary Metabolites against Different Environmental Stress Factors

Open access
Salam, Uzma, Ullah, Shakir, Tang, Zhong-Hua, Elateeq, Ahmed A., Khan, Yaseen, Khan, Jafar, Khan, Asif, Ali, Sajid·2023·Life
DOI 10.3390/life13030706PMC PMC10051737
Open this paper in CoChat — free accountOpen PDF

Abstract

Several environmental stresses, including biotic and abiotic factors, adversely affect the growth and development of crops, thereby lowering their yield. However, abiotic factors, e.g., drought, salinity, cold, heat, ultraviolet radiations (UVr), reactive oxygen species (ROS), trace metals (TM), and soil pH, are extremely destructive and decrease crop yield worldwide. It is expected that more than 50% of crop production losses are due to abiotic stresses. Moreover, these factors are responsible for physiological and biochemical changes in plants. The response of different plant species to such stresses is a complex phenomenon with individual features for several species. In addition, it has been shown that abiotic factors stimulate multi-gene responses by making modifications in the accumulation of the primary and secondary metabolites. Metabolomics is a promising way to interpret biotic and abiotic stress tolerance in plants. The study of metabolic profiling revealed different types of metabolites, e.g., amino acids, carbohydrates, phenols, polyamines, terpenes, etc, which are accumulated in plants. Among all, primary metabolites, such as amino acids, carbohydrates, lipids polyamines, and glycine betaine, are considered the major contributing factors that work as osmolytes and osmoprotectants for plants from various environmental stress factors. In contrast, plant-derived secondary metabolites, e.g., phenolics, terpenoids, and nitrogen-containing compounds (alkaloids), have no direct role in the growth and development of plants. Nevertheless, such metabolites could play a significant role as a defense by protecting plants from biotic factors such as herbivores, insects, and pathogens. In addition, they can enhance the resistance against abiotic factors. Therefore, metabolomics practices are becoming essential and influential in plants by identifying different phytochemicals that are part of the acclimation responses to various stimuli. Hence, an accurate metabolome analysis is important to understand the basics of stress physiology and biochemistry. This review provides insight into the current information related to the impact of biotic and abiotic factors on variations of various sets of metabolite levels and explores how primary and secondary metabolites help plants in response to these stresses.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3390/life13030706

Cites

208 of 208 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 Respective illustration of the processes involved in plant metabolomics analysis of GC–MS, LC-MS, CE-MS, and NMR-based chromatography.
Figure 1 Respective illustration of the processes involved in plant metabolomics analysis of GC–MS, LC-MS, CE-MS, and NMR-based chromatography.CC BY · PubMed Central
Figure 2 Environmental stresses of biotic and abiotic factors affecting the growth and homeostasis of plants.
Figure 2 Environmental stresses of biotic and abiotic factors affecting the growth and homeostasis of plants.CC BY · PubMed Central
Figure 3 Some eminent examples with medicinal properties of secondary plant metabolites are (A) salicin, (B) taxol (paclitaxel), and (C) morphine.
Figure 3 Some eminent examples with medicinal properties of secondary plant metabolites are (A) salicin, (B) taxol (paclitaxel), and (C) morphine.CC BY · PubMed Central
Figure 4 Chemical structures of some plants derived primery and scndary metabolites with key importance in different era of lfe. Among all, some commonly known alkaloids (A), cyanogenic glycosides (B), and (C) non-protein amino acids along with their protein amino acids analogues.
Figure 4 Chemical structures of some plants derived primery and scndary metabolites with key importance in different era of lfe. Among all, some commonly known alkaloids (A), cyanogenic glycosides (B), and (C) non-protein amino acids along with their protein amino acids analogues.CC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 210 references

Research works printed but not linked: 13

  1. Athar, H., and Ashraf, M. (2009). Salinity and Water Stress, Springer.
  2. Hummel, J., Strehmel, N., Bölling, C., Schmidt, S., Walther, D., and Kopka, J. (2013). The Handbook of Plant Metabolomics, Wiley.
  3. Das, 2021, Climate Change and Crop Stresses, Biot. Res. Today, 3, 351
  4. Ghag, S.B., Ganapathi, T., Jain, S.M., and Penna, S. (2022). Omics in Horticultural Crops, Elsevier.
  5. Wang, J.H., Byun, J., and Pennathur, S. (2010). Seminars in Nephrology, Elsevier.
  6. Ghatak, A., Chaturvedi, P., and Weckwerth, W. (2018). Plant Genetics and Molecular Biology, Springer.
  7. Dikilitas, M., Simsek, E., and Roychoudhury, A. (2020). Protective Chemical Agents in the Amelioration of Plant Abiotic Stress: Biochemical and Molecular Perspectives, Wiley.
  8. Krasavina, M.S., Burmistrova, N.A., and Raldugina, G.N. (2014). Emerging Technologies and Management of Crop Stress Tolerance, Elsevier.
  9. Bosila, 2016, Enhancement of callus growth and hyoscyamine alkaloid production in Hyoscyamus muticus by nanotechnology, biotic elicitor and precursor, Int. J. ChemTech. Res., 9, 135
  10. Cabane, M., Afif, D., and Hawkins, S. (2012). Advances in Botanical Research, Elsevier.
  11. Toffolatti, S.L., Maddalena, G., Passera, A., Casati, P., Bianco, P.A., and Quaglino, F. (2021). Biocontrol Agents and Secondary Metabolites, Elsevier.
  12. Al Musayeib, N.M., Musarat, A., and Maqsood, F. (2022). Eco-Friendly Biobased Products Used in Microbial Diseases, CRC Press.
  13. Davodnia, 2017, Evaluation of drought and salinity stresses on morphological and biochemical characteristics in four species of Papaver, Eco-Phytochem. J. Med. Plants, 5, 24

Cited by

Sorted by citations

Items 201–300 of 505

Related

See all

Metadata

Authors
Salam, U., Ullah, S., Tang, Z.-H., Elateeq, A. A., Khan, Y., Khan, J., Khan, A., & Ali, S.
Affiliations
  • Northeast Forestry University (CN)
  • Key Laboratory of Plant Ecology, Northeast Forestry Universit y, Harbin 150040, China
  • Al-Azhar University (EG)
  • Northwest A&F University (CN)
  • Universidade de São Paulo (BR)
  • Yeungnam University (KR)
Corresponding author
Ali, Sajid
ORCID
Venue
Life
Publisher
MDPI AG
Published
2023-03-06
Volume
13
Issue
3
Pages
706
ISSN
2075-1729 (ISSN-L)
DOI
10.3390/life13030706
PMC
PMC10051737
OpenAlex
W4323313289
Cited by
480
References
210
Citations by year
2026: 165 · 2025: 192 · 2024: 104 · 2023: 19
FWCI
11.50
Type
journal article
Language
en
Open access
Licence
Locations
  • Life (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
The key Research and Development project of Heilongjiang Province, China (JD22A008)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
Keywords
plant metabolomics, primary metabolites, secondary metabolites, abiotic stress, biotic stress, drought stress, salt stress, cold stress, heat stress, ultraviolet radiation, reactive oxygen species, trace metals, soil pH, osmolytes, betaine, polyamines, phenolic compounds, terpenoids, alkaloids, plant stress tolerance, crop yield loss

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review