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Cited by 505Plant Stress Responses and TolerancePlant biochemistry and biosynthesisPlant-Microbe Interactions and Immunity

The DOI matches its Crossref record; 208 of the 210 references it cites were found in a registry or an index.

Plant Metabolomics: An Overview of the Role of Primary and Secondary Metabolites against Different Environmental Stress Factors

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Salam, Uzma, Ullah, Shakir, Tang, Zhong-Hua, Elateeq, Ahmed A., Khan, Yaseen, Khan, Jafar, Khan, Asif, Ali, Sajid·2023·Life
DOI 10.3390/life13030706PMC PMC10051737
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Abstract

Several environmental stresses, including biotic and abiotic factors, adversely affect the growth and development of crops, thereby lowering their yield. However, abiotic factors, e.g., drought, salinity, cold, heat, ultraviolet radiations (UVr), reactive oxygen species (ROS), trace metals (TM), and soil pH, are extremely destructive and decrease crop yield worldwide. It is expected that more than 50% of crop production losses are due to abiotic stresses. Moreover, these factors are responsible for physiological and biochemical changes in plants. The response of different plant species to such stresses is a complex phenomenon with individual features for several species. In addition, it has been shown that abiotic factors stimulate multi-gene responses by making modifications in the accumulation of the primary and secondary metabolites. Metabolomics is a promising way to interpret biotic and abiotic stress tolerance in plants. The study of metabolic profiling revealed different types of metabolites, e.g., amino acids, carbohydrates, phenols, polyamines, terpenes, etc, which are accumulated in plants. Among all, primary metabolites, such as amino acids, carbohydrates, lipids polyamines, and glycine betaine, are considered the major contributing factors that work as osmolytes and osmoprotectants for plants from various environmental stress factors. In contrast, plant-derived secondary metabolites, e.g., phenolics, terpenoids, and nitrogen-containing compounds (alkaloids), have no direct role in the growth and development of plants. Nevertheless, such metabolites could play a significant role as a defense by protecting plants from biotic factors such as herbivores, insects, and pathogens. In addition, they can enhance the resistance against abiotic factors. Therefore, metabolomics practices are becoming essential and influential in plants by identifying different phytochemicals that are part of the acclimation responses to various stimuli. Hence, an accurate metabolome analysis is important to understand the basics of stress physiology and biochemistry. This review provides insight into the current information related to the impact of biotic and abiotic factors on variations of various sets of metabolite levels and explores how primary and secondary metabolites help plants in response to these stresses.

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Crossref · 10.3390/life13030706

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Figures

Figure 1 Respective illustration of the processes involved in plant metabolomics analysis of GC–MS, LC-MS, CE-MS, and NMR-based chromatography.
Figure 1 Respective illustration of the processes involved in plant metabolomics analysis of GC–MS, LC-MS, CE-MS, and NMR-based chromatography.CC BY · PubMed Central
Figure 2 Environmental stresses of biotic and abiotic factors affecting the growth and homeostasis of plants.
Figure 2 Environmental stresses of biotic and abiotic factors affecting the growth and homeostasis of plants.CC BY · PubMed Central
Figure 3 Some eminent examples with medicinal properties of secondary plant metabolites are (A) salicin, (B) taxol (paclitaxel), and (C) morphine.
Figure 3 Some eminent examples with medicinal properties of secondary plant metabolites are (A) salicin, (B) taxol (paclitaxel), and (C) morphine.CC BY · PubMed Central
Figure 4 Chemical structures of some plants derived primery and scndary metabolites with key importance in different era of lfe. Among all, some commonly known alkaloids (A), cyanogenic glycosides (B), and (C) non-protein amino acids along with their protein amino acids analogues.
Figure 4 Chemical structures of some plants derived primery and scndary metabolites with key importance in different era of lfe. Among all, some commonly known alkaloids (A), cyanogenic glycosides (B), and (C) non-protein amino acids along with their protein amino acids analogues.CC BY · PubMed Central

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Citations

Cites

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Metadata

Authors
Salam, U., Ullah, S., Tang, Z.-H., Elateeq, A. A., Khan, Y., Khan, J., Khan, A., & Ali, S.
Affiliations
  • Northeast Forestry University (CN)
  • Key Laboratory of Plant Ecology, Northeast Forestry Universit y, Harbin 150040, China
  • Al-Azhar University (EG)
  • Northwest A&F University (CN)
  • Universidade de São Paulo (BR)
  • Yeungnam University (KR)
Corresponding author
Ali, Sajid
ORCID
Venue
Life
Publisher
MDPI AG
Published
2023-03-06
Volume
13
Issue
3
Pages
706
ISSN
2075-1729 (ISSN-L)
DOI
10.3390/life13030706
PMC
PMC10051737
OpenAlex
W4323313289
Cited by
480
References
210
Citations by year
2026: 165 · 2025: 192 · 2024: 104 · 2023: 19
FWCI
11.50
Type
journal article
Language
en
Open access
Licence
Locations
  • Life (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
The key Research and Development project of Heilongjiang Province, China (JD22A008)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
Keywords
plant metabolomics, primary metabolites, secondary metabolites, abiotic stress, biotic stress, drought stress, salt stress, cold stress, heat stress, ultraviolet radiation, reactive oxygen species, trace metals, soil pH, osmolytes, betaine, polyamines, phenolic compounds, terpenoids, alkaloids, plant stress tolerance, crop yield loss

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