The DOI matches its Crossref record; 418 of the 418 references it cites were found in a registry or an index.
Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications
Open accessAbstract
The gastrointestinal tract is home to trillions of diverse microorganisms collectively known as the gut microbiota, which play a pivotal role in breaking down undigested foods, such as dietary fibers. Through the fermentation of these food components, short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate are produced, offering numerous health benefits to the host. The production and absorption of these SCFAs occur through various mechanisms within the human intestine, contingent upon the types of dietary fibers reaching the gut and the specific microorganisms engaged in fermentation. Medical literature extensively documents the supplementation of SCFAs, particularly butyrate, in the treatment of gastrointestinal, metabolic, cardiovascular, and gut-brain-related disorders. This review seeks to provide an overview of the dynamics involved in the production and absorption of acetate, propionate, and butyrate within the human gut. Additionally, it will focus on the pivotal roles these SCFAs play in promoting gastrointestinal and metabolic health, as well as their current therapeutic implications.
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1 retracted
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KEGG as a reference resource for gene and protein annotation
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Gut microbiota in human metabolic health and disease
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Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
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Background
Cited by
Aslam, H., Trakman, G., Dissanayake, T., Todd, E., Harrison, P., Alby, C., Jabeen, T., Gamage, E., Travica, N., Marshall, S., et al. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-025-07428-9 · Cited by 30
Buchynskyi, M., Kamyshna, I., Halabitska, I., Petakh, P., Kunduzova, O., Oksenych, V., & Kamyshnyi, O. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1577724 · Cited by 30
Microbiome−mediated crosstalk between T2DM and MASLD: a translational review focused on function
Jing, M., & Jiang, Y. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1677175 · Cited by 24
Metadata
- Authors
- Facchin, S., Bertin, L., Bonazzi, E., Lorenzon, G., De Barba, C., Barberio, B., Zingone, F., Maniero, D., Scarpa, M., Ruffolo, C., Angriman, I., & Savarino, E. V.
- Venue
- Life
- Publisher
- MDPI AG
- Published
- 2024-04-26
- Volume
- 14
- Issue
- 5
- Pages
- 559
- ISSN
- 2075-1729 (ISSN-L)
- OpenAlex
- W4395676073
- Cited by
- 380
- References
- 418
- FWCI
- 43.92
- Type
- journal article
- Language
- en
- Open access
- gold
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- Facchin, S., Bertin, L., Bonazzi, E., Lorenzon, G., De Barba, C., Barberio, B., Zingone, F., Maniero, D., Scarpa, M., Ruffolo, C., Angriman, I., & Savarino, E. V. (2024). Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications. Life. https://doi.org/10.3390/life14050559
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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