The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Eudragit S100 Coated Citrus Pectin Nanoparticles for Colon Targeting of 5-Fluorouracil
Open accessAbstract
In the present study, Eudragit S100 coated Citrus Pectin Nanoparticles (E-CPNs) were prepared for the colon targeting of 5-Fluorouracil (5-FU). Citrus pectin also acts as a ligand for galectin-3 receptors that are over expressed on colorectal cancer cells. Nanoparticles (CPNs and E-CPNs) were characterized for various physical parameters such as particle size, size distribution, and shape etc. In vitro drug release studies revealed selective drug release in the colonic region in the case of E-CPNs of more than 70% after 24 h. In vitro cytoxicity assay (Sulphorhodamine B assay) was performed against HT-29 cancer cells and exhibited 1.5 fold greater cytotoxicity potential of nanoparticles compared to 5-FU solution. In vivo data clearly depicted that Eudragit S100 successfully guarded nanoparticles to reach the colonic region wherein nanoparticles were taken up and showed drug release for an extended period of time. Therefore, a multifaceted strategy is introduced here in terms of receptor mediated uptake and pH-dependent release using E-CPNs for effective chemotherapy of colorectal cancer with uncompromised safety and efficacy.
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Jain, A., Jain, S. K., Ganesh, N., Barve, J., & Beg, A. M. (2010) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2009.03.002 · Cited by 214
Self-citationAnti-cancer activities of pH- or heat-modified pectin
Leclere, L., Cutsem, P. V., & Michiels, C. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00128 · Cited by 203
Cited by
The Smart Drug Delivery System and Its Clinical Potential
Liu, D., Yang, F., Xiong, F., & Gu, N. (2016) · Theranostics · doi:10.7150/thno.14858 · Cited by 1,066
El-Sawy, H. S., Al-Abd, A. M., Ahmed, T. A., El-Say, K. M., & Torchilin, V. P. (2018) · ACS Nano · doi:10.1021/acsnano.8b06104 · Cited by 431
Nano drug delivery strategy of 5-fluorouracil for the treatment of colorectal cancer
Chandran, S. P., Natarajan, S. B., Chandraseharan, S., & Mohd Shahimi, M. S. B. (2017) · Journal of Cancer Research and Practice · doi:10.1016/j.jcrpr.2017.02.002 · Cited by 97
Metadata
- Authors
- Subudhi, M., Jain, A., Jain, A., Hurkat, P., Shilpi, S., Gulbake, A., & Jain, S.
- Venue
- Materials
- Publisher
- MDPI AG
- Published
- 2015-02-27
- Volume
- 8
- Issue
- 3
- Pages
- 832-849
- ISSN
- 1996-1944 (ISSN-L)
- OpenAlex
- W2049115012
- Cited by
- 164
- References
- 2
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- gold
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- Subudhi, M., Jain, A., Jain, A., Hurkat, P., Shilpi, S., Gulbake, A., & Jain, S. (2015). Eudragit S100 Coated Citrus Pectin Nanoparticles for Colon Targeting of 5-Fluorouracil. Materials. https://doi.org/10.3390/ma8030832
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