The DOI matches its Crossref record; 379 of the 379 references it cites were found in a registry or an index.
Bioactive Compounds Isolated from Microalgae in Chronic Inflammation and Cancer
Open accessAbstract
The risk of onset of cancer is influenced by poorly controlled chronic inflammatory processes. Inflammatory diseases related to cancer development include inflammatory bowel disease, which can lead to colon cancer, or actinic keratosis, associated with chronic exposure to ultraviolet light, which can progress to squamous cell carcinoma. Chronic inflammatory states expose these patients to a number of signals with tumorigenic effects, including nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPK) activation, pro-inflammatory cytokines and prostaglandins release and ROS production. In addition, the participation of inflammasomes, autophagy and sirtuins has been demonstrated in pathological processes such as inflammation and cancer. Chemoprevention consists in the use of drugs, vitamins, or nutritional supplements to reduce the risk of developing or having a recurrence of cancer. Numerous in vitro and animal studies have established the potential colon and skin cancer chemopreventive properties of substances from marine environment, including microalgae species and their products (carotenoids, fatty acids, glycolipids, polysaccharides and proteins). This review summarizes the main mechanisms of actions of these compounds in the chemoprevention of these cancers. These actions include suppression of cell proliferation, induction of apoptosis, stimulation of antimetastatic and antiangiogenic responses and increased antioxidant and anti-inflammatory activity.
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1 retracted
Hayashi (1996) · doi:10.1016/j.intimp.2005.09.009 · Cited by 60
RetractedCoussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Nuclear factor-κB in cancer development and progression
Karin, M. (2006) · Nature · doi:10.1038/nature04870 · Cited by 3,519
Cancer treatment and survivorship statistics, 2014
DeSantis, C. E., Lin, C. C., Mariotto, A. B., Siegel, R. L., Stein, K. D., Kramer, J. L., Alteri, R., Robbins, A. S., & Jemal, A. (2014) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21235 · Cited by 2,779
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S.-I., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,659
Autophagy in Human Health and Disease
Choi, A. M. K., Ryter, S. W., & Levine, B. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1205406 · Cited by 2,583
Mammalian Sirtuins: Biological Insights and Disease Relevance
Haigis, M. C., & Sinclair, D. A. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092250 · Cited by 2,085
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Microalgae for High-Value Products Towards Human Health and Nutrition
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Blunt, J. W., Copp, B. R., Keyzers, R. A., Munro, M. H. G., & Prinsep, M. R. (2017) · Natural Product Reports · doi:10.1039/c6np00124f · Cited by 465
Microalgae in modern cancer therapy: current knowledge
Abd El-Hack, M. E., Abdelnour, S., Alagawany, M., Abdo, M., Sakr, M. A., Khafaga, A. F., Mahgoub, S. A., Elnesr, S. S., & Gebriel, M. G. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.069 · Cited by 206
Spínola, M. P., Mendes, A. R., & Prates, J. A. M. (2024) · Foods · doi:10.3390/foods13223656 · Cited by 146
Rajasekar, P., Palanisamy, S., Anjali, R., Vinosha, M., Elakkiya, M., Marudhupandi, T., Tabarsa, M., You, S., & Prabhu, N. M. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.09.024 · Cited by 126
Metadata
- Authors
- Talero, E., García-Mauriño, S., Ávila-Román, J., Rodríguez-Luna, A., Alcaide, A., & Motilva, V.
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2015-09-30
- Volume
- 13
- Issue
- 10
- Pages
- 6152-6209
- ISSN
- 1660-3397 (ISSN-L)
- OpenAlex
- W2155167868
- Cited by
- 255
- References
- 379
- FWCI
- 21.88
- Type
- journal article
- Language
- en
- Open access
- gold
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- Talero, E., García-Mauriño, S., Ávila-Román, J., Rodríguez-Luna, A., Alcaide, A., & Motilva, V. (2015). Bioactive Compounds Isolated from Microalgae in Chronic Inflammation and Cancer. Marine Drugs. https://doi.org/10.3390/md13106152
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
