Structural Characteristics and Anticoagulant Property In Vitro and In Vivo of a Seaweed Sulfated Rhamnan
Open accessAbstract
Great diversity and metabolite complexity of seaweeds offer a unique and exclusive source of renewable drug molecules. Polysaccharide from seaweed has potential as a promising candidate for marine drug development. In the present study, seaweed polysaccharide (SPm) was isolated from Monostroma angicava, the polymeric repeat units and anticoagulant property in vitro and in vivo of SPm were investigated. SPm was a sulfated polysaccharide which was mainly constituted by 3-linked, 2-linked-α-l-rhamnose residues with partially sulfate groups at C-2 of 3-linked α-l-rhamnose residues and C-3 of 2-linked α-l-rhamnose residues. Small amounts of xylose and glucuronic acid exist in the forms of β-d-Xylp(4SO4)-(1→ and β-d-GlcA-(1→. SPm effectively prolonged clotting time as evaluated by the activated partial thromboplastin time and thrombin time assays, and exhibited strong anticoagulant activity in vitro and in vivo. The fibrin(ogen)olytic and thrombolytic properties of SPm were evaluated by plasminogen activator inhibitior-1, fibrin degradation products, D-dimer and clot lytic rate assays using rats plasma, and the results showed that SPm possessed high fibrin(ogen)olytic and thrombolytic properties. These results suggested that SPm has potential as a novel anticoagulant agent.
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Phlorotannins and sulfated polysaccharides such as fucoidans in brown algae, carrageenans in red algae, and ulvans in green algae have been recognized as potential anticoagulant agents.
“Phlorotannins and sulfated polysaccharides such as fucoidans in brown algae, carrageenans in red algae, and ulvans in green algae have been recognized as potential anticoagulant agents [61,62,63,64].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [61]
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- Authors
- Liu, X., Wang, S., Cao, S., He, X., Qin, L., He, M., Yang, Y., Hao, J., & Mao, W.
- Affiliations
- Qilu University of Technology (CN)
- Ocean University of China (CN)
- Qingdao National Laboratory for Marine Science and Technology (CN)
- Corresponding author
- Mao, Wenjun
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2018-07-20
- Volume
- 16
- Issue
- 7
- Pages
- 243
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC6070894
- OpenAlex
- W2884986852
- Cited by
- 63
- References
- 52
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 5 · 2023: 13 · 2022: 9 · 2021: 10 · 2020: 7 · 2019: 7 · 2018: 1
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (41476108)
- NSFC-Shandong Joint Fund for Marine Science Research Centers (U1606403)
- Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology (2016ASKJ02 and 2015ASKJ02)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Keywords
- seaweed polysaccharides, anticoagulant activity, polysaccharide structure, fibrinolytic activity, thrombolytic activity, D-dimer, activated partial thromboplastin time, thrombin time
- MeSH terms
- Chlorophyta, Animals, Anticoagulants, Deoxy Sugars, Fibrinolytic Agents, Male, Mannans, Partial Thromboplastin Time, Polysaccharides, Seaweed, Sulfates, Thrombin Time, Thrombosis, Rats, Sprague-Dawley, Plasminogen Activator Inhibitor 1, Rats
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