The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Recent Advances in Chitosan-Based Carriers for Gene Delivery
Open accessAbstract
Approximately 4000 diseases are associated with malfunctioning genes in a particular cell type. Gene-based therapy provides a platform to modify the disease-causing genes expression at the cellular level to treat pathological conditions. However, gene delivery is challenging as these therapeutic genes need to overcome several physiological and intracellular barriers in order, to reach the target cells. Over the years, efforts have been dedicated to develop efficient gene delivery vectors to overcome these systemic barriers. Chitosan, a versatile polysaccharide, is an attractive non-viral vector material for gene delivery mainly due to its cationic nature, biodegradability and biocompatibility. The present review discusses the design factors that are critical for efficient gene delivery/transfection and highlights the recent progress of gene therapy using chitosan-based carriers.
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Cites
Non-viral vectors for gene-based therapy
Yin, H., Kanasty, R. L., Eltoukhy, A. A., Vegas, A. J., Dorkin, J. R., & Anderson, D. G. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3763 · Cited by 3,123
Design and development of polymers for gene delivery
Pack, D. W., Hoffman, A. S., Pun, S., & Stayton, P. S. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1775 · Cited by 2,568
Gene therapy clinical trials worldwide to 2017: An update
Ginn, S. L., Amaya, A. K., Alexander, I. E., Edelstein, M., & Abedi, M. R. (2018) · The Journal of Gene Medicine · doi:10.1002/jgm.3015 · Cited by 903
Li, W. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2003.10.041 · Cited by 588
Cited by
Harugade, A., Sherje, A. P., & Pethe, A. (2023) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2023.105634 · Cited by 474
Chitosan Nanoparticles at the Biological Interface: Implications for Drug Delivery
Aibani, N., Rai, R., Patel, P., Cuddihy, G., & Wasan, E. K. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101686 · Cited by 419
The Importance of Apparent pKa in the Development of Nanoparticles Encapsulating siRNA and mRNA
Patel, P., Ibrahim, N. M., & Cheng, K. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.03.002 · Cited by 280
Metadata
- Authors
- Cao, Y., Tan, Y. F., Wong, Y. S., Liew, M. W. J., & Venkatraman, S.
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2019-06-25
- Volume
- 17
- Issue
- 6
- Pages
- 381
- ISSN
- 1660-3397 (ISSN-L)
- OpenAlex
- W2954838189
- Cited by
- 361
- References
- 4
- FWCI
- 12.25
- Type
- journal article
- Language
- en
- Open access
- gold
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- Cao, Y., Tan, Y. F., Wong, Y. S., Liew, M. W. J., & Venkatraman, S. (2019). Recent Advances in Chitosan-Based Carriers for Gene Delivery. Marine Drugs. https://doi.org/10.3390/md17060381
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