The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
The Importance of Apparent pKa in the Development of Nanoparticles Encapsulating siRNA and mRNA
Open accessAbstract
Polymer and lipid nanoparticles have been extensively used as carriers to address the biological barriers encountered in siRNA and mRNA delivery. In this review, we summarize the critical role of nanoparticle’s charges and ionizability in complexing RNAs, binding biological components, escaping from the endosome, and releasing RNAs to the cytoplasm. We highlight the significant impact of the apparent pKa of nanoparticles on the efficacy and toxicity of the nanoparticles and the importance of optimizing pKa in the development of lead formulations for RNAs. Also, we discuss the feasibility of fine-tuning of pKa in nanoparticles and the applications of using this approach in the optimization of delivery systems for RNAs.
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Cites
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Cited by
Effect of mRNA-LNP components of two globally-marketed COVID-19 vaccines on efficacy and stability
Zhang, L., More, K. R., Ojha, A., Jackson, C. B., Quinlan, B. D., Li, H., He, W., Farzan, M., Pardi, N., & Choe, H. (2023) · npj Vaccines · doi:10.1038/s41541-023-00751-6 · Cited by 244
pH-Responsive polymer boosts cytosolic siRNA release for retinal neovascularization therapy
Guo, S., Li, C., Wang, C., Cao, X., Liu, X., Liang, X.-J., Huang, Y., & Weng, Y. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.09.001 · Cited by 36
Metadata
- Authors
- Patel, P., Ibrahim, N. M., & Cheng, K.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 42
- Issue
- 6
- Pages
- 448-460
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W3153698244
- Cited by
- 280
- References
- 86
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Patel, P., Ibrahim, N. M., & Cheng, K. (2021). The Importance of Apparent pKa in the Development of Nanoparticles Encapsulating siRNA and mRNA. Trends in Pharmacological Sciences. https://doi.org/10.1016/j.tips.2021.03.002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
