Chitosan Oleate Coated Poly Lactic-Glycolic Acid (PLGA) nanoparticles versus chitosan oleate self-assembled polymeric micelles, loaded with resveratrol.
Open accessAbstract
Chitosan oleate (CS-OA), a chitosan salt with amphiphilic properties, has demonstrated the ability to self-assemble in aqueous environment to give polymeric micelles useful to load poorly soluble drugs. More recently, CS-OA was proposed to stabilize nanoemulsions during the preparation by emulsification and solvent evaporation of poly lactic-glycolic acid (PLGA) nanoparticles (NPs) loaded with curcumin. Positive mucoadhesive behavior and internalization properties were demonstrated for these NPs attributable to the presence of positive charge at the NP surface. In the present paper, two CS-OA-based nanosystems, micelles and PLGA NPs, were compared with the aim of elucidating their physico-chemical characteristics, and especially their interaction with cell substrates. The two systems were loaded with resveratrol (RSV), a hydrophobic polyphenol endowed with anti-cancerogenic, anti-inflammatory, and heart/brain protective effects, but with low bioavailability mainly due to poor aqueous solubility. Calorimetric analysis and X-ray spectra demonstrated amorphization of RSV, confirming its affinity for hydrophobic domains of polymeric micelles and PLGA core of NPs. TGA decomposition patterns suggest higher stability of PLGA-NPs compared with polymeric micelles, that anyway resulted more stable than expected, considering the RSV release profiles, and the cell line interaction results.
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PLGA nanoparticles coated with Chitosan oleate (CS-OA) were found to be more stable compared with polymeric micelles based on release profiles, TGA analysis, and cell line interaction results.
“micelles and PLGA NPs, loaded with lipophillic model drug i.e., resveratrol, based on release profiles, TGA analysis and the cell line interaction results PLGA-CS-OA found to be more stable compared with polymeric micelles (Miele et al., 2019).”
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Cites
Biodegradation and biocompatibility of PLA and PLGA microspheres
Anderson, J. M., & Shive, M. S. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00048-3 · Cited by 2,617 · see citing works
He, C., Hu, Y., Yin, L., Tang, C., & Yin, C. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.065 · Cited by 2,607 · see citing works
Biodegradation and biocompatibility of PLA and PLGA microspheres
Anderson, J., & Shive, M. S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.004 · Cited by 814 · see citing works
Hühn, D., Kantner, K., Geidel, C., Brandholt, S., Cock, I. D., Soenen, S. J., Rivera-Gil, P., Montenegro, J., Braeckmans, K., Müllen, K., et al. (2013) · ACS Nano · doi:10.1021/nn3059295 · Cited by 582 · see citing works
N-acylated chitosan: hydrophobic matrices for controlled drug release
Tien, C. L., Lacroix, M., Ispas‐Szabo, P., & Mateescu, M. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00327-4 · Cited by 332 · see citing works
Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies
Mileo, A. M., & Miccadei, S. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6475624 · Cited by 291 · see citing works
Chitosan Amphiphilic Derivatives. Chemistry and Applications
Aranaz, I., Harris, R., & Heras, Á. (2010) · Current Organic Chemistry · doi:10.2174/138527210790231919 · Cited by 273 · see citing works
Xing, K., Chen, X. G., Kong, M., Liu, C. S., Cha, D. S., & Park, H. J. (2009) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2008.09.016 · Cited by 174 · see citing works
Resveratrol Brain Delivery for Neurological Disorders Prevention and Treatment
Andrade, S., Ramalho, M. J., Pereira, M. D. C., & Loureiro, J. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01261 · Cited by 173 · see citing works
Novel Polymer Micelles Prepared from Chitosan Grafted Hydrophobic Palmitoyl Groups for Drug Delivery
Jiang, G., Quan, D., Liao, K., & Wang, H. (2006) · Molecular Pharmaceutics · doi:10.1021/mp050010c · Cited by 163 · see citing works
Colloidal mesoporous silica nanoparticles enhance the biological activity of resveratrol
Summerlin, N., Qu, Z., Pujara, N., Sheng, Y., Jambhrunkar, S., McGuckin, M. A., & Popat, A. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.03.076 · Cited by 146 · see citing works
Paiva‐Santos, A. C., Pereira, I., Pereira‐Silva, M., Ferreira, L., Caldas, M., Collado-González, M., Magalhães, M., Figueiras, A., Ribeiro, A. J., & Veiga, F. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.04.030 · Cited by 121 · see citing works
Motiei, M., Kashanian, S., Lucia, L. A., & Khazaei, M. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.06.010 · Cited by 107 · see citing works
Nutakul, W., Sobers, H. S., Qiu, P., Dong, P., Decker, E. A., McClements, D. J., & Xiao, H. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf202846b · Cited by 102 · see citing works
Bonferoni, M. C., Sandri, G., Dellera, E., Rossi, S., Ferrari, F., Mori, M., & Caramella, C. M. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2013.12.018 · Cited by 96 · see citing works
Self-citationDellera, E., Bonferoni, M. C., Sandri, G., Rossi, S., Ferrari, F., Fante, C. D., Perotti, C. G., Grisoli, P., & Caramella, C. M. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.07.015 · Cited by 95 · see citing works
Self-citationBonferoni, M. C., Rossi, S., Sandri, G., & Ferrari, F. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.06.010 · Cited by 92 · see citing works
Self-citationGlaser, T. K., Plohl, O., Vesel, A., Ajdnik, U., Ulrih, N. P., Hrnčič, M. K., Bren, U., & Zemljič, L. F. (2019) · Materials · doi:10.3390/ma12132118 · Cited by 84 · see citing works
Precise derivatization of structurally distinct chitosans with rhodamine B isothiocyanate
Ma, O., Lavertu, M., Sun, J., Nguyen, S., Buschmann, M. D., Winnik, F. M., & Hoemann, C. D. (2007) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2007.10.004 · Cited by 73 · see citing works
Novel amphiphilic chitosan nanocarriers for sustained oral delivery of hydrophobic drugs
Motiei, M., & Kashanian, S. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.12.035 · Cited by 72 · see citing works
Resveratrol and inflammatory bowel disease
Shi, Y., Zhou, J., Jiang, B., & Miao, M. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13426 · Cited by 72 · see citing works
Bonferoni, M. C., Sandri, G., Rossi, S., Usai, D., Liakos, I., Garzoni, A., Fiamma, M., Zanetti, S., Athanassiou, A., Caramella, C., et al. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.01.043 · Cited by 67 · see citing works
Self-citationConti, B., Bucolo, C., Giannavola, C., Puglisi, G., Giunchedi, P., & Conte, U. (1997) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(97)00023-7 · Cited by 61 · see citing works
Rose, F., Wern, J. E., Gavins, F. K. H., Andersen, P. L., Follmann, F., & Foged, C. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.12.003 · Cited by 57 · see citing works
Mahmoudzadeh, M., Fassihi, A., Emami, J., Davies, N. M., & Dorkoosh, F. A. (2013) · Journal of drug targeting · doi:10.3109/1061186x.2013.824455 · Cited by 41 · see citing works
Palmitoyl Glycol Chitosan Micelles for Corneal Delivery of Cyclosporine
Bonferoni, M. C., Sandri, G., Dellera, E., Rossi, S., Ferrari, F., Zambito, Y., & Caramella, C. M. (2015) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2016.2140 · Cited by 30 · see citing works
Self-citationMonika, B. S. P., Garg, R., & Sardana, S. (2016) · Current Drug Delivery · doi:10.2174/1567201814666161109115735 · Cited by 13 · see citing works
Miele, D., Rossi, S., Sandri, G., Vigani, B., Sorrenti, M., Giunchedi, P., Ferrari, F., & Bonferoni, M. C. (2018) · Marine Drugs · doi:10.3390/md16110447 · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Polymeric micelles in cancer therapy: State of the art
Ghosh, B., & Biswas, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.016 · Cited by 553 · see citing works
Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs
Naqvi, S., Panghal, A., & Flora, S. J. S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00494 · Cited by 305 · see citing works
“, resveratrol, based on release profiles, TGA analysis and the cell line interaction results PLGA-CS-OA found to be more stable compared with polymeric micelles (Miele et al., 2019).”
BackgroundNanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols
Yang, B., Dong, Y., Wang, F., & Zhang, Y. (2020) · Molecules · doi:10.3390/molecules25204613 · Cited by 280 · see citing works
Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix
Detsi, A., Kavetsou, E., Kostopoulou, I., Pitterou, I., Pontillo, A. R. N., Tzani, A., Christodoulou, P., Siliachli, A., & Zoumpoulakis, P. G. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12070669 · Cited by 201 · see citing works
Ghazi, R., Ibrahim, T. K., Nasir, J. A., Gai, S., Ali, G., Boukhris, I., & Rehman, Z. (2025) · RSC Advances · doi:10.1039/d5ra00728c · Cited by 121 · see citing works
Aldawsari, H. M., Alhakamy, N. A., Padder, R. A., Husain, M., & Md, S. (2020) · Coatings · doi:10.3390/coatings10050439 · Cited by 86 · see citing works
Neuro-nanotechnology: diagnostic and therapeutic nano-based strategies in applied neuroscience
Shabani, L., Abbasi, M., Azarnew, Z., Amani, A. M., & Vaez, A. (2023) · BioMedical Engineering OnLine · doi:10.1186/s12938-022-01062-y · Cited by 80 · see citing works
Wu, Z., Li, H., Zhao, X., Ye, F., & Zhao, G. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119182 · Cited by 73 · see citing works
Rhaman, M. M., Islam, M. R., Akash, S., Mim, M., Noor alam, M., Nepovimova, E., Valis, M., Kuca, K., & Sharma, R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.989471 · Cited by 63 · see citing works
Comincini, S., Manai, F., Sorrenti, M., Perteghella, S., D’Amato, C., Miele, D., Catenacci, L., & Bonferoni, M. C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041078 · Cited by 33 · see citing works
Self-citationAdapted nano-carriers for gastrointestinal defense components: surface strategies and challenges
Wang, W., Yan, X., Li, Q., Chen, Z., Wang, Z., & Hu, H. (2020) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2020.102277 · Cited by 30 · see citing works
Assessment of Residual Solvent and Drug in PLGA Microspheres by Derivative Thermogravimetry
Shim, H., & Sah, H. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12070626 · Cited by 29 · see citing works
Chang, P.-K., Tsai, M., Huang, C.-Y., Lee, C., Lin, C., Shieh, C., & Kuo, C. (2021) · Marine Drugs · doi:10.3390/md19080470 · Cited by 24 · see citing works
Chitosan Oleate Coated PLGA Nanoparticles as siRNA Drug Delivery System
Miele, D., Xia, X., Catenacci, L., Sorrenti, M., Rossi, S., Sandri, G., Ferrari, F., Rossi, J. J., & Bonferoni, M. C. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101716 · Cited by 21 · see citing works
Self-citationMiele, D., Sorrenti, M., Catenacci, L., Minzioni, P., Marrubini, G., Amendola, V., Maestri, M., Giunchedi, P., & Bonferoni, M. C. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14081740 · Cited by 18 · see citing works
Self-citationFeng, Y., Fan, J., Wu, D., Liu, Q., Li, H., Zhang, X., Li, S., Tang, F. R., Liu, Z., Zhang, L., et al. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.12.158 · Cited by 15 · see citing works
Nanoparticle-Based Drug Delivery System—A Target Strategy for Osteoarthritis Treatment
Liu, K., Zhang, D., & Wang, W. (2021) · Journal of Nanomaterials · doi:10.1155/2021/4064983 · Cited by 12 · see citing works
Collagen/PCL electrospun fibers loaded with polyphenols: Curcumin and resveratrol comparison
Miele, D., Catenacci, L., Sorrenti, M., Perteghella, S., Filiberti, S., Mandracchia, D., Ronca, R., & Bonferoni, M. C. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135333 · Cited by 10 · see citing works
Self-citationDrug Polymeric Carrier of Aceclofenac Based on Amphiphilic Chitosan Micelles
Alenazi, N. A., Bokhari, M. G., Abourehab, M. A. S., & Abukhadra, M. R. (2023) · ACS Omega · doi:10.1021/acsomega.3c07065 · Cited by 7 · see citing works
Nanomaterials in bioprocessing and their biomedical applications
Padma, S., Dey, S., Banerjee, M., Modak, B. K., & Mukherjee, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91782-7.00011-4 · Cited by 3 · see citing works
Zufry, H., Rudijanto, A., Soeatmadji, D. W., Sakti, S. P., Munadi, K., Sujuti, H., & Mintaroem, K. (2024) · F1000Research · doi:10.12688/f1000research.128740.1 · Cited by 3 · see citing works
[A photothermal/chemotherapy injectable paclitaxel gel with irradiation stability].
Ouyang, Y., Zhang, K., Zhou, L., Chen, Y., & Luo, X. (2021) · PubMed Central · doi:10.7507/1001-5515.202011087
Singh, L. K., Singh, S. P., & Sharma, P. (2026) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2026.2644503
- Authors
- Miele, D., Catenacci, L., Sorrenti, M., Rossi, S., Sandri, G., Malavasi, L., Dacarro, G., Ferrari, F., & Bonferoni, M. C.
- Affiliations
- University of Pavia (IT)
- Corresponding author
- Bonferoni, Maria Cristina
- ORCID
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2019-09-01
- Volume
- 17
- Issue
- 9
- Pages
- 515
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC6780743
- OpenAlex
- W2970791469
- Cited by
- 23
- References
- 28
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 6
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- PLGA nanoparticles, polymeric micelles, resveratrol, drug delivery systems, poorly water-soluble drugs, drug loading, amorphization, thermal stability, drug release, cellular uptake, mucoadhesion, anticancer polyphenols
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Resveratrol, Biological Availability, Curcumin, Drug Carriers, Glycolates, Glycols, HeLa Cells, Humans, Micelles, Particle Size, Polymers, Solubility, Surface Properties, Drug Delivery Systems, Caco-2 Cells, Oleic Acid, Cell Line, Tumor, Chitosan, Nanoparticles, Hydrophobic and Hydrophilic Interactions
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