Cited by 783Nanocomposite Films for Food PackagingPlant-Microbe Interactions and ImmunityStudies on Chitinases and Chitosanases

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Chitosan in Plant Protection

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El Hadrami, Abdelbasset, Adam, Lorne R., El Hadrami, Ismail, Daayf, Fouad·2010·Marine Drugs

DOI 10.3390/md8040968PMC PMC2866471

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Abstract

Chitin and chitosan are naturally-occurring compounds that have potential in agriculture with regard to controlling plant diseases. These molecules were shown to display toxicity and inhibit fungal growth and development. They were reported to be active against viruses, bacteria and other pests. Fragments from chitin and chitosan are known to have eliciting activities leading to a variety of defense responses in host plants in response to microbial infections, including the accumulation of phytoalexins, pathogen-related (PR) proteins and proteinase inhibitors, lignin synthesis, and callose formation. Based on these and other proprieties that help strengthen host plant defenses, interest has been growing in using them in agricultural systems to reduce the negative impact of diseases on yield and quality of crops. This review recapitulates the properties and uses of chitin, chitosan, and their derivatives, and will focus on their applications and mechanisms of action during plant-pathogen interactions.

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Ali, A., Zhang, J., Zhou, M., Chen, T., Shah, L., Rehman, S., Hayat, S., Shi, J., & Chen, J. (2021) · Forests · doi:10.3390/f12050557 · Cited by 15
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López‐Velázquez, J. C., Haro-González, J. N., García‐Morales, S., Espinosa‐Andrews, H., Navarro-López, D. E., Montero-Cortés, M. I., & Qui‐Zapata, J. A. (2021) · Polymers · doi:10.3390/polym13121940 · Cited by 15
“Of the three physicochemical properties considered important for the biological activity of chitosan as an elicitor, viscosity is the characteristic that has been least addressed in agricultural research [33,34].”
Background
Graphene oxide modification enhances the activity of chitosan against Fusarium graminearum in vitro and in vivo
Zhang, W., Cheng, C., Wang, R., Peng, F., Du, H., Zheng, Z., Hou, W., Yang, Y., Wang, X., & Deng, Y. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.08.168 · Cited by 15
Stimuli-responsive chitosan based nanoparticles in cancer therapy and diagnosis: A review
Fang, G., Peng, H., Qiao, R., Liu, B., Shi, X., Wang, Z., & Sun, P. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137709 · Cited by 16
Applications of Natural Polymers in the Grapevine Industry: Plant Protection and Value-Added Utilization of Waste
(Sărdărescu), D.-I. T., Mănăilă-Maximean, D., Fierăscu, I., Baroi, A. M., Matei, R. I., Fistoș, T., Chican, I. E., & Fierăscu, R. C. (2024) · Polymers · doi:10.3390/polym17010018 · Cited by 17
Eco-Friendly, Green Packaging Materials from Akaganeite and Hematite Nanoparticle-Reinforced Chitosan Nanocomposite Films
Chandrakumara, G. T. D., Dissanayake, D. M. S. N., Mantilaka, M. M. M. G. P. G., Silva, R. T. D., Pitawala, H. M. T. G. A., & de Silva, K. M. N. (2019) · Journal of Nanomaterials · doi:10.1155/2019/1049142 · Cited by 15
Effect of Chitosan and Micro-Carbon-Based Phosphorus Fertilizer on Strawberry Growth and Productivity
Metwaly, E.-S. E., AL‐Huqail, A. A., Farouk, S., & Omar, G. (2023) · Horticulturae · doi:10.3390/horticulturae9030368 · Cited by 15
The toxic effect of chitosan/metal‐impregnated textile to synanthropic mites
Ráheľ, J., Jonášová, E., Nesvorná, M., Klubal, R., Erban, T., & Hubert, J. (2012) · Pest Management Science · doi:10.1002/ps.3428 · Cited by 15
MULTIFUNCTIONAL BIOLOGICS WHICH COMBINE MICROBIAL ANTI-FUNGAL STRAINS WITH CHITOSAN IMPROVE SOFT WHEAT (Triticum aestivum L.) YIELD AND GRAIN QUALITY
Universit, S.-P. S. A., & Kolesnikov, L. E. (2019) · Sel skokhozyaistvennaya Biologiya · doi:10.15389/agrobiology.2019.5.1024eng · Cited by 15
Pesticide removal from industrial effluents using biopolymeric materials
Sanchez, L. M., Ollier, R. P., Pereira, A. D. E. S., Fraceto, L. F., & Álvarez, V. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818134-8.00015-8 · Cited by 15
Application of Chitosan and Its Derivatives Against Plant Viruses
Komarova, T. V., Shipounova, I. N., Kalinina, N. O., & Taliansky, M. E. (2024) · Polymers · doi:10.3390/polym16223122 · Cited by 14
Microbial inoculants for plant resilience performance: roles, prospects and challenges
Hajji-Hedfi, L., Dali, S., Rhouma, A., Al‐Ani, L. K. T., Chihani-Hammas, N., Khlif, A., & Bargougui, O. (2025) · Journal of Plant Diseases and Protection · doi:10.1007/s41348-025-01080-7 · Cited by 14
“For example, the application of chitosan has been shown to induce systemic resistance in Ashraf and Foolad (2007) plants against a wide range of pathogens and abiotic stress (El Hadrami et al. 2010; Lalarukh et al. 2022b).”
EFFECT OF FOLIAR SPRAYING WITH SEAWEEDS EXTRACT, CHITOSAN AND POTASSIUM SILICATE ON ROSMARINUS OFFICINALIS L. PLANTS IN SANDY SOIL
Waly, A., El-Fattah, Y. A., Hassan, M. A. E., El-Ghadban, E., & Alla, A. A. (2019) · Scientific Journal of Flowers and Ornamental Plants /Scientific Journal of Flowers and Ornamental Plants · doi:10.21608/sjfop.2019.92322 · Cited by 14
“…biodegradability. growth stimulation and seed germination, increasing nutrient uptake, reducing oxidative stress, increasing chlorophyll content, photosynthetic and chloroplast enlargement in the leaves, antifungal, antiviral and antibacterial properties (Hadrami et al., 2010 and Hadwiger, 2013).”
Background
Co-application of Biochar and Seed Priming with Nano-sized Chitosan-Proline Improves Salt Tolerance in Differentially Responding Bread Wheat Genotypes
Al-Hinai, M., Ullah, A., Al-Toubi, A.-K. M., Harrasi, I. R. A., Alamri, A. A., & Farooq, M. (2023) · Journal of soil science and plant nutrition · doi:10.1007/s42729-023-01276-6 · Cited by 17
Phosphoproteome analysis reveals chitosan-induced resistance to osmotic stress in rice ( Oryza sativa L.) seedlings
Pongprayoon, W., Maksup, S., Phaonakrop, N., Jaresitthikunchai, J., Uawisetwathana, U., Panya, A., & Roytrakul, S. (2022) · Journal of Plant Interactions · doi:10.1080/17429145.2022.2114556 · Cited by 14
“These data correlate with previous reports that chitosan stimulated an increase in peroxidase activity under stress conditions in plants (El Hadrami et al. 2010).”
Result
New Bioactive Biomaterials Based on Chitosan
Bosquez-Molina, E., & Zavaleta‐Avejar, L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802735-6.00002-1 · Cited by 12
Priming of Nicotiana benthamiana antioxidant defences using brown seaweed extracts
Esserti, S., Smaili, A., Makroum, K., Belfaiza, M., Rifai, L. A., Koussa, T., Imane, K., & Faize, M. (2017) · Journal of Phytopathology · doi:10.1111/jph.12664 · Cited by 14
Structural, Thermal and Optical Modifications of Chitosan due to UV-Ozone Irradiation
Guirguis, O. W., Abdel-Zaher, N. A., El‐Bassyouni, G. T., & Moselhey, M. T. H. (2018) · Egyptian Journal of Chemistry · doi:10.21608/ejchem.2018.2904.1241 · Cited by 13
“Chitosan and its derivatives have several applications in different fields such as: in biotechnology, improve wound healing in human, drug delivery and competent candidates for preparing composite bone cements [6], as moisturizing and conditioning product in the cosmetics industry [7] and in agriculture and textile in…”
Background
Diversity, distribution and multi‐functional attributes of bacterial communities associated with the rhizosphere and endosphere of timothy (Phleum pratenseL.)
Saleh, D., Jarry, J., Rani, M., Aliferis, K. A., Séguin, P., & Jabaji, S. H. (2019) · Journal of Applied Microbiology · doi:10.1111/jam.14334 · Cited by 13
“In this study, isolates belonging to all 16 genera had the capacity to degrade chitin and chitosan which helps in the suppression of fungal growth (Quecine et al. 2008; El Hadrami et al. 2010).”
Background
NOXA Is Important for Verticillium dahliae’s Penetration Ability and Virulence
Zhu, X., Sayari, M., Islam, M. R., & Daayf, F. (2021) · Journal of Fungi · doi:10.3390/jof7100814 · Cited by 13
Use of metabolomics data analysis to identify fruit quality markers enhanced by the application of an aminopolysaccharide
Amerany, F. E., Taourirte, M., Wahbi, S., Meddich, A., & Rhazi, M. (2021) · RSC Advances · doi:10.1039/d1ra05865g · Cited by 13
Toxicity and Preventive Activity of Chitosan, Equisetum arvense, Lecithin and Salix Cortex against Plasmopara viticola, the Causal Agent of Downy Mildew in Grapevine
Miguel, D. L. D., Mena‐Petite, A., & Díez-Navajas, A. M. (2022) · Agronomy · doi:10.3390/agronomy12123139 · Cited by 13
Synthesis of Biopolymer Based Superabsorbent: An Eco-friendly Approach Towards Future Sustainability
Sinha, S. (2023) · Engineering materials · doi:10.1007/978-981-99-3094-4_2 · Cited by 13
New polyelectrolyte complex of chitosan: Preparation, characterization, and application as a biocontrol agent carrier
Gicheva, G. D., Paneva, D., Manolova, N. E., Naydenov, M., & Rashkov, I. B. (2012) · Journal of Bioactive and Compatible Polymers · doi:10.1177/0883911512436899 · Cited by 13
In vitro cultures of Actinidia deliciosa (A. Chev) C.F. Liang & A.R. Ferguson: a tool to study the SAR induction of chitosan treatment
Corsi, B., Riccioni, L., & Forni, C. (2014) · Organic Agriculture · doi:10.1007/s13165-014-0087-x · Cited by 13
Effectiveness of environmentally safe food additives and food supplements in an in vitro growth inhibition of significant Fusarium, Aspergillus and Penicillium species
Žabka, M., & Pavela, R. (2017) · Plant Protection Science · doi:10.17221/86/2017-pps · Cited by 13
Big things come in small packages: Using nanomaterials for plant genetic engineering
Leal, G. G., dos Santos, Y. B. L., Ito, M. E. Q. S., & de Souza, W. R. (2025) · Plant Nano Biology · doi:10.1016/j.plana.2025.100219 · Cited by 12
Microbial chitin extraction and characterization from green tiger shrimp waste: A comparative study of culture mediums along with bioprocess optimization
Gharibzadeh, M., Osfouri, S., Jamekhorshid, A., & Jafari, S. A. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125213 · Cited by 12
Phenylalanine Ammonia-Lyase-Mediated Differential Response of Tomato (Solanum lycopersicum L.) Cultivars with Different Stress Tolerance to Treatment with Low-Molecular-Weight Chitosan
Timofeeva, T. A., Bubnova, A. N., Shagdarova, B. T., Варламов, В. П., & Kamionskaya, A. M. (2024) · Agronomy · doi:10.3390/agronomy14020386 · Cited by 12
Preparation and In Vitro Evaluation of Thermosensitive and Mucoadhesive Hydrogels for Intranasal Delivery of Phenobarbital Sodium
Alami-Milani, M., Salatin, S., Rayeni, F. S., & Jelvehgari, M. (2021) · Therapeutic Delivery · doi:10.4155/tde-2021-0022 · Cited by 12
Towards bio-silicon interfaces: Formation of an ultra-thin self-hydrated artificial membrane composed of dipalmitoylphosphatidylcholine (DPPC) and chitosan deposited in high vacuum from the gas-phase
Retamal, M. J., Cisternas, M. A., Gutiérrez-Maldonado, S. E., Pérez‐Acle, T., Seifert, B., Busch, M., Huber, P., & Volkmann, U. G. (2014) · The Journal of Chemical Physics · doi:10.1063/1.4894224 · Cited by 12
Effect of Chitosan as a Biological Sanitizer for Salmonella Typhimurium and Aerobic Gram Negative Spoilage Bacteria Present on Chicken Skin
Menconi, A., Hernandez-Velasco, X., Latorre, J. D., Kallapura, G., Pumford, N. R., Morgan, M. J., Hargis, B. M., & Tellez, G. (2013) · International Journal of Poultry Science · doi:10.3923/ijps.2013.318.321 · Cited by 12
“The antimicrobial activities of chitosan against foodborne pathogens has been broadly investigated in the food industry (Singla and Chawla, 2001; No et al., 2002; Senel and McClure, 2004; Petrovich et al., 2008; El-Hadrami et al., 2010; Kong et al., 2010; Vargas and Gonzalez-Martinez, 2010).”
Background
The Ceratopteris (fern) developing motile gamete walls contain diverse polysaccharides, but not pectin
Lopez, R. A., & RENZAGLIA, K. S. (2017) · Planta · doi:10.1007/s00425-017-2793-6 · Cited by 12
Efficacy of Purpureocillium lilacinum in combination with chitosan for the control of Meloidogyne javanica
Giannakou, I. O., Tasoula, V., Tsafara, P., Varimpopi, M., & Antoniou, P. P. (2020) · Biocontrol Science and Technology · doi:10.1080/09583157.2020.1756227 · Cited by 12
Mixtures of Biological Control Agents and Organic Additives Improve Physiological Behavior in Cape Gooseberry Plants under Vascular Wilt Disease
Chaves-Gómez, J. L., Chávez-Arias, C. C., Cotes, A. M., Gómez-Caro, S., & Restrepo-Díaz, H. (2021) · Plants · doi:10.3390/plants10102059 · Cited by 12
“Within this group of additives, chitosan is considered a biopesticide related to disease management [39,40].”
Background
Application of Elicitors in Grapevine Defense: Impact on Volatile Compounds
Salifu, R., Chen, C., Sam, F. E., & Jiang, Y. (2022) · Horticulturae · doi:10.3390/horticulturae8050451 · Cited by 12
PR-Proteins Accumulation in Tomato Plant Due to Application of Resistance Inducing Chemicals During Period of Induced Resistance Against Alternaria Leaf Blight
Raut, S., & Borkar, S. G. (2014) · Science International · doi:10.17311/sciintl.2014.72.75 · Cited by 12
Activation of Early Defense Signals in Seedlings of Nicotiana benthamiana Treated with Chitin Nanoparticles
López, M., Miranda, E., Ramos, C., García, H., & Neira‐Carrillo, A. (2020) · Plants · doi:10.3390/plants9050607 · Cited by 11
“Currently, chitosan, a chemical derivative of chitin, is widely used in agriculture and has demonstrated a direct antimicrobial and bio-stimulant effect on plant systems [33].”
Background
Biodegradable Carboxymethyl Chitosan/Polyvinyl Alcohol Hymexazol-Loaded Mulch Film for Soybean Root Rot Control
Lv, Z., Meng, X., Sun, S., Jiang, T., Zhang, S., & Feng, J. (2023) · Agronomy · doi:10.3390/agronomy13092205 · Cited by 11
Changes of Postharvest Nutritional Quality and Antioxidant Enzymes in ‘Haribhanga’ Mango by Aloe vera Gel with Chitosan and Coconut Oil Coating During Ambient Storage
Begum, L., Ahmed, M., Rahman, A., Rahman, M. H., Arfin, M. S., Akter, N., & Islam, T. (2023) · Journal of Horticultural Research · doi:10.2478/johr-2023-0024 · Cited by 11
Crack Repair in In-Service Tunnel Linings Using Chitosan-Combined Enzyme-Induced Carbonate Precipitation
Yuan, H., Ru, M., Dong, W., Zhu, X., & Zhao, Z. (2024) · Journal of Materials in Civil Engineering · doi:10.1061/jmcee7.mteng-18327 · Cited by 11

Authors: El Hadrami, A., Adam, L. R., El Hadrami, I., & Daayf, F.
Affiliations: University of Manitoba, Department of Plant Science, 222, Agriculture Building, Winnipeg, Manitoba, R3T 2N2, Canada
University of Manitoba (CA)
Laboratoire de Biotechnologies, Protection et Valorisation des Ressources Végétales (Biotec-VRV), Faculté des Sciences Semlalia, B.P. 2390, 40 000, Marrakech, Morocco
Corresponding author: Daayf, Fouad
ORCID: Daayf, Fouad
Venue: Marine Drugs
Publisher: MDPI AG
Published: 2010-03-30
Volume: 8
Issue: 4
Pages: 968-987
ISSN: 1660-3397 (ISSN-L)
DOI: 10.3390/md8040968
PMC: PMC2866471
OpenAlex: W2064011765
Cited by: 783
References: 123
Citations by year: 2026: 54 · 2025: 56 · 2024: 51 · 2023: 85 · 2022: 74 · 2021: 63 · 2020: 82 · 2019: 57 · 2018: 39 · 2017: 47 · 2016: 44 · 2015: 29 · 2014: 35 · 2013: 29 · 2012: 21
FWCI: 1.04
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Marine Drugs (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Natural Sciences and Engineering Research Council of Canada
Topics: Physical Sciences › Materials Science › Biomaterials › Nanocomposite Films for Food Packaging
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Studies on Chitinases and Chitosanases
Keywords: chitosan, chitin, plant disease control, plant defense response, elicitation, phytoalexins, pathogenesis-related proteins, protease inhibitors, lignin biosynthesis, callose deposition, antifungal activity, antiviral activity, plant-pathogen interaction, chitosan derivatives, biopesticides
MeSH terms: Agriculture, Anti-Infective Agents, Chitin, Plant Diseases, Plants, Crops, Agricultural, Chitosan

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