The gut-skin axis in health and disease: A paradigm with therapeutic implications
Open accessAbstract
As crucial interface organs gut and skin have much in common. Therefore it is unsurprising that several gut pathologies have skin co-morbidities. Nevertheless, the reason for this remains ill explored, and neither mainstream gastroenterology nor dermatology research have systematically investigated the 'gut-skin axis'. Here, in reviewing the field, we propose several mechanistic levels on which gut and skin may interact under physiological and pathological circumstances. We focus on the gut microbiota, with its huge metabolic capacity, and the role of dietary components as potential principle actors along the gut-skin axis. We suggest that metabolites from either the diet or the microbiota are skin accessible. After defining open key questions around the nature of these metabolites, how they are sensed, and which cutaneous changes they can induce, we propose that understanding of these pathways will lead to novel therapeutic strategies based on targeting one organ to improve the health of the other.
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Mounting evidence suggests probiotics may play a significant role in skin health via regulating intestinal microbiota and metabolites and improving systemic immunity.
“Mounting evidence suggests that probiotics may play a significant role in skin health via regulating intestinal microbiota and metabolites and improving systemic immunity [79,138,139,140].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [79]
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The gut microbiome as a major regulator of the gut-skin axis
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Targeting the gut‐skin axis—Probiotics as new tools for skin disorder management?
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Acne, Microbiome, and Probiotics: The Gut–Skin Axis
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Boosting the Photoaged Skin: The Potential Role of Dietary Components
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Non-Melanoma Skin Cancer: news from microbiota research
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- Authors
- O'Neill, C. A., Monteleone, G., McLaughlin, J. T., & Paus, R.
- Affiliations
- Dermatology Research Centre, Institute of Inflammation and Repair University of Manchester and Manchester Academic Health Sciences Centre Manchester UK
- University of Rome Tor Vergata (IT)
- Manchester Academic Health Science Centre (GB)
- University of Münster (DE)
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 2016-08-24
- Volume
- 38
- Issue
- 11
- Pages
- 1167-1176
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2511062914
- Cited by
- 449
- References
- 115
- Citations by year
- 2026: 34 · 2025: 69 · 2024: 76 · 2023: 50 · 2022: 79 · 2021: 59 · 2020: 35 · 2019: 25 · 2018: 12 · 2017: 8 · 2016: 1
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- BioEssays (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut-skin axis, gut microbiota, dietary metabolites, skin barrier, metabolite sensing, treatment options
- MeSH terms
- Gastrointestinal Microbiome, Bacteria, Diet, Humans, Intestines, Skin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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