Cited by 449Gut microbiota and healthDermatology and Skin DiseasesGastrointestinal motility and disorders

The gut-skin axis in health and disease: A paradigm with therapeutic implications

Open access
O'Neill, Catherine A., Monteleone, Giovanni, McLaughlin, John T., Paus, Ralf·2016·BioEssays

Abstract

As crucial interface organs gut and skin have much in common. Therefore it is unsurprising that several gut pathologies have skin co-morbidities. Nevertheless, the reason for this remains ill explored, and neither mainstream gastroenterology nor dermatology research have systematically investigated the 'gut-skin axis'. Here, in reviewing the field, we propose several mechanistic levels on which gut and skin may interact under physiological and pathological circumstances. We focus on the gut microbiota, with its huge metabolic capacity, and the role of dietary components as potential principle actors along the gut-skin axis. We suggest that metabolites from either the diet or the microbiota are skin accessible. After defining open key questions around the nature of these metabolites, how they are sensed, and which cutaneous changes they can induce, we propose that understanding of these pathways will lead to novel therapeutic strategies based on targeting one organ to improve the health of the other.

Integrity signals

Registry

Crossref · 10.1002/bies.201600008

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115 of 115 references verified0 citation errors · 0 not checkable

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  • Mounting evidence suggests probiotics may play a significant role in skin health via regulating intestinal microbiota and metabolites and improving systemic immunity.

    “Mounting evidence suggests that probiotics may play a significant role in skin health via regulating intestinal microbiota and metabolites and improving systemic immunity [79,138,139,140].”

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Authors
O'Neill, C. A., Monteleone, G., McLaughlin, J. T., & Paus, R.
Affiliations
  • Dermatology Research Centre, Institute of Inflammation and Repair University of Manchester and Manchester Academic Health Sciences Centre Manchester UK
  • University of Rome Tor Vergata (IT)
  • Manchester Academic Health Science Centre (GB)
  • University of Münster (DE)
Venue
BioEssays
Publisher
Wiley
Published
2016-08-24
Volume
38
Issue
11
Pages
1167-1176
ISSN
  • 0265-9247 (ISSN-L)
  • 1521-1878
OpenAlex
W2511062914
Cited by
449
References
115
Citations by year
2026: 34 · 2025: 69 · 2024: 76 · 2023: 50 · 2022: 79 · 2021: 59 · 2020: 35 · 2019: 25 · 2018: 12 · 2017: 8 · 2016: 1
FWCI
1.39
Type
journal article
Language
en
Locations
  • BioEssays (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion, other-oa)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
gut-skin axis, gut microbiota, dietary metabolites, skin barrier, metabolite sensing, treatment options
MeSH terms
Gastrointestinal Microbiome, Bacteria, Diet, Humans, Intestines, Skin

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