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Probiotics and Colon Cancer
Open accessAbstract
Literature has recently highlighted the enormous scientific interest on the relationship between the gut microbiota and colon cancer, and how the use of some selected probiotics can have a future impact on the adverse events which occur during this disease. Although there is no clear evidence to claim that probiotics are effective in people with cancer, recent reviews have found that probiotics can significantly reduce the incidence of diarrhea and the average frequency of daily bowel movements. However, most of this evidence needs to be more clinically convincing and further discussed. Undoubtedly, some probiotics, when properly dosed and administered, can have a strong rebalance effect on the gut microbiota and as a consequence a possible positive action on immune modulation of the gastrointestinal tract and on inflammation of the intestinal mucosa. Many recent findings indeed support the hypothesis that the daily use of some selected probiotics can be a feasible approach to effectively protect patients against the risk of some severe consequences due to radiation therapy or chemotherapy. This paper aims to review the most recent articles in order to consider a possible adjuvant approach for the use of certain well-balanced probiotics to help prevent colon cancer and the adverse effects caused by related therapies.
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“The human gastrointestinal tract is where most probiotic actions [47,48] occur and where colon cancer originates.”
From Bioprophylactic potential of novel human colostrum probiotics via apoptotic induction of colon cancer cells and cell immune activation (2022) · cites this paper as [48]
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Metadata
- Authors
- Drago, L.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Drago, Lorenzo
- ORCID
- Drago, Lorenzo
- Venue
- Microorganisms
- Publisher
- MDPI AG
- Published
- 2019-02-28
- Volume
- 7
- Issue
- 3
- Pages
- 66
- ISSN
- 2076-2607 (ISSN-L)
- PMC
- PMC6463067
- OpenAlex
- W2917015735
- Cited by
- 171
- References
- 61
- Citations by year
- 2026: 11 · 2025: 19 · 2024: 25 · 2023: 27 · 2022: 33 · 2021: 24 · 2020: 27 · 2019: 3
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Microorganisms (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- probiotics, colon cancer, gut microbiota, cancer prevention, chemotherapy side effects, radiotherapy complications, diarrhea, stool frequency, immunomodulation, intestinal mucosa inflammation, adjuvant therapy
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