The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Colistin Update on Its Mechanism of Action and Resistance, Present and Future Challenges
Open accessAbstract
Colistin has been extensively used since the middle of the last century in animals, particularly in swine, for the control of enteric infections. Colistin is presently considered the last line of defense against human infections caused by multidrug-resistant Gram-negative organisms such as carbapenemase-producer Enterobacterales, Acinetobacter baumanni, and Pseudomonas aeruginosa. Transferable bacterial resistance like mcr-genes was reported in isolates from both humans and animals. Researchers actively seek strategies to reduce colistin resistance. The definition of guidelines for colistin therapy in veterinary and human medicine is thus crucial. The ban of colistin use in swine as a growth promoter and for prophylactic purposes, and the implementation of sustainable measures in farm animals for the prevention of infections, would help to avoid resistance and should be encouraged. Colistin resistance in the human–animal–environment interface stresses the relevance of the One Health approach to achieve its effective control. Such measures should be addressed in a cooperative way, with efforts from multiple disciplines and with consensus among doctors, veterinary surgeons, and environment professionals. A revision of the mechanism of colistin action, resistance, animal and human use, as well as colistin susceptibility evaluation is debated here.
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Cited by
Molecular mechanisms of antibiotic resistance revisited
Darby, E. M., Trampari, E., Siasat, P., Gaya, M. S., Alav, I., Webber, M. A., & Blair, J. M. A. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00820-y · Cited by 1,398
Metadata
- Authors
- Andrade, F. F., Silva, D., Rodrigues, A., & Pina-Vaz, C.
- Venue
- Microorganisms
- Publisher
- MDPI AG
- Published
- 2020-11-02
- Volume
- 8
- Issue
- 11
- Pages
- 1716
- ISSN
- 2076-2607 (ISSN-L)
- OpenAlex
- W3096406157
- Cited by
- 284
- References
- 54
- FWCI
- 8.94
- Type
- journal article
- Language
- en
- Open access
- gold
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- Andrade, F. F., Silva, D., Rodrigues, A., & Pina-Vaz, C. (2020). Colistin Update on Its Mechanism of Action and Resistance, Present and Future Challenges. Microorganisms. https://doi.org/10.3390/microorganisms8111716
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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