The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Anti-carcinogenic Effects of the Flavonoid Luteolin
Open accessAbstract
Luteolin is a flavonoid which is part of our daily nutrition in relatively low amounts (less than 1 mg/day). Nevertheless, some epidemiological studies suggest an inverse correlation between luteolin intake and the risk of some cancer types. Luteolin displays specific anti-inflammatory and anti-carcinogenic effects, which can only partly be explained by its anti-oxidant and free radical scavenging capacities. Luteolin can delay or block the development of cancer cells in vitro and in vivo by protection from carcinogenic stimuli, by inhibition of tumor cell proliferation, by induction of cell cycle arrest and by induction of apoptosis via intrinsic and extrinsic signaling pathways. When compared to other flavonoids, luteolin was usually among the most effective ones, inhibiting tumor cell proliferation with IC50 values between 3 and 50 μM in vitro and in vivo by 5 to 10 mg/kg i.p., intragastric application of 0.1–0.3 mg/kg/d, or as food additive in concentrations of 50 to 200 ppm. Luteolin has been shown to penetrate into human skin, making it also a candidate for the prevention and treatment of skin cancer.
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Cites
The Chemistry behind Antioxidant Capacity Assays
Huang, D., Ou, B., & Prior, R. L. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030723c · Cited by 6,162
Cited by
Ferreira, J. F. S., Luthria, D. L., Sasaki, T., & Heyerick, A. (2010) · Molecules · doi:10.3390/molecules15053135 · Cited by 531
Luteolin as a modulator of skin aging and inflammation
Gendrisch, F., Esser, P. R., Schempp, C. M., & Wölfle, U. (2021) · BioFactors · doi:10.1002/biof.1699 · Cited by 357
Self-citationGonzález-Vallinas, M., González-Castejón, M., Rodríguez-Casado, A., & Ramírez de Molina, A. (2013) · Nutrition Reviews · doi:10.1111/nure.12051 · Cited by 302
Zhu, J., Wang, H., Chen, F., Fu, J., Xu, Y., Hou, Y., Kou, H. H., Zhai, C., Nelson, M. B., Zhang, Q., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.09.010 · Cited by 162
Growth inhibitory effect of grape phenolics against wine spoilage yeasts and acetic acid bacteria
Pastorkova, E., Zakova, T., Landa, P., Novakova, J., Vadlejch, J., & Kokoska, L. (2013) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2012.12.018 · Cited by 64
Metadata
- Authors
- Seelinger, G., Merfort, I., Wölfle, U., & Schempp, C. M.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2008-10-22
- Volume
- 13
- Issue
- 10
- Pages
- 2628-2651
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2120130492
- Cited by
- 369
- References
- 1
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- gold
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- Seelinger, G., Merfort, I., Wölfle, U., & Schempp, C. M. (2008). Anti-carcinogenic Effects of the Flavonoid Luteolin. Molecules. https://doi.org/10.3390/molecules13102628
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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