The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
Flavonoids from Artemisia annua L. as Antioxidants and Their Potential Synergism with Artemisinin against Malaria and Cancer
Open accessAbstract
Artemisia annua is currently the only commercial source of the sesquiterpene lactone artemisinin.Since artemisinin was discovered as the active component of A. annua in early 1970s, hundreds of papers have focused on the anti-parasitic effects of artemisinin and its semi-synthetic analogs dihydroartemisinin, artemether, arteether, and artesunate. Artemisinin per se has not been used in mainstream clinical practice due to its poor bioavailability when compared to its analogs. In the past decade, the work with artemisinin-based compounds has expanded to their anti-cancer properties. Although artemisinin is a major bioactive component present in the traditional Chinese herbal preparations (tea), leaf flavonoids, also present in the tea, have shown a variety of biological activities and may synergize the effects of artemisinin against malaria and cancer. However, only a few studies have focused on the potential synergistic effects between flavonoids and artemisinin. The resurgent idea that multi-component drug therapy might be better than monotherapy is illustrated by the recent resolution of the World Health Organization to support artemisinin-based combination therapies (ACT), instead of the previously used monotherapy with artemisinins. In this critical review we will discuss the possibility that artemisinin and its semi-synthetic analogs might become more effective to treat parasitic diseases (such as malaria) and cancer if simultaneously delivered with flavonoids. The flavonoids present in A. annua leaves have been linked to suppression of CYP450 enzymes responsible for altering the absorption and metabolism of artemisinin in the body, but also have been linked to a beneficial immunomodulatory activity in subjects afflicted with parasitic and chronic diseases.
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Cites
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MethodFlavonoids: a review of probable mechanisms of action and potential applications
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Cited by
Rasoanaivo, P., Wright, C. W., Willcox, M. L., & Gilbert, B. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-s1-s4 · Cited by 566
An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications
Hossain, U., Das, A. K., Ghosh, S., & Sil, P. C. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111738 · Cited by 438
Percário, S., Moreira, D., Gomes, B., Ferreira, M., Gonçalves, A., Laurindo, P., Vilhena, T., Dolabela, M., & Green, M. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131216346 · Cited by 363
Sesquiterpene Lactones from Artemisia Genus: Biological Activities and Methods of Analysis
Ivanescu, B., Miron, A., & Corciova, A. (2015) · Journal of Analytical Methods in Chemistry · doi:10.1155/2015/247685 · Cited by 201
“One plant species usually produces one type of sesquiterpene lactones, found chiefly in leaves and flowers in concentrations of 0.01% to 8% dry weight [5, 10].”
BackgroundInfluentialElfawal, M. A., Towler, M. J., Reich, N. G., Weathers, P. J., & Rich, S. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413127112 · Cited by 124
Metadata
- Authors
- Ferreira, J. F. S., Luthria, D. L., Sasaki, T., & Heyerick, A.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2010-04-29
- Volume
- 15
- Issue
- 5
- Pages
- 3135-3170
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2028765375
- Cited by
- 531
- References
- 141
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ferreira, J. F. S., Luthria, D. L., Sasaki, T., & Heyerick, A. (2010). Flavonoids from Artemisia annua L. as Antioxidants and Their Potential Synergism with Artemisinin against Malaria and Cancer. Molecules. https://doi.org/10.3390/molecules15053135
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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