The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine
Open accessAbstract
Withania somnifera, commonly known as Ashwagandha, is an important medicinal plant that has been used in Ayurvedic and indigenous medicine for over 3,000 years. In view of its varied therapeutic potential, it has also been the subject of considerable modern scientific attention. The major chemical constituents of the Withania genus, the withanolides, are a group of naturally occurring C28-steroidal lactone triterpenoids built on an intact or rearranged ergostane framework, in which C-22 and C-26 are appropriately oxidized to form a six-membered lactone ring. In recent years, numerous pharmacological investigations have been carried out into the components of W. somnifera extracts. We present here an overview of the chemical structures of triterpenoid components and their biological activity, focusing on two novel activities, tumor inhibition and antiangiogenic properties of withaferin A and the effects of withanolide A on Alzheimer's disease. The most recent attempts in biotechnological production of withanolides are also discussed.
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Cites
Bhattacharya, S. K., & Muruganandam, A. V. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00110-2 · Cited by 344
Search for natural products related to regeneration of the neuronal network
Tohda, C., Kuboyama, T., & Komatsu, K. (2005) · Neurosignals · doi:10.1159/000085384 · Cited by 257 · cited 1×
“Dentritic atrophy was completely prevented by treatment with these withanolides, particularly withanoside IV and VI [60].”
BackgroundNeuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats
Ahmad, M., Saleem, S., Ahmad, A. S., Ansari, M. A., Yousuf, S., Hoda, M. N., & Islam, F. (2005) · Human & Experimental Toxicology · doi:10.1191/0960327105ht509oa · Cited by 227
Cited by
Pharmacologic overview of Withania somnifera, the Indian Ginseng
Dar, N. J., Hamid, A., & Ahmad, M. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2012-1 · Cited by 370
Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., Saha, S. C., Patil, M. T., Kandimalla, R., Proćków, J., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112175 · Cited by 306
Moses, T., Pollier, J., Thevelein, J. M., & Goossens, A. (2013) · New Phytologist · doi:10.1111/nph.12325 · Cited by 245
Lopresti, A. L., Smith, S. J., Malvi, H., & Kodgule, R. (2019) · Medicine · doi:10.1097/md.0000000000017186 · Cited by 241
Björnsson, H. K., Björnsson, E. S., Avula, B., Khan, I. A., Jonasson, J. G., Ghabril, M., Hayashi, P. H., & Navarro, V. (2020) · Liver International · doi:10.1111/liv.14393 · Cited by 125
Metadata
- Authors
- Mirjalili, M. H., Moyano, E., Bonfill, M., Cusido, R. M., & Palazón, J.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2009-07-03
- Volume
- 14
- Issue
- 7
- Pages
- 2373-2393
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2108763926
- Cited by
- 642
- References
- 3
- FWCI
- 39.93
- Type
- journal article
- Language
- en
- Open access
- gold
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- Mirjalili, M. H., Moyano, E., Bonfill, M., Cusido, R. M., & Palazón, J. (2009). Steroidal Lactones from Withania somnifera, an Ancient Plant for Novel Medicine. Molecules. https://doi.org/10.3390/molecules14072373
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