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Essential Oil of Myrtus communis L. as a Potential Antioxidant and Antimutagenic Agents
Open accessAbstract
The present study describes DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity and antimutagenic properties of the essential oil of myrtle (Myrtus communis L.). Plant samples were collected from the two distant localities (southernmost and northern point) of the Montenegro coastline. Chemical profiles of the two samples were evaluated by GC-MS. In both of the samples monoterpenes were found to be the predominant compounds. Among them alpha-pinene, linalool, 1,8-cineole, and myrtenyl acetate were the major compounds. Significant differences between the samples were found in the ranges of alpha-pinene (14.7%-35.9%) and myrtenyl acetate (5.4%-21.6%). Both oils exhibited moderate DPPH scavenging activity, with IC50 values of 6.24 mg/mL and 5.99 mg/mL. The antimutagenic properties were assayed against spontaneous and t-BOOH-induced mutagenesis in Escherichia coli oxyR mutant IC202, a bacterial strain deficient in removing ROS. Reduction of the spontaneous mutagenesis in presence of myrtle EO was only slight, up to 13% at the highest concentration tested. When the oxidative mutagen was used, EO expressed higher reduction of mutagenesis, in a concentration dependent manner, with statistical significance for effect at the highest concentration tested (28%). Suppression of t-BOOH induced mutagenesis was correlated with the observed scavenging activity.
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“The authors identified 1,8-cineole and methyl eugenol as the components responsible for the moderate antioxidant activity of the essential oils of Myrtus communis L..”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [63]
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Cites
Biological effects of essential oils—A review
Bakkali, F., Averbeck, S., Averbeck, D., & Idaomar, M. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.106 · Cited by 7,929
Dietary Carcinogens and Anticarcinogens
Ames, B. N. (1983) · Science · doi:10.1126/science.6351251 · Cited by 2,975
DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems
Halliwell, B. B., & Aruoma, O. I. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80347-6 · Cited by 1,537
Antioxidant activity of selected essential oil components in two lipid model systems
Ruberto, G., & Baratta, M. T. (2000) · Food Chemistry · doi:10.1016/s0308-8146(99)00247-2 · Cited by 1,204
Božin, B. N., Mimica–Dukić, N., Simin, N. Đ., & Anačkov, G. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf051922u · Cited by 806
Self-citationFlavonoid content of several vegetables and their antioxidant activity
Chu, Y., Chang, C., & Hsu, H. (2000) · Journal of the Science of Food and Agriculture · doi:10.1002/(sici)1097-0010(200004)80:5 · Cited by 729
Espı́n, J. C., Soler‐Rivas, C., & Wichers, H. J. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9908188 · Cited by 702
Fundamental Aspects of Reactive Oxygen Species, or What's the Matter with Oxygen?
Fridovich, I. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07814.x · Cited by 541
Antimicrobial and Antioxidant Activities of ThreeMenthaSpecies Essential Oils
Mimica–Dukić, N., Božin, B. N., Sokóvić, M., Mihajlović, B., & Matavulj, M. (2003) · Planta Medica · doi:10.1055/s-2003-39704 · Cited by 503
Self-citationAntimicrobial and Antioxidant Activities of Melissa officinalis L. (Lamiaceae) Essential Oil
Mimica‐Dukić, N., Božin, B. N., Sokóvić, M., & Simin, N. Đ. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030698a · Cited by 488
Self-citationGardeli, C., VASSILIKI, P., Mallouchos, A., KIBOURIS, T., & Komaitis, M. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.09.036 · Cited by 395
Antioxidants and atherosclerosis. A current assessment.
Steinberg, D. (1991) · Circulation · doi:10.1161/01.cir.84.3.1420 · Cited by 394
Biochemical activities of Iranian Mentha piperita L. and Myrtus communis L. essential oils
Yadegarinia, D., Gachkar, L., Rezaei, M. B., Taghizadeh, M., Astaneh, S. D. A., & Rasooli, I. (2006) · Phytochemistry · doi:10.1016/j.phytochem.2006.04.025 · Cited by 340
Oliński, R., Gackowski, D., Foksiński, M., Różalski, R., Roszkowski, K., & Jaruga, P. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00878-x · Cited by 283
Antimutagens and anticarcinogens: A survey of putative interceptor molecules
Hartman, P. E., & Shankel, D. M. (1990) · Environmental and Molecular Mutagenesis · doi:10.1002/em.2850150305 · Cited by 264
The antioxidant hypothesis of cardiovascular disease: epidemiology and mechanisms
GEY, K. F. (1990) · Biochemical Society Transactions · doi:10.1042/bst0181041 · Cited by 258
Zhang, L., & Demain, A. L. (2005) · Humana Press eBooks · doi:10.1007/978-1-59259-976-9 · Cited by 208
Terpenoids As Therapeutic Drugs and Pharmaceutical Agents
Wang, G., Tang, W., & Bidigare, R. R. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-976-9_9 · Cited by 195
Cakir, A. (2004) · Biochemical Systematics and Ecology · doi:10.1016/j.bse.2003.11.010 · Cited by 175
Mitić-Ćulafić, D., Žegura, B., Nikolić, B., Vuković‐Gačić, B., Knežević‐Vukčević, J., & Filipič, M. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.11.015 · Cited by 168
Self-citationHayder, N., Bouhlel, I., Skandrani, I., Kadri, M., Steiman, R. L., Guiraud, P., Mariotte, A., Ghedira, K., Dijoux‐Franca, M., & Ghédira, L. C. (2008) · Toxicology in Vitro · doi:10.1016/j.tiv.2007.11.015 · Cited by 144
Naturally Occurring Antioxidants
Larson, R. A. (1997) · Medical Entomology and Zoology · Cited by 138
Ikken, Y., Morales, P., Martínez, A., Marín, M. L., Haza, A. I., & Rodríguez, M. I. C. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990166n · Cited by 134
Anti-genotoxic and free-radical scavenging activities of extracts from (Tunisian) Myrtus communis
Hayder, N., Abdelwahed, A., Kilani, S., Ammar, R. B., Mahmoud, A. A., Ghedira, K., & Ghédira, L. C. (2004) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2004.08.001 · Cited by 119
Botsoglou, N. A., Govaris, A., Botsoglou, E., Grigoropoulou, S. H., & Papageorgiou, G. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf021034o · Cited by 118
Elfellah, M. S., Akhter, M. H., & Khan, M. (1984) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(84)90073-4 · Cited by 117
Antibacterial Activity of the Crude Extracts and Fractionated Constituents of Myrtus communis
Mansouri, S., Foroumadi, A., Ghaneie, T., & Najar, A. G. (2001) · Pharmaceutical Biology · doi:10.1076/phbi.39.5.399.5889 · Cited by 114
Antimicrobial activity of essential oils from Tunisian aromatic plants
Bouzouita, N., Kachouri, F., Hamdi, M., & Chaabouni, M. M. (2003) · Flavour and Fragrance Journal · doi:10.1002/ffj.1200 · Cited by 112
Chemical Composition of Myrtle Leaf Essential Oil from Corsica (France)
Bradesi, P., Tomi, F., Casanova, J., Costa, J., & Bernardini, A. F. (1997) · Journal of Essential Oil Research · doi:10.1080/10412905.1997.10554245 · Cited by 104
Nutrient antioxidants in some herbs and Mediterranean plant leaves
Demo, A., Petrakis, C., Kefalas, P., & Boskou, D. G. (1998) · Food Research International · doi:10.1016/s0963-9969(98)00086-6 · Cited by 103
Protective effect of basil (Ocimum basilicum L.) against oxidative DNA damage and mutagenesis
Berić, T., Nikolić, B., Stanojević, J., Vuković‐Gačić, B., & Knežević‐Vukčević, J. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.09.102 · Cited by 88
Self-citationInhibition of benzo[a]pyrene- and cyclophoshamide-induced mutagenicity by Cinnamomum cassia
Sharma, N., Trikha, P., Athar, M., & Raisuddin, S. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00198-1 · Cited by 83
The Chemical Composition of Spanish Myrtle Oils. Part II
Boelens, M. H., & Jiménez, R. (1992) · Journal of Essential Oil Research · doi:10.1080/10412905.1992.9698084 · Cited by 83
Causes and consequences of oxidative stress in Alzheimer’s disease
Smith, M. A., Perry, G. L., & Pryor, W. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00793-1 · Cited by 71
Screening for antioxidant activity of essential oils obtained from spices
Lagouri, V., & Boskou, D. (1995) · Developments in food science · doi:10.1016/s0167-4501(06)80203-7 · Cited by 56
Plant Antimutagenic Agents, 1. General Bioassay and Isolation Procedures
Wall, M. E., Wani, M. C., Hughes, T. J., & Taylor, H. (1988) · Journal of Natural Products · doi:10.1021/np50059a009 · Cited by 54
New Escherichia coli WP2 tester strains highly sensitive to reversion by oxidative mutagens
Blanco, M., Urios, A., & Martínez‐Romero, A. (1998) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(98)00013-8 · Cited by 54
Lipoprotein oxidation, antioxidants and cardiovascular risk: epidemiologic evidence
van de Vijver, L. P. L., Kardinaal, A. F. M., Grobbee, D. E., Princen, H. M. G., & van Poppel, G. (1997) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(97)90432-4 · Cited by 49
Antimutagenic activity of Myrtus communis L. using the Salmonella microsome assay
Hayder, N., Skandrani, I., Kilani, S., Bouhlel, I., Abdelwahed, A., Ammar, R. B., Mahmoud, A. A., Ghédira, K., & Ghédira, L. C. (2007) · South African Journal of Botany · doi:10.1016/j.sajb.2007.10.001 · Cited by 40
Urios, A., & Blanco, M. (1996) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(96)00043-7 · Cited by 23
Flagged first, then by citations
1 of the 41 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Loliger, 1991, Natural antioxidants, Lipid Technol., 3, 58
- Charalambous, G. (1995). Food Flavors: Generation, Analysis and Process Influence, Elsevier Science B.V.
- McLafferty, F.W. (2005). Wiley Registry™ of Mass Spectral Data, John Wiley & Sons, Ltd.. [7th ed.].
Cited by
Sorted by citations
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Miguel, M. G. (2010) · Molecules · doi:10.3390/molecules15129252 · Cited by 933
Fakchich, J., & Elachouri, M. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113200 · Cited by 647
Antioxidant Activity of Spices and Their Impact on Human Health: A Review
Yashin, A. Y., Yashin, Y. I., Xia, X., & Nemzer, B. V. (2017) · Antioxidants · doi:10.3390/antiox6030070 · Cited by 527
Antimicrobial and antioxidative activity of extracts and essential oils of Myrtus communis L.
Sabo, V. A., & Knežević, P. (2013) · Microbiological Research · doi:10.1016/j.micres.2013.10.003 · Cited by 391
Review of Pharmacological Effects ofMyrtus communisL. and its Active Constituents
Alipour, G., Dashti, S., & Hosseinzadeh, H. (2014) · Phytotherapy Research · doi:10.1002/ptr.5122 · Cited by 253
Metadata
- Authors
- Mimica-Dukić, N., Bugarin, D., Grbović, S., Mitić-Ćulafić, D., Vuković-Gačić, B., Orčić, D., Jovin, E., & Couladis, M.
- Affiliations
- Department of Chemistry, Biochemistry and Environmental Protection, University of Novi Sad Faculty of Sciences. Trg Dositeja Obradovica 3. 21 000 Novi Sad, Serbia
- University of Novi Sad (RS)
- University of Belgrade (RS)
- Chair of Microbiology, Faculty of Biology, University of Belgrade. Studentski Trg 3/II, 11 000 Belgrade, Serbia
- National and Kapodistrian University of Athens (GR)
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2010-04-15
- Volume
- 15
- Issue
- 4
- Pages
- 2759-2770
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6257387
- OpenAlex
- W2084316454
- Cited by
- 195
- References
- 41
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 14 · 2023: 14 · 2022: 13 · 2021: 11 · 2020: 10 · 2019: 14 · 2018: 14 · 2017: 17 · 2016: 15 · 2015: 13 · 2014: 20 · 2013: 15 · 2012: 6
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Science and Engineering Research Board
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Myrtus communis, myrtle essential oil, antioxidant activity, antimutagenic activity, DPPH radical scavenging, monoterpenes, α-pinene, myrtenyl acetate, linalool, 1,8-cineole, chemical composition, Montenegro coast
- MeSH terms
- Biphenyl Compounds, Escherichia coli, Free Radicals, Oils, Volatile, Picrates, Repressor Proteins, Free Radical Scavengers, Mutagenesis, Antimutagenic Agents, Escherichia coli Proteins, Myrtus
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