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Antimicrobial Metabolites from the Endophytic Fungus Pichia guilliermondii Isolated from Paris polyphylla var. yunnanensis
Open accessAbstract
Three steroids and one nordammarane triterpenoid were isolated for the first time from the endophytic fungus Pichia guilliermondii Ppf9 derived from the medicinal plant Paris polyphylla var. yunnanensis. By means of physicochemical and spectrometric analysis, they were identified as ergosta-5,7,22-trienol (1), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (2), ergosta-7,22-dien-3β,5α,6β-triol (3), and helvolic acid (4). Both micro-dilution-colorimetric and spore germination assays were employed to evaluate their antimicrobial activity. Among them, helvolic acid (4) exhibited the strongest antibacterial activity against all test bacteria, with MIC values ranging from 1.56 µg/mL to 50 µg/mL, and IC50 values from 0.98 µg/mL to 33.19 µg/mL. It also showed strong inhibitory activity on the spore germination of Magnaporthe oryzae with an IC50 value of 7.20 µg/mL. Among the three steroids, 5α,8α-epidioxyergosta-6,22-dien-3β-ol (2) exhibited relatively strong antimicrobial activity. The results suggest that the endophytic fungus Pichia guillermondii Ppf9 could be a candidate for producing helvolic acid, and the metabolites from this fungus could be potentially developed as antimicrobial agents in the future.
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Gunatilaka, A. A. L. (2006) · Journal of Natural Products · doi:10.1021/np058128n · Cited by 1,032
Recent developments and future prospects of antimicrobial metabolites produced by endophytes
Yu, H., Zhang, L., Li, L., Zheng, C., Guo, L., Li, W., Sun, P., & Qin, L. (2010) · Microbiological Research · doi:10.1016/j.micres.2009.11.009 · Cited by 442
Cited by
Endophytic fungi from medicinal plants: a treasure hunt for bioactive metabolites
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Mukherjee, P. K., Chandra, J., Retuerto, M., Sikaroodi, M., Brown, R. E., Jurevic, R., Salata, R. A., Lederman, M. M., Gillevet, P. M., & Ghannoum, M. A. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003996 · Cited by 337
Endophytic Fungi—Alternative Sources of Cytotoxic Compounds: A Review
Uzma, F., Mohan, C. D., Hashem, A., Konappa, N. M., Rangappa, S., Kamath, P. V., Singh, B. P., Mudili, V., Gupta, V. K., Siddaiah, C. N., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00309 · Cited by 293
Natural products as reservoirs of novel therapeutic agents
Mushtaq, S., Abbasi, B. H., Uzair, B., & Abbasi, R. (2018) · EXCLI journal · doi:10.17179/excli2018-1174 · Cited by 257
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Metadata
- Authors
- Zhao, J., Mou, Y., Shan, T., Li, Y., Zhou, L., Wang, M., & Wang, J.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2010-11-05
- Volume
- 15
- Issue
- 11
- Pages
- 7961-7970
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2153137891
- Cited by
- 170
- References
- 2
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhao, J., Mou, Y., Shan, T., Li, Y., Zhou, L., Wang, M., & Wang, J. (2010). Antimicrobial Metabolites from the Endophytic Fungus Pichia guilliermondii Isolated from Paris polyphylla var. yunnanensis. Molecules. https://doi.org/10.3390/molecules15117961
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