Cytotoxicity and oral acute toxicity studies of Lantana camara leaf extract
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BACKGROUND: The objective of this study was to investigate the toxicity of Lantana camara methanol extract. METHODS: In order to evaluate the toxicity of Lantana camara, the acute toxicity of the methanolic extract on adult mice and cytotoxicity test on Vero cell line were investigated. A fixed large dose of 2 g/kg body weight of L. camara leaf extract was administrated by a single oral gavage according to the OECD procedure. RESULTS: In 2 weeks, L. camara leaf extract showed no obvious acute toxicity. While female mice lost body weight after being treated with single dose of leaf extract in acute toxicity test, male ones lost organ mass, particularly for heart and kidney. The biochemical liver function tests showed significantly elevated TBIL and ALT in the L. camara leaf extract treated female mice group compared with the control group. Cytotoxicity effect of leaf extract of L. camara was estimated through a MTT assay. Cytotoxicity tests on Vero cell line disclosed that leaf extract at concentrations up to 500 µg/mL inhibited the growth of cells 2.5 times less than did Triton 100 × 1%. More interestingly, the cytotoxicity initiated to decline at elevated concentrations of this extract. CONCLUSIONS: The results of both tests confirm that L. camara shows a pro toxic effect.
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PAG-based hydrogels up to 2 g/kg body weight caused no adverse effects on physical activities, general behavior, and growth of rabbits.
“These observations prove that there were no adverse effects on the physical activities, general behavior, and growth of rabbits treated with PAG-based hydrogels up to 2 g/kg body weight (Pour et al., 2011).”
From A novel pH-responsive hydrogel system based on Prunus armeniaca gum and acrylic acid: Preparation and evaluation as a potential candidate for controlled drug delivery. (2023) · cites this paper as Pour et al., 2011
The Experimental section (3.3) describes a 2,000 mg/kg dose of Lantana camara leaf extract given to mice, not PAG-based hydrogels given to rabbits. The Results section (2.1) reports observations in those mice; our copy does not address whether PAG-based hydrogels affect rabbits’ activity, behavior, or growth (searched: PAG-based hydrogels, rabbits, and growth). (LLM, conf=0.78)
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“These observations prove that there were no adverse effects on the physical activities, general behavior, and growth of rabbits treated with PAG-based hydrogels up to 2 g/kg body weight (Pour et al., 2011).”
Background
- Authors
- Pour, B. M., Latha, L. Y., & Sasidharan, S.
- Affiliations
- Department of Biotechnology, Faculty of Applied Sciences, AIMST University, Jalan Bedong-Semeling, Batu 3 ½, Bukit Air Nasi, Bedong 08100, Kedah, Malaysia
- Universiti Sains Malaysia (MY)
- Corresponding author
- Sasidharan, Sreenivasan
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2011-05-03
- Volume
- 16
- Issue
- 5
- Pages
- 3663-3674
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6263369
- OpenAlex
- W2119030936
- Cited by
- 83
- References
- 28
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 9 · 2023: 12 · 2022: 9 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 6 · 2012: 4
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Toxicity and Pharmacological Properties
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- Lantana camara, leaf extract, acute oral toxicity, cytotoxicity, Vero cells, hepatotoxicity, liver function tests, methanol extract, phytotoxicity, sex differences in toxicity
- MeSH terms
- Animals, Chlorocebus aethiops, Female, Heart, Kidney, Male, Plant Extracts, Vero Cells, Plant Leaves, Toxicity Tests, Acute, Lantana, Cell Proliferation, Mice
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