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Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components
Open accessAbstract
In this study, Rosmarinus officinalis L. essential oil and three of its main components 1,8-cineole (27.23%), α-pinene (19.43%) and β-pinene (6.71%) were evaluated for their in vitro antibacterial activities and toxicology properties. R. officinalis L. essential oil possessed similar antibacterial activities to α-pinene, and a little bit better than β-pinene, while 1,8-cineole possessed the lowest antibacterial activities. R. officinalis L. essential oil exhibited the strongest cytotoxicity towards three human cancer cells. Its inhibition concentration 50% (IC50) values on SK-OV-3, HO-8910 and Bel-7402 were 0.025‰, 0.076‰ and 0.13‰ (v/v), respectively. The cytotoxicity of all the test samples on SK-OV-3 was significantly stronger than on HO-8910 and Bel-7402. In general, R. officinalis L. essential oil showed greater activity than its components in both antibacterial and anticancer test systems, and the activities were mostly related to their concentrations.
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Cited by
Rašković, A., Milanović, I., Pavlović, N., Ćebović, T., Vukmirović, S., & Mikov, M. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-225 · Cited by 470
Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols
Moore, J., Yousef, M., & Tsiani, E. (2016) · Nutrients · doi:10.3390/nu8110731 · Cited by 292
Mena, P., Cirlini, M., Tassotti, M., Herrlinger, K., Dall’Asta, C., & Del Rio, D. (2016) · Molecules · doi:10.3390/molecules21111576 · Cited by 288
Ramadan, M. M., Ali, M. M., Ghanem, K. Z., & El-Ghorabe, A. H. (2015) · Grasas y Aceites · doi:10.3989/gya.0955142 · Cited by 38
Metadata
- Authors
- Wang, W., Li, N., Luo, M., Zu, Y., & Efferth, T.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2012-03-05
- Volume
- 17
- Issue
- 3
- Pages
- 2704-2713
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2108319118
- Cited by
- 266
- References
- 0
- FWCI
- 18.85
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wang, W., Li, N., Luo, M., Zu, Y., & Efferth, T. (2012). Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components. Molecules. https://doi.org/10.3390/molecules17032704
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