Berberine, an Epiphany Against Cancer

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Berberine induces apoptosis through a mitochondria/caspases pathway in human hepatoma cells

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Berberine Modifies Cysteine 179 of IκBα Kinase, Suppresses Nuclear Factor-κB–Regulated Antiapoptotic Gene Products, and Potentiates Apoptosis

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Berberine induces apoptosis in breast cancer cells (MCF-7) through mitochondrial-dependent pathway

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Berberine—antiproliferative activity in vitro and induction of apoptosis/necrosis of the U937 and B16 cells

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Berberine modulates AP-1 activity to suppress HPV transcription and downstream signaling to induce growth arrest and apoptosis in cervical cancer cells

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Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation

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Berberine and its derivatives: a patent review (2009 – 2012)

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Berberine hydrochloride: anticancer activity and nanoparticulate delivery system

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Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression

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Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL

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Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2

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p53 cooperates berberine‐induced growth inhibition and apoptosis of non‐small cell human lung cancer cells in vitro and tumor xenograft growth in vivo

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Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage

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Synergistic Tumor-Killing Effect of Radiation and Berberine Combined Treatment in Lung Cancer: The Contribution of Autophagic Cell Death

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Berberine Suppresses TNF-α-induced MMP-9 and Cell Invasion through Inhibition of AP-1 Activity in MDA-MB-231 Human Breast Cancer Cells

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Degradation of MDM2 by the Interaction between Berberine and DAXX Leads to Potent Apoptosis in MDM2-Overexpressing Cancer Cells

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Different concentrations of berberine result in distinct cellular localization patterns and cell cycle effects in a melanoma cell line

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The alkaloid Berberine inhibits the growth of Anoikis-resistant MCF-7 and MDA-MB-231 breast cancer cell lines by inducing cell cycle arrest

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Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth

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Berberine induced apoptosis via promoting the expression of caspase-8, -9 and -3, apoptosis-inducing factor and endonuclease G in SCC-4 human tongue squamous carcinoma cancer cells.

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Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor

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MicroRNA-21-3p, a Berberine-Induced miRNA, Directly Down-Regulates Human Methionine Adenosyltransferases 2A and 2B and Inhibits Hepatoma Cell Growth

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Set9, NF-κB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells

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Berberine inhibits p53-dependent cell growth through induction of apoptosis of prostate cancer cells

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Inhibition of Activator Protein 1 Activity by Berberine in Human Hepatoma Cells

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Berberine, a natural isoquinoline alkaloid, induces NAG-1 and ATF3 expression in human colorectal cancer cells

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Berberine Attenuates Experimental Autoimmune Encephalomyelitis in C57 BL/6 Mice

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Berberine inhibits p53-dependent cell growth through induction of apoptosis of prostate cancer cells.

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Anti-Inflammatory and Anticancer Drugs from Nature

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Berberine induces apoptosis through a mitochondrial/caspase pathway in human promonocytic U937 cells

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The combination of berberine and irradiation enhances anti‐cancer effects via activation of p38 MAPK pathway and ROS generation in human hepatoma cells

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Induction of Topoisomerase II-Mediated DNA Cleavage by a Protoberberine Alkaloid, Berberrubine

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Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147

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Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts

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Berberine Inhibits Metastasis of Nasopharyngeal Carcinoma 5-8F Cells by Targeting Rho Kinase-mediated Ezrin Phosphorylation at Threonine 567

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Anticancer bioactivity of compounds from medicinal plants used in European medieval traditions

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Enhancement of apoptosis of human hepatocellular carcinoma SMMC-7721 cells through synergy of berberine and evodiamine

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Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide

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Berberine Radiosensitizes Human Esophageal Cancer Cells by Downregulating Homologous Recombination Repair Protein RAD51

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Berberine inhibits human colon cancer cell migration via AMP-activated protein kinase-mediated downregulation of integrin β1 signaling

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Epithelial-to-mesenchymal transition markers to predict response of Berberine in suppressing lung cancer invasion and metastasis

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Effect of berberine on the antioxidant status, ultrastructural modifications and protein bound carbohydrates in azoxymethane-induced colon cancer in rats

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Berberine, an Isoquinoline Alkaloid, Inhibits the Metastatic Potential of Breast Cancer Cells via Akt Pathway Modulation

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TRAIL combinations: The new ‘trail’ for cancer therapy (Review)

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Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3.

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Berberine Induces G1 Arrest and Apoptosis in Human Glioblastoma T98G Cells through Mitochondrial/Caspases Pathway

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Berberine inhibits human neuroblastoma cell growth through induction of p53-dependent apoptosis.

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Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells

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Growth Suppression of HER2-Overexpressing Breast Cancer Cells by Berberine via Modulation of the HER2/PI3K/Akt Signaling Pathway

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AMP-activated protein kinase: An emerging target for ginseng

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Berberine sensitizes ovarian cancer cells to cisplatin through miR-21/PDCD4 axis

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Prevention and Treatment of Colorectal Cancer by Natural Agents from Mother Nature

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The Interaction of Telomeric DNA and C-myc22 G-Quadruplex with 11 Natural Alkaloids

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Berberine Protects against Palmitate-Induced Endothelial Dysfunction: Involvements of Upregulation of AMPK and eNOS and Downregulation of NOX4

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Berberine induces apoptosis via the mitochondrial pathway in liver cancer cells

YIP, N. K. Y., & Ho, W. S. (2013) · Oncology Reports · doi:10.3892/or.2013.2543 · Cited by 67

Multiple Effects of Berberine Derivatives on Colon Cancer Cells

Guamán‐Ortiz, L. M., Tillhon, M., Parks, M., Dutto, I., Prosperi, E., Savio, M., Arcamone, A. G., Buzzetti, F., Lombardi, P., & Scovassi, A. I. (2014) · BioMed Research International · doi:10.1155/2014/924585 · Cited by 66

Interaction of Herbal Compounds with Biological Targets: A Case Study with Berberine

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Berberine enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast cancer

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Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF-κB

Yu, M., Tong, X., Qi, B.-Q., Qu, H., Dong, S., Yu, B., ZHANG, N., Tang, N., Wang, L., & Zhang, C. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1762 · Cited by 60

BAG3 upregulates Mcl-1 through downregulation of miR-29b to induce anticancer drug resistance in ovarian cancer

杉尾, 明., Iwasaki, M., Habata, S., Mariya, T., Suzuki, M., Osogami, H., Tamate, M., Tanaka, R., & Saito, T. (2014) · Gynecologic Oncology · doi:10.1016/j.ygyno.2014.06.024 · Cited by 60

Antinociceptive effect of berberine on visceral hypersensitivity in rats

Tang, Q.-L. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i28.4582 · Cited by 58

Comprehensive Study in the Inhibitory Effect of Berberine on Gene Transcription, Including TATA Box

Wang, Y., Kheir, M. M., Chai, Y., Hu, J., Xing, D., Fan, L., & Du, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023495 · Cited by 56

Berberine, a Natural Product, Combined with Cisplatin Enhanced Apoptosis through a Mitochondria/Caspase-Mediated Pathway in HeLa Cells

Youn, M., So, H., Cho, H.-J., Kim, H.-J., Kim, Y., Lee, J., Sohn, J. S., Kim, Y. K., Chung, S.-Y., & Park, R. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.789 · Cited by 55

The dual behavior of PCSK9 in the regulation of apoptosis is crucial in Alzheimer’s disease progression (Review)

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Antitumor effect of novel berberine derivatives in breast cancer cells

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The 9-position in berberine analogs is an important determinant of DNA topoisomerase II inhibition.

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Berberine acts as a natural inhibitor of Wnt/β‐catenin signaling—Identification of more active 13‐arylalkyl derivatives

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Autophagy and Cancer

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Berberine Inhibits Pulmonary Metastasis through Down‐regulation of MMP in Metastatic B16F‐10 Melanoma Cells

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Down-Regulation of DNA Topoisomerase IIα in Human Colorectal Carcinoma Cells Resistant to a Protoberberine Alkaloid, Berberrubine

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Metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: an additional mechanism for the hypolipidemic effects of berberine

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Berberine Reduces the Metastasis of Chondrosarcoma by Modulating theαvβ3 Integrin and the PKCδ, c-Src, and AP-1 Signaling Pathways

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The Interplay of AMP-Activated Protein Kinase and Androgen Receptor in Prostate Cancer Cells

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The Combinational Effect of Vincristine and Berberine on Growth Inhibition and Apoptosis Induction in Hepatoma Cells

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