A survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2012
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Although considerable effort and progress has been made in the search for new anticancer drugs and treatments in the last several decades, cancer remains a major public health problem and one of the major causes of death worldwide. Many sources, including plants, animals, and minerals, are of interest in cancer research because of the possibility of identifying novel molecular therapeutics. Moreover, structure-activity-relationship (SAR) investigations have become a common way to develop naturally derived or semi-synthetic molecular analogues with improved efficacy and decreased toxicity. In 2012, approximately 138 molecules from marine sources, including isolated compounds and their associated analogues, were shown to be promising anticancer drugs. Among these, 62% are novel compounds. In this report, we review the marine compounds identified in 2012 that may serve as novel anticancer drugs.
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Multiple side effects have been reported with chemotherapy, motivating the search for other effective cure with fewer side effects.
“Despite the significant advances of current therapies [8,9], multiple side effects have been reported with chemotherapy [10], motivating the search for other effective cure with fewer side effects [10].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [10]
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- Authors
- Sawadogo, W., Boly, R., Cerella, C., Teiten, M., Dicato, M., & Diederich, M.
- Affiliations
- Hôpital Kirchberg (LU)
- Institut de Recherche en Sciences de la Santé (IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso
- Seoul National University (KR)
- Corresponding author
- Diederich, Marc
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2015-04-20
- Volume
- 20
- Issue
- 4
- Pages
- 7097-7142
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6272635
- OpenAlex
- W2917828788
- Cited by
- 49
- References
- 96
- Citations by year
- 2025: 6 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 9 · 2015: 2
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Deutsches Krebsforschungszentrum (2011-0030001)
- National Research Foundation (2011-0030001)
- Fonds National de la Recherche Luxembourg
- Ministry of Science, ICT and Future Planning (No. 2011-0030001, 2011‐0030001)
- National Research Foundation of Korea (2011‐0030001, No. 2011-0030001)
- Recherches Scientifiques Luxembourg
- Fondation Recherche Cancer et Sang
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Synthesis and Biological Activity
- Keywords
- marine natural products, anticancer activity, anticancer agents, structure-activity relationship, new compounds, marine organisms, cancer therapeutics
- MeSH terms
- Animals, Antineoplastic Agents, Biological Products, Humans, Marine Biology, Neoplasms, Structure-Activity Relationship, Molecular Structure, Drug Discovery
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