The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
The Potential of Cyclodextrins as Novel Active Pharmaceutical Ingredients: A Short Overview
Open accessAbstract
Cyclodextrins (CDs) are cyclic oligosaccharides of natural origin that were discovered more than 100 years ago. The peculiar cone-like conformation of the sugar ring, expressing a lipophilic cavity and a hydrophilic external surface, allows these substances to spontaneously complex poorly soluble compounds in an aqueous environment. For more than 50 years, these substances have found applicability in the pharmaceutical and food industries as solubilizing agents for poorly soluble chemical entities. Nowadays, several research groups all over the world are investigating their potential as active pharmaceutical ingredients (APIs) for the treatment of several illnesses (e.g., hypercholesterolemia, cancer, Niemann-Pick Type C disease). The aim of this review is to briefly retrace cyclodextrins’ legacy as complexing agents and describe the current and future prospects of this class of chemical entities in pharmaceutics as new APIs.
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Cites
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Connors, K. A. (1997) · Chemical Reviews · doi:10.1021/cr960371r · Cited by 2,175
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Cyclodextrins and their pharmaceutical applications
LOFTSSON, T., & DUCHENE, D. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.10.044 · Cited by 1,764
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Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
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Metadata
- Authors
- Di Cagno, M.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2016-12-25
- Volume
- 22
- Issue
- 1
- Pages
- 1
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2567425592
- Cited by
- 346
- References
- 52
- FWCI
- 20.26
- Type
- journal article
- Language
- en
- Open access
- gold
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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