Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application

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Items 101–200 of 305

1. Unlocking the Potential of Chemically Modified Nucleic Acid Therapeutics
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2. Inspirations of Biomimetic Affinity Ligands: A Review
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3. Aptamers: Features, Synthesis and Applications
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4. Types of RNA therapeutics
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5. EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment
   Debasmita Dutta, Ashique Al Hoque, Brahamacharry Paul, Jun Hyoung Park, Chinmay Chowdhury, Mohiuddin Quadir, Soumyabrata Banerjee, Arghadip Choudhury, Soumik Laha, Nayim Sepay et al. · 2024 · Journal of Biomedical Science
6. Modified DNA Aptamers for C-Reactive Protein and Lactate Dehydrogenase-5 with Sub-Nanomolar Affinities
   Hirotaka Minagawa, Yuka Kataoka, Hiroto Fujita, Masayasu Kuwahara, Katsunori Horii, Ikuo Shiratori, Iwao Waga · 2020 · International Journal of Molecular Sciences
7. Probing high-affinity aptamer binding region and development of aptasensor platform for the detection of cylindrospermopsin
   Raja Chinnappan, Razan AlZabn, Amjad K. Fataftah, Ali Alhoshani, Mohammed M. Zourob · 2020 · Analytical and Bioanalytical Chemistry
8. Aptamers for Proteins Associated with Rheumatic Diseases: Progress, Challenges, and Prospects of Diagnostic and Therapeutic Applications
   Elizaveta A. Shatunova, Maksim A. Korolev, Vitaly O. Omelchenko, Yu. D. Kurochkina, Anna Davydova, Alya G. Venyaminova, Mariya Vorobyeva · 2020 · Biomedicines
9. Classification of breast cancer by a gold nanoparticle based multicolor fluorescent aptasensor
   Yunyun Wu, Yuqing Feng, Xi Li · 2021 · Journal of Colloid and Interface Science
10. AS1411-functionalized delivery nanosystems for targeted cancer therapy
    Pooria Safarzadeh Kozani, Pouya Safarzadeh Kozani, Mohammad Tariq Malik · 2021 · Exploration of Medicine
11. Aptasensors for full body health checkup
    Tanu Bhardwaj, Tarun Kumar Sharma · 2022 · Biosensors and Bioelectronics X
12. Gold single atom-based aptananozyme as an ultrasensitive and selective colorimetric probe for detection of thrombin and C-reactive protein
    Gona K. Ali, Faisal K. Algethami, Khalid Mohammad Omer · 2023 · Microchimica Acta
13. Electrochemical cytosensors for non-invasive liquid biopsy: Detection procedures and technologies for circulating tumor cells
    Peilin Wu, Xun Jun He, Jiwen Fan, Yunze Tai, Dongdong Zheng, Yongchao Yao, Shengjun Sun, Yao Luo, Jie Chen, Wenchuang Walter Hu et al. · 2024 · Biosensors and Bioelectronics
14. Recent advances in aptamer-based biosensing technology for isolation and detection of extracellular vesicles
    Osama Abdulwahab Alnaser-Almusa, Mohammed Mahmoud, Mohammed Ilyas, Raghda Adwan, Farah Abul Rub, Noha Alnaser-Almusa, Fayrouz Mustafa, Sana G Ahmed, Alaa Alzhrani, Tanveer Ahmad Mir et al. · 2025 · Frontiers in Cell and Developmental Biology
15. New insights in aptamer-targeted nanoliposomes for the treatment of breast cancer
    Nidhi Jain Singhai, Rahul Maheshwari, Kapil Khatri · 2023 · Journal of Drug Delivery Science and Technology
16. Emerging perspectives on RNA virus-mediated infections: from pathogenesis to therapeutic interventions
    Pratik Mohanty, Poojarani Panda, Rakesh Kumar Acharya, Babita Pande, Lakkakula VKS Bhaskar, Henu Kumar Verma · 2023 · World Journal of Virology
17. Charge-Transfer Interactions Stabilize G-Quadruplex-Forming Thrombin Binding Aptamers and Can Improve Their Anticoagulant Activity
    Kévan Pérez de Carvasal, Claudia Riccardi, Irene Russo Krauss, Domenico Cavasso, Jean‐Jacques Vasseur, Michaël Smietana, F. Morvan, Daniela Montesarchio · 2021 · International Journal of Molecular Sciences
18. Aptamer Technology and Its Applications in Bone Diseases
    Xiangzhong Liu, Jing Hu, Yu Ning, Haijia Xu, Hantao Cai, Aofei Yang, Zheng-shuai Shi, Zhanghua Li · 2023 · Cell Transplantation
19. Selection of High-Affinity RNA Aptamers That Distinguish between Doxycycline and Tetracycline
    Zachary J. Tickner, Guocai Zhong, Kelly R. Sheptack, Michael Farzan · 2020 · Biochemistry
20. Effect of surface chemistry on bio-conjugation and bio-recognition abilities of 2D germanene materials
    Wei Li Ang, Jiří Šturala, Nikolas Antonatos, Zdeněk Sofer, Alessandra Bonanni · 2021 · Nanoscale
21. Selection and Characterization of Vimentin-Binding Aptamer Motifs for Ovarian Cancer
    Andrea M. Costello, Miguel-Ángel Elizondo-Riojas, Xin Li, David E. Volk, Anil Kumar Pillai, Hongyu Wang · 2021 · Molecules
22. Selection and characterization of a new human Interleukin-17A blocking DNA aptamer using protein-SELEX
    Saeideh Sadat Shobeiri, Kazem Mashayekhi, Motahare Khorrami, Malihe Moghadam, Mojtaba Sankian · 2022 · Biochemical and Biophysical Research Communications
23. Aptamers for the Delivery of Plant-Based Compounds: A Review
    Joana Gamboa, Pedro Lourenço, Carla Cruz, Eugénia Gallardo · 2024 · Pharmaceutics
24. X-aptamers targeting Thy-1 membrane glycoprotein in pancreatic ductal adenocarcinoma
    Hongyu Wang, Xin Li, Lisa Ann Lai, Teresa A. Brentnall, David W. Dawson, Kimberly A. Kelly, Ru Chen, Sheng Pan · 2020 · Biochimie
25. Continuous Detection of Increasing Concentrations of Thrombin Employing a Label-Free Photonic Crystal Aptasensor
    Paula Martínez-Pérez, M Gómez-Gómez, T. Angelova, Amadeu Griol, Juan Hurtado, Laurent Bellières, Jaime García‐Rupérez · 2020 · Micromachines
26. SOMAmer reagents and the SomaScan platform: Chemically modified aptamers and their applications in therapeutics, diagnostics, and proteomics
    Daniel J. Schneider, Sean A. Lynch, Amy D. Gelinas, Rachel M. Ostroff, John C. Rohloff, Preston Williams, Nebojša Janjić, Daniel W. Drolet · 2022 · Elsevier eBooks
27. One-pot rapid and ultrasensitive sensing strategy for endocrine disruptor bisphenol A using cationic AuNPs and aptamer
    Gurpreet K. Soni, Rohit Kumar Sharma · 2023 · Sensors and Actuators B Chemical
28. Remdesivir-Loaded Nanoliposomes Stabilized by Chitosan/Hyaluronic Acid Film with a Potential Application in the Treatment of Coronavirus Infection
    Viktoria Milkova, Neli Vilhelmova-Ilieva, Anna Y. Gyurova, Kamelia Kamburova, Ivaylo L. Dimitrov, Elina R. Tsvetanova, Almira P. Georgieva, Milka M. Mileva · 2023 · Neurology International
29. Cell-directed aptamer therapeutic targeting for cancers including those within the central nervous system
    Jun Wei, Renduo Song, Aria Sabbagh, Anantha Marisetty, Neal Shukla, Dexing Fang, Hinda Najem, Martina Ott, James Patrick Long, Lijie Zhai et al. · 2022 · OncoImmunology
30. Molecular regulation of hypoxia through the lenses of noncoding RNAs and epitranscriptome
    Safirul Islam, Chandrama Mukherjee · 2022 · Wiley Interdisciplinary Reviews - RNA
31. Application of multivalent aptamers in tumor diagnosis, analysis and therapy (Review)
    Hongyue Zeng, Wenjing Zeng, Yaoyao Liang · 2025 · Oncology Letters
32. Small RNA or oligonucleotide drugs and challenges in evaluating drug-drug interactions
    Joseph M. Cronin, Ai‐Ming Yu · 2025 · Frontiers in Pharmacology
33. RaptGen-Assisted Generation of an RNA/DNA Hybrid Aptamer against SARS-CoV-2 Spike Protein
    Tatsuo Adachi, Shigetaka Nakamura, Akiya Michishita, Daiki Kawahara, Mizuki Yamamoto, Michiaki Hamada, Yoshikazu Nakamura · 2024 · Biochemistry
34. Review—Aptamers and Biomimetic Receptors in Biosensing: Innovations and Applications
    Anjali Tripathi, Vinay Kumar Pandey, Hridyanshi Mishra, Sarvesh Rustagi, Aamir Hussain Dar, Sumira Malik · 2024 · Journal of The Electrochemical Society
35. Design of hybrid aptamer-molecularly imprinted polymer nanoparticles for selective binding of oxidized low-density lipoprotein in an ELISA-mimic system
    Suticha Chunta, Soemwit Khongwichit, Panwadee Wattanasin, Peter Alexander Lieberzeit, Maliwan Amatatongchai · 2025 · Talanta
36. Molecular Recognition: Perspective and a New Approach
    William Rudolf Seitz, Casey J. Grenier, John R. Csoros, Rongfang Yang, Tianyu Ren · 2021 · Sensors
37. AptaStrensor (aptamer-based sensor for stress monitoring): The interrelationship between NPY and cortisol towards chronic disease monitoring
    Nathan Kodjo Mintah Churcher, Cornelia Felicia Greyling, Sayali Upasham, Kai‐Chun Lin, Paul Rice, Madhavi L Pali, Joseph Charles Khavul Spiro, Shalini Prasad · 2022 · Biosensors and Bioelectronics X
38. Truncated Analogues of a G-Quadruplex-Forming Aptamer Targeting Mutant Huntingtin: Shorter Is Better!
    Claudia Riccardi, Federica D’Aria, D Fasano, Filomena Anna Digilio, Maria Rosaria Carillo, Jussara Amato, Laura De Rosa, Simona Paladino, Mariarosa Anna Beatrice Melone, Daniela Montesarchio et al. · 2022 · International Journal of Molecular Sciences
39. Recent Trends in Biosensors for Quinolone Detection: A Comprehensive Review
    Fabian Thurner, Fatima AlZahra’a Alatraktchi · 2023 · Chemosensors
40. Photoswitches for controllable RNA binding: a future approach in the RNA-targeting therapy
    Daria V. Berdnikova · 2021 · Chemical Communications
41. Advances in electrochemical aptasensing for cardiac biomarkers
    Md. Mahbubur Rahman, Nasrin Siraj Lopa, Jae‐Joon Lee · 2021 · Bulletin of the Korean Chemical Society
42. Artificial intelligence in the development of small nucleic acid therapeutics: toward smarter and safer medicines
    Pietro Delre, Carmen Cerchia, Antonio Lavecchia · 2025 · Drug Discovery Today
43. Assembling the RNA therapeutics toolbox
    Mona Teng, Ziting Judy Xia, Nicholas Lo, Kashif Daud, Housheng Hansen He · 2024 · Medical Review
44. An Antibody-Aptamer-Hybrid Lateral Flow Assay for Detection of CXCL9 in Antibody-Mediated Rejection after Kidney Transplantation
    Lisa K. Seiler, Ngoc Linh Phung, Christoph Nikolin, Stephan Immenschuh, Christian Erck, Jessica Katharina Kaufeld, Hermann G. Haller, Christine Susanne Falk, Rebecca Jonczyk, Patrick Lindner et al. · 2022 · Diagnostics
45. RETRACTED: Circularization enhances RNA aptamer binding and Stability: Evidence from in-cell NMR
    Omar Eladl · 2025 · Methods · Retracted
46. Recent Advances in Functionally Engineered Aptamers: Strategies and Applications
    Mengyue Liu, Shicai Xu, Yemin Guo, Xia Sun, Giovanna Marrazza · 2025 · Topics in Current Chemistry
47. Efficient Screening of Pesticide Diazinon-Binding Aptamers Using the Sol–Gel-Coated Nanoporous Membrane-Assisted SELEX Process and Next-Generation Sequencing
    Min‐Cheol Lim, Eun Seob Lim, Jeong-A Lim, Sung‐Wook Choi, Hyun‐Joo Chang · 2022 · Applied Biochemistry and Biotechnology
48. Variety of Nucleotide Polymerase Mutants Aiming to Synthesize Modified RNA
    Sana Ohashi, Fumitaka Hashiya, Hiroshi Abe · 2021 · ChemBioChem
49. Aptasensors Based on Track-Etched Membranes Coated with a Nanostructured Silver Layer for Influenza A and B Virus Detection
    Vladimir I. Kukushkin, Olga V. Kristavchuk, Gleb A. Zhdanov, Anna K. Keshek, Alexandra S. Gambaryan, Evgeny V. Andreev, Alexander N. Nechaev, Elena G. Zavyalova · 2023 · Bulletin of the Russian Academy of Sciences Physics
50. LPS-Induced Acute Lung Injury: Analysis of the Development and Suppression by the TNF-α-Targeting Aptamer
    Сенькова Александра Васильевна, Innokenty A. Savin, Elena L. Chernolovskaya, Anna Davydova, Mariya I. Meschaninova, Ali Bishani, Mariya Vorobyeva, Зенкова Марина Аркадьевна · 2024 · Acta Naturae
51. Aptamer-Based Immunotheranostic Strategies
    María Fernanda García Melián, María Moreno, Hugo Cerecetto, Victoria Calzada · 2023 · Cancer Biotherapy and Radiopharmaceuticals
52. Identification and characterization of aptameric inhibitors of human neutrophil elastase
    Stanisłąw Malicki, Mirosław Książęk, Alicja Sochaj Gregorczyk, Marta Kamińska, Anna Gołda, Barbara Chruścicka, Danuta Mizgalska, Jan Potempa, Hans‐Peter Marti, Joanna Kozieł et al. · 2023 · Journal of Biological Chemistry
53. Can Electrochemical Aptasensors Achieve the Commercial Success of Glucose Biosensors?
    Sina Ardalan, Anna Ignaszak · 2023 · Advanced Sensor Research
54. RaptScore: a large language model-based algorithm for versatile aptamer evaluation
    Akira Kimura-Yamazaki, Tatsuo Adachi, Shigetaka Nakamura, Yoshikazu Nakamura, Michiaki Hamada · 2025 · Nucleic Acids Research
55. Multisensors based on electrolyte-gated organic field-effect transistors (EGOFETs) with aptamers as recognition elements: current state of research
    Bogdan S. Kuleshov, Elena G. Zavyalova, Olena Yu. Poimanova, Anton A. Abramov, Sergey Anatol'evich Ponomarenko, Elena V. Agina · 2024 · Russian Chemical Reviews
56. Connective tissue growth factor-targeting DNA aptamer suppresses pannus formation as diagnostics and therapeutics for rheumatoid arthritis
    Gan Wu, Can Liu, Ben Cao, Zelin Cao, Haige Zhai, Bin Liu, Shengwei Jin, Xinyu Yang, Chen Lv, Jianguang Wang · 2022 · Frontiers in Immunology
57. Analysis of the Interaction between DNA Aptamers and Cytochrome C on the Surface of Lipid Films and on the MUA Monolayer: A QCM-D Study
    Marek Tatarko, Sandro Spagnolo, Martin Csiba, Veronika Šubjaková, Tibor Hianik · 2023 · Biosensors
58. Future Perspectives of Therapeutic, Diagnostic and Prognostic Aptamers in Eye Pathological Angiogenesis
    Emilio Iturriaga-Goyon, Beatriz Buentello‐Volante, Fátima Sofía Magaña‐Guerrero, Yonathan Garfias · 2021 · Cells
59. Exploring the diagnostic landscape: Portable aptasensors in point-of-care testing
    Anu Mohan, Ipsita Roy · 2025 · Analytical Biochemistry
60. Functional Aptamers In Vitro Evolution for Protein–Protein Interaction Blockage
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61. Systematic Review of Proteomics in Age-Related Macular Degeneration and Pathway Analysis of Significant Protein Changes
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62. Photoactivatable Aptamer-Based Biosensors for Point-of-Care Testing: Advances and Applications
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63. A review of targeted drug delivery with antibody-drug complexes
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64. Recent developments of nanomedicine delivery systems for the treatment of pancreatic cancer
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65. Therapeutic potential of extracellular vesicles in Parkinson’s disease
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66. Improving the Biological Properties of Thrombin-Binding Aptamer by Incorporation of 8-Bromo-2′-Deoxyguanosine and 2′-Substituted RNA Analogues
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67. Single-use biosensors for biomanufacturing: Perspective on the state-of-the-art
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68. In silico analysis of aptamer-RNA conjugate interactions with human transferrin receptor
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69. Recent advances in surface plasmon resonance for the detection of ovarian cancer biomarkers: a thorough review
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70. Aptamer-nanoconjugates as emerging theranostic systems in neurodegenerative disorders
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71. Anti‐CD63‐Oligonucleotide Functionalized Magnetic Beads for the Rapid Isolation of Small Extracellular Vesicles and Detection of EpCAM and HER2 Membrane Receptors using DARPin Probes
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72. Aptamer-regulated silver core-cuprous oxide shell nanozyme for surface-enhanced raman scattering and colorimetric dual-mode detection of kanamycin in food
    Xilai Ju, Guantong Liu, Xin Shun Sun, Haiyang Lv, Zhanye Yang, Shutong Zhang, Yuan Tian, Bing Zhao · 2026 · Food Chemistry
73. RNA aptamer-mediated gene therapy of prostate cancer: lessons from the past and future directions
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74. Advances in RNA therapeutics for modulation of ‘undruggable’ targets
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75. Molecular Mechanism of Interaction between DNA Aptamer and Receptor-Binding Domain of Severe Acute Respiratory Syndrome Coronavirus 2 Variants Revealed by Steered Molecular Dynamics Simulations
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76. Aptamers: ushering in new hopes in targeted glioblastoma therapy
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77. Selective Anti-melanoma Effect of Phosphothioated Aptamer Encapsulated by Neutral Cytidinyl/Cationic Lipids
    Jing Wu, Shuhe Wang, Xiang Li, Qi Zhang, Jie An Yang, Yuan Ma, Zhu Guan, Zhenjun Yang · 2021 · Frontiers in Cell and Developmental Biology
78. Analyzation of the binding mechanism and the isoelectric point of glycated albumin with self-assembled, aptamer-conjugated films by using surface plasmon resonance
    Dapeng Sun, Jing Xie, Ching-Jung Chen, Jen‐Tsai Liu · 2022 · Colloids and Surfaces B Biointerfaces
79. Novel Design of RNA Aptamers as Cancer Inhibitors and Diagnosis Targeting the Tyrosine Kinase Domain of the NT-3 Growth Factor Receptor Using a Computational Sequence-Based Approach
    Ashraf M. Muhammad, Ali Zari, Nouf H. Alsubhi, Maryam Hassan Al-Zahrani, Rana Abdullah Alghamdi, Mai M. Labib · 2022 · Molecules
80. bioTCIs: Middle-to-Macro Biomolecular Targeted Covalent Inhibitors Possessing Both Semi-Permanent Drug Action and Stringent Target Specificity as Potential Antibody Replacements
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81. High-throughput assays to assess variant effects on disease
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82. Innovative therapies for inherited retinal dystrophies: navigating DNA, RNA, and protein approaches
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83. Recent Advances in Cyanobacterial Cytotoxin Biosensors Focused on Cylindrospermopsin
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84. Hybridization liquid chromatography-mass spectrometry for quantitative bioanalysis of oligonucleotides: The upcoming paradigm shift
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85. Emerging Electrochemical and Biosensing Platforms for Troponin I and B-Type Natriuretic Peptide: A Comprehensive Insight into Next-Generation Cardiac Diagnostics
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86. Out of the dark: the emerging roles of lncRNAs in pain
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87. Emerging role and translational potential of small extracellular vesicles in neuroscience
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88. Origami-Inspired Biosensors: Exploring Diverse Applications and Techniques for Shape-Changing Sensor Platforms
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89. Synthesis and characterization of novel ssDNA X-aptamers targeting Growth Hormone Releasing Hormone (GHRH)
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90. Electrophoretic characterization of LNP/AAV‐encapsulated nucleic acids: Strengths and weaknesses
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91. Covalent labeling of immune cells
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92. Role of Natural Binding Proteins in Therapy and Diagnostics
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93. RNA-based therapies in hepatocellular carcinoma: state of the art and clinical perspectives
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94. Design of an innovative aptasensor for the detection of chemotherapeutic drug Fludarabine phosphate
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95. Aptamer Development for SARS-CoV-2 and Omicron Variants Using the Spike Protein Receptor Binding Domain as a Potential Diagnostic Tool and Therapeutic Agent
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96. Aptamer-based theranostic approaches for treatment of cancer
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97. Aptamer-guided Selective Delivery of Therapeutics to Breast Cancer Cells Expressing Specific Biomarkers
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98. EpCAM aptamer integrated graphene nanosystem for combined anti-ovarian cancer therapy
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99. Antitumor efficacy of multi-target in situ vaccinations with CpG oligodeoxynucleotides, anti-OX40, anti-PD1 antibodies, and aptamers
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100. Towards understanding the triggering of the malignant cell death in high-efficiency magneto-mechanical anticancer therapy
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