Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application

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Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery

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Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease

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2′-Fluoropyrimidine RNA-based Aptamers to the 165-Amino Acid Form of Vascular Endothelial Growth Factor (VEGF165)

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Surface plasmon resonance aptasensing and computational analysis of Staphylococcus aureus IsdA surface protein

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The Use of Thermal Dissociation for Selection of DNA Aptamers

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Interrogation of Small Molecules to Surface-Bound Aptamer Binding Kinetics with Electrochemical Aptamer-Based Sensors Using Intermittent Pulse Amperometry

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RNA therapeutics for metabolic disorders

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In silico selection of aptamers against SARS-CoV-2

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Novel paper sensor with modified aptamer for accurate detection of clinical cardiac troponin I

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Selection and Application of Aptamer Affinity for Protein Purification

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Potential use of SMART implants in traumatology and orthopedics: a review

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Next-generation electrochemical sensors for globally abused benzodiazepines: Carbon nanostructures paving the way for on-field applications

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Fulfilling multiple roles in PROTAC design: The emerging potential of oligonucleotides

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Illuminating the Invisible: Translational Molecular Imaging in Cardiovascular Medicine

Ma, Y., Sun, N., Fang, Y., Wang, Y., & Cao, F. (2026) · Circulation Research · doi:10.1161/circresaha.125.327199 · Cited by 3

Comparison of protein capture from a human cancer cell line by genomic G-quadruplex DNA sequences toward aptamer discovery

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Aptabinding of tumor necrosis factor‐α (TNFα) inhibits its proinflammatory effects and alleviates islet inflammation

Mahmoud, R., Kalivarathan, J., Castillo, A. J., Wang, S., Fuglestad, B., Kanak, M. A., & Dhakal, S. (2023) · Biotechnology Journal · doi:10.1002/biot.202300374 · Cited by 3

RNA therapeutics history and future perspectives

Duong, H., Hoang, M.-C., Nguyen, T.-H., Ngo, V.-L., & Le, V.-T. (2024) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2024.01.004 · Cited by 3

Development of novel DNA aptamers and colorimetric nanozyme aptasensor for targeting multi-drug-resistant, invasive Salmonella typhimurium strain SMC25

Joshi, A., Kaushik, A., Taneja, N. K., Chauhan, K., Kumar, A., & Sharma, T. K. (2024) · Biosensors and Bioelectronics X · doi:10.1016/j.biosx.2024.100555 · Cited by 3

DNA-Aptamer-Based qPCR Using Light-Up Dyes for the Detection of Nucleic Acids

Goyal, S., Singh, P., Sengupta, S., Muthukrishnan, A.-B., & Jayaraman, G. (2023) · ACS Omega · doi:10.1021/acsomega.3c07599 · Cited by 3

Aptamer-Based Switching System for Communication of Non-Interacting Proteins

Kim, Y., Nam, D., Lee, E. S., Kim, S., Cha, B. S., & Park, K. S. (2024) · Biosensors · doi:10.3390/bios14010047 · Cited by 3

Multiple Myeloma: Therapeutic Delivery of Antibodies and Aptamers

Pujol-Navarro, N., Qaraghuli, M. M. A., Kubiak-Ossowska, K., Alsaadi, M., Horne, G. A., Soutar, R. L., Paspali, E., Ferro, V. A., Williams, M. T. S., & Mulheran, P. A. (2021) · Therapeutic Delivery · doi:10.4155/tde-2021-0041 · Cited by 3

Development of Specific Inhibitors for Oncogenic Phosphatase PPM1D by Using Ion-Responsive DNA Aptamer Library

Kaneko, A., Watari, M., Mizunuma, M., Saito, H., Furukawa, K., & Chuman, Y. (2020) · Catalysts · doi:10.3390/catal10101153 · Cited by 3

Target-induced recycling and self-folding hairpin primer-mediated LAMP activation of CRISPR/Cas12a for highly sensitive aptamer-based therapeutic antibody assay

Shi, K., Zhang, J., Yuan, R., & Xiang, Y. (2025) · The Analyst · doi:10.1039/d5an00458f · Cited by 2

Employing covalent organic framework (COF) as carrier in an aptamer-targeted theranostic nanoplatform: investigation of its therapeutic and diagnostic properties in vitro and in vivo

Moghadam, S. M. M., Ramezani, M., Alibolandi, M., Abnous, K., & Taghdisi, S. M. (2025) · Journal of drug targeting · doi:10.1080/1061186x.2025.2527865 · Cited by 3

Metallic Nanoparticles and Carbon-Based Materials for the Fabrication of Electrochemical Biosensors aiming the Mycotoxin Analysis in Food

Baccaro, A., Cardoso, P., Píccoli, R. H., Bufalo, T. C. E., Martins, R. C., Vilela, T., Alves, A. C., Pereira, L., & Felix, F. S. (2025) · Brazilian Journal of Analytical Chemistry · doi:10.30744/brjac.2179-3425.rv-189-2024 · Cited by 2

Engineered RNA Devices for In Vivo Targeted Therapeutics via Advanced Delivery Systems

Luo, W., Liu, X., Han, Y., Duan, Y., Yu, C., Kong, N., & Xie, T. (2025) · Aggregate · doi:10.1002/agt2.70191 · Cited by 2

Atomic resolution mapping and electrochemical analysis of illicit drug-aptamer complexes and their terahertz signatures

Qureshi, J. A., Abdollahi, G., & Tabib‐Azar, M. (2025) · IEEE Nanotechnology Materials and Devices Conference (NMDC) · doi:10.1109/nmdc64551.2025.11234005 · Cited by 2

Aptasensors in colorectal Cancer: Emerging tools for precision diagnostics

Abuhassan, Q., Atoom, A. M., Roopashree, R., Kanwar, J. B., Sudhakar, T., Sharma, V., Chauhan, A. S., & Ruziyev, O. (2025) · Clinica Chimica Acta · doi:10.1016/j.cca.2025.120751 · Cited by 2

RNA sample preparation strategies for mass spectrometry sequencing of the epitranscriptome and therapeutic RNAs: A review

Fitzgerald, N. J., Huang, W., & Clark, K. D. (2026) · Analytica Chimica Acta · doi:10.1016/j.aca.2026.345154 · Cited by 2

Aptamer-integrated nanoplatforms for water safety: a focus on heavy metals, antibiotics, pesticides, and bacterial pathogens

Uğurlu, Ö., Gök, O., Ülker, G., Soytürk, H., Özyurt, C., & Evran, S. (2026) · Discover Molecules · doi:10.1007/s44345-025-00044-6 · Cited by 2

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Best, N., Karabiyik, G., Geerling, G., Zwingelberg, S. B., Lang, G., & Humeník, M. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.202505182 · Cited by 2

Aptamer-mediated inhibition of cellular apoptosis and ROS induced by the p54 protein of African swine fever virus

Bora, N. R., Kumar, R., Kumar, S., & Kumar, S. (2026) · Microbial Pathogenesis · doi:10.1016/j.micpath.2026.108669 · Cited by 2

Oligonucleotide Complexes in Bioorganometallic Chemistry

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Whole Cell Yeast-Based Biosensors

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Generation of DNA-aptamers targeting galectin-7 for the identification of cholesteatoma residue

Liu, S., Takemasa, E., Suzuki, Y., Javkhlant, A., Takagi, T., Yamada, H., Abe, Y., Hato, N., & Mogi, M. (2022) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2022.08.002 · Cited by 2

Mesyl Phosphoramidate Oligonucleotides: A New Promising Type of Antisense Agents

Stetsenko, D. A. (2023) · Springer eBooks · doi:10.1007/978-981-19-9776-1_19 · Cited by 2

Targeting strategies using gold nanoparticles for efficient drug delivery

Wheate, N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19061-2.00016-x · Cited by 2

Breaking Barriers: Nucleic Acid Aptamers in Gastrointestinal (GI) Cancers Therapy

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Research progress on the application of magnetophoretic separation technology in detection of food quality

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Study on the detection of antibiotics in food based on enzyme - free labelless aptamer sensor

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Current status in clinical advancement of RNA therapeutics – Correspondence

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RNA therapeutics for β-thalassemia

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A novel platform for metabolomics using barcoded structure-switching aptamersPreprint

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Elucidating the stabilization mechanism of a K+-depleted c-MYC DNA G-quadruplex in hydrophobic imidazolium-based ionic liquids using spectroscopy coupled with molecular dynamics simulations

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Antithrombotic but not anticoagulant activity of the thrombin‐binding RNA aptamer Apta‐1

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Exploring Molecular Binding: A Fluorescence Anisotropy Lab for Undergraduates

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Aptamer-based Biosensors for Monitoring Food Quality and Safety

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Aptamers: A Novel Class of Targeted Therapeutics

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Harnessing sustainability in the development of flexible, wearable sensors for the low molecular weight protein detection

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Engineering PEGylated dendrimers for targeted Cancer nanomedicine: From molecular design to therapeutic application

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Aptamers targeting immune checkpoints for tumor immunotherapy: a comprehensive review

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Facile synthesis of tunable zinc–adenine frameworks for aptamer-based biological applications

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Surface-Tailored Nanocarrier Drug Delivery Systems: Emerging Tools for HIV Management

Gupta, K., Mukherjee, A., & Kumar, S. (2026) · BioNanoScience · doi:10.1007/s12668-026-02543-3 · Cited by 1

Molecular Engineering of Aptamers for Glioblastoma Therapy: From Simple Antagonists to AI-Driven Approaches, a Narrative Review

Leandro, L. D., Colasante, M., Catanesi, M., Giansanti, F., Cimini, A., d’Angelo, M., Castelli, V., Savino, R., & Ippoliti, R. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27188231 · Cited by 1

Lagerstroemia indica methanolic extract alleviates CCl4-induced liver toxicity via modulation of Nrf2 signaling pathway in rats

Nisar, J., Sarwar, M., Shah, S., Yasmin, S., Farooq, H., Moin, H., & Mustafa, I. (2025) · Asian Pacific Journal of Tropical Biomedicine · doi:10.4103/apjtb.apjtb_202_25 · Cited by 1

Recent advances in the analysis of the evolutionary RNA based therapeutics; a review

Khalil, H. A., El-Sayed, N. W., Elmoslhy, R. M., & El-Yazbi, A. F. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.150466 · Cited by 1

A Target-Displaced Aptamer–cDNA Duplex Strategy on ERGO for Ultrasensitive Turn-On Electrochemical Detection of Ochratoxin A

Gita, L. I., Jang, S. J., & Kim, T. H. (2026) · Sensors · doi:10.3390/s26061937 · Cited by 1

Mesyl Phosphoramidate Oligonucleotides: A New Promising Type of Antisense Agents

Stetsenko, D. A. (2023) · Springer eBooks · doi:10.1007/978-981-16-1313-5_19-1 · Cited by 1

Programmable stopped-flow injection analysis: A comparative study on the effects of adenosine and its aptamer on respiratory burst of salivary and circulatory neutrophils

Liang, X., He, C., & Shen, H. (2024) · Talanta · doi:10.1016/j.talanta.2024.125672 · Cited by 1

Origin of ribonucleotide recognition motifs through ligand mimicry at early earth

Mozumdar, D., & Roy, R. N. (2024) · RNA Biology · doi:10.1080/15476286.2024.2423149 · Cited by 1

Apta-Nanobiosensors in Precision Agriculture: Methods and Applications

Gogoi, R., Daimari, F. S., Sarma, H. H., Rath, A., Sharma, M. R., Anshu, Barooah, M., & Bora, S. S. (2025) · Sustainability Sciences in Asia and Africa · doi:10.1007/978-981-96-8335-2_6 · Cited by 1

Challenges and Limitations in Aptamer-Based Cancer Diagnosis and Therapy

Nangare, S., Pawara, D. L., & Tade, R. S. (2025) · Springer eBooks · doi:10.1007/978-981-96-8387-1_12 · Cited by 1

Aptasensors based on track-etched membranes coated with nanostructured silver layer for influenza A and B virus detection

Kukushkin, V. I., Kristavchuk, O. V., Zhdanov, G. A., Keshek, A. K., Gambaryan, A. S., Andreev, Y. V., Nechaev, A. N., & Zavyalova, E. G. (2023) · Известия Российской академии наук Серия физическая · doi:10.31857/s0367676522700375 · Cited by 1

Aptamers in Diagnosis and Therapeutics Against the Antimicrobial-Resistant Microorganisms: Recent Trends and Challenges

Moulick, U. G., & Bhattacharjee, S. (2020) · Bioanalysis · doi:10.4155/bio-2020-0099 · Cited by 1

Dynamic and Mechanical Applications of DNA Nanostructures in Biophysics

Shahhosseini, M., Kucinic, A., Beshay, P. E., Pfeifer, W. G., & Castro, C. E. (2022) · Wiley eBooks · doi:10.1002/9781119682561.ch5 · Cited by 1

Ultrahigh-throughput discovery of modified aptamers as specific and potent enzyme inhibitorsPreprint

Husser, C., Hoetzel, J., Cubí, R., Lebars, I., Kraus, L., Primo, C. D., Baudrey, S., Proschak, E., Kieffer, B., Suess, B., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.16.608213 · Cited by 1

Nanomaterials-based electrochemical and optical biosensors for food safety regulations and point-of-care diagnosis

Ang, W. L. (2021) · doi:10.32657/10356/155394

Synthesis and characteristics of fluorescent red-emitting DNA-templated silver nanoclusters based on aptamer selected to lung cancer

Chumakov, D. S., Kichkailo, A. S., Сергеевна, З. Г., Буров, А. М., & Khlebtsov, N. G. (2022) · Computational Biophysics and Nanobiophotonics · doi:10.1117/12.2626120

Introduction to a review series on RNA therapeutics in hematology

Gotlib, J. R. (2023) · Blood · doi:10.1182/blood.2023020910

Cyanotoxins availability and detection methods in wastewater treatment plants: A review

Manjitha, K. G. L., & Sewwandi, B. G. N. (2023) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2023.106886

RNA therapeutics in hematology

Mandal, P. K. (2024) · Journal of Hematology and Allied Sciences · doi:10.25259/jhas_5_2024

Membrane Chromatographic Test System for Determining Bisphenol A in Drinking Water Based on the Use of an Aptamer

Komova, N. S., Serebrennikova, K. V., Berlina, A. N., Zherdev, A. V., & Dzantiev, B. B. (2024) · Journal of Analytical Chemistry · doi:10.1134/s1061934824040099

Inhibition of coagulation factor XI/XIa - the next step in increasing the safety of anticoagulant therapy?

Bultas, J. (2024) · Vnitřní lékařství · doi:10.36290/vnl.2024.043

Complement and Complement-Mediated Toxicity

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Current and Future of Complement Therapeutics and their Impact on the Clinical Immunology Laboratory

Dixon, B. P., Purohit, S., & Frazer‐Abel, A. A. (2024) · Wiley eBooks · doi:10.1002/9781683674023.ch12

Membrane chromatographic test system for the determination of bisphenol A in drinking water based on the use of an aptamer

Komova, N. S., Serebrennikova, K. V., Berlina, A. N., Zherdev, A. V., & Dzantiev, B. B. (2024) · Journal of Analytical Chemistry · doi:10.31857/s0044450224050116

Hepatoprotective Potential of Eremanthin by Modulating Keap1/Nrf2/ARE Signaling in CCl 4 -Induced Liver ToxicityPreprint

Mustafa, I., Iqbal, M. K., Khan, B., Khan, H., Shahab, S., Shah, U. D., Kiyani, M. M., Haq, B. U., Bashir, S., & Nisar, J. (2025) · Research Square · doi:10.21203/rs.3.rs-6318491/v1

Aptasensors

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Nucleic Acid-Based Systems for Regenerative Medicine

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Avacincaptad pegol, the second approved aptamer medicine – A mini review

Bege, M., Kattoub, R. G., & Borbás, A. (2025) · De Remediis · doi:10.71116/8n3dc940

Competitive Fluorescence Polarization Aptamer Analysis of Aflatoxin B1: Influence of the Salt Composition of the Reaction Medium on the Interaction of Reagents and the Detection Limit

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Influence of the polycation structure on the physicochemical and biological properties of polyplex of heparin and aptamers systems

Tymecka, M., Skóra, M., Bonarek, P., Rajtar, N., & Kamiński, K. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.115269

Additional file 1 of EpCAM-targeted betulinic acid analogue nanotherapy improves therapeutic efficacy and induces anti-tumorigenic immune response in colorectal cancer tumor microenvironment

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Aptamers as immunomodulatory therapeutic alternatives targeting neglected tropical diseases (NTDs)

Silva, L. R., Silva, W. F. D. S., de Melo, A. C. F., Rodrigues, É. E. D. S., & da Silva-Júnior, E. F. (2026) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2026.02.010

Development of synthetic RNA using ultrahigh-throughput microfluidic screening

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