RETRACTED: Therapeutic Effects of Gallic Acid in Regulating Senescence and Diabetes; an In Vitro Study
Open accessAbstract
Gallic acid (GA), a plant-derived ubiquitous secondary polyphenol metabolite, can be a useful dietary supplement. This in vitro study’s primary purpose was to assess the anti-aging properties of GA using rat embryonic fibroblast (REF) cells, antidiabetic effects via pancreatic islet cells, and finally, elucidating the molecular mechanisms of this natural compound. REF and islet cells were isolated from fetuses and pancreas of rats, respectively. Then, several senescence-associated molecular and biochemical parameters, along with antidiabetic markers, were investigated. GA caused a significant decrease in the β-galactosidase activity and reduced inflammatory cytokines and oxidative stress markers in REF cells. GA reduced the G0/G1 phase in senescent REF cells that led cells to G2/M. Besides, GA improved the function of the β cells. Flow cytometry and spectrophotometric analysis showed that it reduces apoptosis via inhibiting caspase-9 activity. Taken together, based on the present findings, this polyphenol metabolite at low doses regulates different pathways of senescence and diabetes through its antioxidative stress potential and modulation of mitochondrial complexes activities.
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GA can reduce senescence markers in rat embryonic fibroblast cells, delay thymus involution in old mice, and protect cardiac cells from oxidative damage and senescence, enhancing GST expression.
“Indeed, it has been shown that GA can reduce senescence markers in rat embryonic fibroblast cells, delay thymus involution in old mice, and protect cardiac cells from oxidative damage and senescence, enhancing GST expression [296,323,353].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [323]
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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
- Authors
- Rahimifard, M., Baeeri, M., Bahadar, H., Moini-Nodeh, S., Khalid, M., Haghi-Aminjan, H., Mohammadian, H., & Abdollahi, M.
- Affiliations
- Pharmaceutical Sciences Research Center (IR)
- Khyber Medical University (PK)
- Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran 1417613151, Iran
- Pharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil 5618953141, Iran
- Corresponding author
- Baeeri, Maryam
- Abdollahi, Mohammad
- ORCID
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2020-12-11
- Volume
- 25
- Issue
- 24
- Pages
- 5875
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC7763304
- OpenAlex
- W3110672190
- Cited by
- 61
- References
- 52
- Citations by year
- 2026: 3 · 2025: 15 · 2024: 13 · 2023: 8 · 2022: 11 · 2021: 11
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute for Medical Research Development (NIMAD) (971478)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- gallic acid, cellular senescence, diabetes mellitus, anti-aging, rat embryonic fibroblasts, pancreatic islet cells, beta-cell function, oxidative stress, inflammation, apoptosis, caspase-9, G0/G1 cell cycle arrest, mitochondrial function, polyphenols
- MeSH terms
- Animals, Antioxidants, beta-Galactosidase, Cell Cycle, Diabetes Mellitus, Fibroblasts, Flow Cytometry, Gallic Acid, Inflammation, Islets of Langerhans, Spectrophotometry, Cellular Senescence, Apoptosis, Oxidative Stress, Rats, Caspase 9, Polyphenols, In Vitro Techniques
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