The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants
Open accessAbstract
Heavy metals, which have widespread environmental distribution and originate from natural and anthropogenic sources, are common environmental pollutants. In recent decades, their contamination has increased dramatically because of continuous discharge in sewage and untreated industrial effluents. Because they are non-degradable, they persist in the environment; accordingly, they have received a great deal of attention owing to their potential health and environmental risks. Although the toxic effects of metals depend on the forms and routes of exposure, interruptions of intracellular homeostasis include damage to lipids, proteins, enzymes and DNA via the production of free radicals. Following exposure to heavy metals, their metabolism and subsequent excretion from the body depends on the presence of antioxidants (glutathione, α-tocopherol, ascorbate, etc.) associated with the quenching of free radicals by suspending the activity of enzymes (catalase, peroxidase, and superoxide dismutase). Therefore, this review was written to provide a deep understanding of the mechanisms involved in eliciting their toxicity in order to highlight the necessity for development of strategies to decrease exposure to these metals, as well as to identify substances that contribute significantly to overcome their hazardous effects within the body of living organisms.
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Cites
Free radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680
Metals, Toxicity and Oxidative Stress
Valko, M., Morris, H., & Cronin, M. (2005) · Current Medicinal Chemistry · doi:10.2174/0929867053764635 · Cited by 5,018
[1] Role of free radicals and catalytic metal ions in human disease: An overview
Halliwell, B., & Gutteridge, J. M. C. (1990) · Methods in Enzymology · doi:10.1016/0076-6879(90)86093-b · Cited by 4,994
Heavy metals, occurrence and toxicity for plants: a review
Nagajyoti, P. C., Lee, K. D., & Sreekanth, T. V. M. (2010) · Environmental Chemistry Letters · doi:10.1007/s10311-010-0297-8 · Cited by 3,962
Oxidative DNA damage: mechanisms, mutation, and disease
Cooke, M. S., Evans, M. D., Dizdaroglu, M., & Lunec, J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0752rev · Cited by 3,245
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
Szabó, C., Ischiropoulos, H., & Radi, R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2222 · Cited by 2,134
The toxicology of mercury—current exposures and clinical manifestations
Clarkson, T. W., Magos, L., & Myers, G. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022471 · Cited by 1,766
Naujokas, M. F., Anderson, B., Ahsan, H., Aposhian, H. V., Graziano, J. H., Thompson, C., & Suk, W. A. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1205875 · Cited by 1,372
Base-excision repair of oxidative DNA damage
David, S. S., O'Shea, V. L., & Kundu, S. (2007) · Nature · doi:10.1038/nature05978 · Cited by 1,238
Reactions of oxyl radicals with DNA
Breen, A. P., & Murphy, J. A. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00209-3 · Cited by 1,038
Cited by
Sharifi-Rad, M., Anil Kumar, N. V., Zucca, P., Varoni, E. M., Dini, L., Panzarini, E., Rajkovic, J., Tsouh Fokou, P. V., Azzini, E., Peluso, I., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00694 · Cited by 1,971
The essential metals for humans: a brief overview
Zoroddu, M. A., Aaseth, J., Crisponi, G., Medici, S., Peana, M., & Nurchi, V. M. (2019) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2019.03.013 · Cited by 1,085
Dash, U. C., Bhol, N. K., Swain, S. K., Samal, R. R., Nayak, P. K., Raina, V., Panda, S. K., Kerry, R. G., Duttaroy, A. K., & Jena, A. B. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.10.004 · Cited by 700
Edible insects as future food: chances and challenges
Lange, K. W., & Nakamura, Y. (2021) · Journal of Future Foods · doi:10.1016/j.jfutfo.2021.10.001 · Cited by 344
Toxicity of heavy metals in plants and animals and their uptake by magnetic iron oxide nanoparticles
Rehman, A. U., Nazir, S., Irshad, R., Tahir, K., ur Rehman, K., Islam, R. U., & Wahab, Z. (2021) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.114455 · Cited by 322
Metadata
- Authors
- Jan, A., Azam, M., Siddiqui, K., Ali, A., Choi, I., & Haq, Q.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2015-12-10
- Volume
- 16
- Issue
- 12
- Pages
- 29592-29630
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2195785268
- Cited by
- 1,225
- References
- 18
- FWCI
- 16.09
- Type
- journal article
- Language
- en
- Open access
- gold
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- Jan, A., Azam, M., Siddiqui, K., Ali, A., Choi, I., & Haq, Q. (2015). Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms161226183
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