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Cited by 418Antimicrobial agents and applicationsEssential Oils and Antimicrobial ActivityBioactive natural compounds

Future Antimicrobials: Natural and Functionalized Phenolics

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Lobiuc, Andrei, Pavăl, Naomi-Eunicia, Mangalagiu, Ionel I., Gheorghiță, Roxana, Teliban, Gabriel-Ciprian, Amăriucăi-Mantu, Dorina, Stoleru, Vasile·2023·Molecules
DOI 10.3390/molecules28031114PMC PMC9920704
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Abstract

With incidence of antimicrobial resistance rising globally, there is a continuous need for development of new antimicrobial molecules. Phenolic compounds having a versatile scaffold that allows for a broad range of chemical additions; they also exhibit potent antimicrobial activities which can be enhanced significantly through functionalization. Synthetic routes such as esterification, phosphorylation, hydroxylation or enzymatic conjugation may increase the antimicrobial activity of compounds and reduce minimal concentrations needed. With potent action mechanisms interfering with bacterial cell wall synthesis, DNA replication or enzyme production, phenolics can target multiple sites in bacteria, leading to a much higher sensitivity of cells towards these natural compounds. The current review summarizes some of the most important knowledge on functionalization of natural phenolic compounds and the effects on their antimicrobial activity.

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  • The finding that the strongest antimicrobial effect occurred at 40 °C for 60 minutes correlates strongly with the trends seen for TPC and DPPH antioxidant activity, reinforcing the role of phenolic compounds as key contributors to antimicrobial efficacy.

    “This finding correlates strongly with the trends seen for TPC and DPPH antioxidant activity, reinforcing the role of phenolic compounds as key contributors to antimicrobial efficacy (Manso et al., 2022; Lobiuc et al., 2023).”

    From Influence of Extraction Parameters on Bioactive Compounds and Antimicrobial Activity of Banana Peel Using Ethanol-Water Solvent (2026) · cites this paper as Lobiuc et al., 2023

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  • Phenolic compounds exert antimicrobial effects through a diverse array of mechanisms that target key structural and functional components of microbial cells.

    “Phenolic compounds exert antimicrobial effects through a diverse array of mechanisms that target key structural and functional components of microbial cells.”

    From Influence of Extraction Parameters on Bioactive Compounds and Antimicrobial Activity of Banana Peel Using Ethanol-Water Solvent (2026) · cites this paper as Lobiuc et al., 2023

  • Some phenolic compounds interfere directly with microbial nucleic acids by intercalating between DNA bases or inducing oxidative damage, thereby impairing replication and transcription processes.

    “Moreover, some phenolic compounds interfere directly with microbial nucleic acids by intercalating between DNA bases or inducing oxidative damage, thereby impairing replication and transcription processes (Lobiuc et al., 2023).”

    From Influence of Extraction Parameters on Bioactive Compounds and Antimicrobial Activity of Banana Peel Using Ethanol-Water Solvent (2026) · cites this paper as Lobiuc et al., 2023

  • Phenolics can disrupt bacterial cell walls and membranes by interacting with lipid bilayers and membrane proteins, causing increased permeability, leakage of cellular contents, and ultimately cell death.

    “Primarily, these compounds can disrupt bacterial cell walls and membranes by interacting with lipid bilayers and membrane proteins, causing increased permeability, leakage of cellular contents, and ultimately cell death (Lobiuc et al., 2023).”

    From Influence of Extraction Parameters on Bioactive Compounds and Antimicrobial Activity of Banana Peel Using Ethanol-Water Solvent (2026) · cites this paper as Lobiuc et al., 2023

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  1. [1]Rana A. Samtiya M. Dhewa T. Mishra V. Aluko R.E. Health benefits of polyphenols: A concise review J. Food Biochem. 2022 46 e14264 10.1111/jfbc.14264 35694805 · DOI
  2. [3]Olszowy M. What is responsible for antioxidant properties of polyphenolic compounds from plants? Plant Physiol. Biochem. 2019 144 135 143 10.1016/j.plaphy.2019.09.039 31563754 · DOI
  3. [4]Bors W. Michel C. Chemistry of the Antioxidant Effect of Polyphenols Ann. New York Acad. Sci. 2002 957 57 69 10.1111/j.1749-6632.2002.tb02905.x 12074961 · DOI
  4. [5]Makarewicz M. Drożdż I. Tarko T. Duda-Chodak A. The Interactions between Polyphenols and Microorganisms, Especially Gut Microbiota Antioxidants 2021 10 188 10.3390/antiox10020188 33525629 PMC7911950 · DOI
  5. [6]Belščak-Cvitanović A. Durgo K. Huđek A. Bačun-Družina V. Komes D. Overview of polyphenols and their properties Polyphenols: Properties, Recovery, and Applications Galanakis C.M. Woodhead Publishing Sawston, UK 2018 3 44 10.1016/b978-0-12-813572-3.00001-4 · DOI
  6. [7]Bouarab-Chibane L. Forquet V. Lantéri P. Clément Y. Léonard-Akkari L. Oulahal N. Degraeve P. Bordes C. Antibacterial Properties of Polyphenols: Characterization and QSAR (Quantitative Structure–Activity Relationship) Models Front. Microbiol. 2019 10 829 10.3389/fmicb.2019.00829 31057527 PMC6482321 · DOI
  7. [8]Xie Y. Chen J. Xiao A. Liu L. Antibacterial Activity of Polyphenols: Structure-Activity Relationship and Influence of Hyperglycemic Condition Molecules 2017 22 1913 10.3390/molecules22111913 29113147 PMC6150409 · DOI
  8. [9]Xiao J. Ni X. Kai G. Chen X. A Review on Structure–Activity Relationship of Dietary Polyphenols Inhibiting α-Amylase Crit. Rev. Food Sci. Nutr. 2013 53 497 506 10.1080/10408398.2010.548108 23391016 · DOI
  9. [10]Friedman M. Henika P.R. Mandrell R.E. Antibacterial Activities of Phenolic Benzaldehydes and Benzoic Acids against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica J. Food Prot. 2003 66 1811 1821 10.4315/0362-028X-66.10.1811 14572218 · DOI
  10. [11]Cushnie T.P.T. Lamb A.J. Recent advances in understanding the antibacterial properties of flavonoids Int. J. Antimicrob. Agents 2011 38 99 107 10.1016/j.ijantimicag.2011.02.014 21514796 · DOI
  11. [12]Kawaguchi Y. Yamauchi S. Masuda K. Nishiwaki H. Akiyama K. Maruyama M. Sugahara T. Kishida T. Koba Y. Antimicrobial Activity of Stereoisomers of Butane-Type Lignans Biosci. Biotechnol. Biochem. 2009 73 1806 1810 10.1271/bbb.90167 19661689 · DOI
  12. [13]Kumar S.N. Siji J.V. Nambisan B. Mohandas C. Activity and synergistic interactions of stilbenes and antibiotic combinations against bacteria in vitro World J. Microbiol. Biotechnol. 2012 28 3143 3150 10.1007/s11274-012-1124-0 22806752 · DOI
  13. [14]Farha A.K. Yang Q.-Q. Kim G. Li H.-B. Zhu F. Liu H.-Y. Gan R.-Y. Corke H. Tannins as an alternative to antibiotics Food Biosci. 2020 38 100751 10.1016/j.fbio.2020.100751 · DOI
  14. [15]Rispail N. Morris P. Webb K.J. Phenolic Compounds: Extraction and analysis Lotus Japonicus Handbook Springer Berlin/Heidelberg, Germany 2006 349 354 10.1007/1-4020-3735-x_34 · DOI
  15. [16]Banjarnahor S.D.S. Artanti N. Antioxidant properties of flavonoids Med. J. Indones. 2015 23 239 244 10.13181/mji.v23i4.1015 · DOI
  16. [18]Saltveit M.E. Synthesis and Metabolism of Phenolic Compounds Fruit and Vegetable Phytochemicals Wiley-Blackwell Oxford, UK 2009 89 100 10.1002/9780813809397.ch3 · DOI
  17. [19]de la Rosa L.A. Moreno-Escamilla J.O. Rodrigo-García J. Alvarez-Parrilla E. Phenolic Compounds Postharvest Physiology and Biochemistry of Fruits and Vegetables Elsevier Amsterdam, The Netherlands 2019 253 271
  18. [20]Zhang Y. Wei J. Qiu Y. Niu C. Song Z. Yuan Y. Yue T. Structure-Dependent Inhibition of Stenotrophomonas maltophilia by Polyphenol and Its Impact on Cell Membrane Front. Microbiol. 2019 10 2646 10.3389/fmicb.2019.02646 31798564 PMC6863799 · DOI
  19. [21]Sánchez-Maldonado A. Schieber A. Gänzle M. Structure-function relationships of the antibacterial activity of phenolic acids and their metabolism by lactic acid bacteria J. Appl. Microbiol. 2011 111 1176 1184 10.1111/j.1365-2672.2011.05141.x 21895894 · DOI
  20. [22]Pernin A. Guillier L. Dubois-Brissonnet F. Inhibitory activity of phenolic acids against Listeria monocytogenes: Deciphering the mechanisms of action using three different models Food Microbiol. 2019 80 18 24 10.1016/j.fm.2018.12.010 30704593 · DOI
  21. [23]Cueva C. Moreno-Arribas M.V. Martín-Álvarez P.J. Bills G. Vicente M.F. Basilio A. Rivas C.L. Requena T. Rodríguez J.M. Bartolomé B. Antimicrobial activity of phenolic acids against commensal, probiotic and pathogenic bacteria Res. Microbiol. 2010 161 372 382 10.1016/j.resmic.2010.04.006 20451604 · DOI
  22. [24]Kahkeshani N. Farzaei F. Fotouhi M. Alavi S.S. Bahramsoltani R. Naseri R. Momtaz S. Abbasabadi Z. Rahimi R. Farzaei M.H. Pharmacological effects of gallic acid in health and disease: A mechanistic review Iran. J. Basic. Med. Sci. 2019 22 225 237 10.22038/IJBMS.2019.32806.7897 31156781 PMC6528712 · DOI
  23. [25]Borges A. Ferreira C. Saavedra M.J. Simões M. Antibacterial Activity and Mode of Action of Ferulic and Gallic Acids Against Pathogenic Bacteria Microb. Drug Resist. 2013 19 256 265 10.1089/mdr.2012.0244 23480526 · DOI
  24. [26]Kouassi Y. Shelef L.A. Inhibition of Listeria Monocytogenes by Cinnamic Acid: Possible Interaction of the Acid with Cysteinyl Residues J. Food Saf. 1998 18 231 242 10.1111/j.1745-4565.1998.tb00217.x · DOI
  25. [27]Lou Z. Wang H. Rao S. Sun J. Ma C. Li J. p-Coumaric acid kills bacteria through dual damage mechanisms Food Control. 2012 25 550 554 10.1016/j.foodcont.2011.11.022 · DOI
  26. [28]Oteiza P.I. Erlejman A.G. Verstraeten S.V. Keen C.L. Fraga C.G. Flavonoid-membrane Interactions: A Protective Role of Flavonoids at the Membrane Surface? Clin. Dev. Immunol. 2005 12 19 25 10.1080/10446670410001722168 15712595 PMC2270717 · DOI
  27. [29]Kumar S. Pandey A.K. Chemistry and Biological Activities of Flavonoids: An Overview Sci. World J. 2013 2013 162750 10.1155/2013/162750 24470791 PMC3891543 · DOI
  28. [30]Renzetti A. Betts J.W. Fukumoto K. Rutherford R.N. Antibacterial green tea catechins from a molecular perspective: Mechanisms of action and structure–activity relationships Food Funct. 2020 11 9370 9396 10.1039/D0FO02054K 33094767 · DOI
  29. [31]Abuga I. Sulaiman S.F. Wahab R.A. Ooi K.L. Rasad M.S.B.A. In vitro antibacterial effect of the leaf extract of Murraya koenigii on cell membrane destruction against pathogenic bacteria and phenolic compounds identification Eur. J. Integr. Med. 2020 33 101010 10.1016/j.eujim.2019.101010 · DOI
  30. [32]Khameneh B. Iranshahy M. Soheili V. Bazzaz B.S.F. Review on plant antimicrobials: A mechanistic viewpoint Antimicrob. Resist. Infect. Control. 2019 8 1 28 10.1186/s13756-019-0559-6 31346459 PMC6636059 · DOI
  31. [33]Rafał I.G. Króliczewski B.J. Górniak I. Bartoszewski R. Króliczewski Á.J. Comprehensive review of antimicrobial activities of plant flavonoids Phytochem. Rev. 2018 18 10471 10.1007/s11101-018-9591-z · DOI
  32. [34]Yuan G. Guan Y. Yi H. Lai S. Sun Y. Cao S. Antibacterial activity and mechanism of plant flavonoids to gram-positive bacteria predicted from their lipophilicities Sci. Rep. 2021 11 10471 10.1038/s41598-021-90035-7 34006930 PMC8131645 · DOI
  33. [35]Tsou L.K. Lara-Tejero M. RoseFigura J. Zhang Z.J. Wang Y.-C. Yount J.S. Lefebre M. Dossa P.D. Kato J. Guan F. Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates J. Am. Chem. Soc. 2016 138 2209 2218 10.1021/jacs.5b11575 26847396 PMC4831573 · DOI
  34. [36]Chen C.-C. Huang C.-Y. Inhibition of Klebsiella Pneumoniae DnaB Helicase by the Flavonol Galangin Protein J. 2011 30 59 65 10.1007/s10930-010-9302-0 21210194 · DOI
  35. [37]Biharee A. Sharma A. Kumar A. Jaitak V. Antimicrobial flavonoids as a potential substitute for overcoming antimicrobial resistance Fitoterapia 2020 146 104720 10.1016/j.fitote.2020.104720 32910994 · DOI
  36. [38]McGillick B.E. Kumaran D. Vieni C. Swaminathan S. β-Hydroxyacyl-acyl Carrier Protein Dehydratase (FabZ) from Francisella tularensis and Yersinia pestis: Structure Determination, Enzymatic Characterization, and Cross-Inhibition Studies Biochemistry 2016 55 1091 1099 10.1021/acs.biochem.5b00832 26818694 · DOI
  37. [39]Lee H. Ji Y.R. Ryoo Z.Y. Choi M.-S. Woo E.-R. Lee D.G. Antibacterial Mechanism of (−)-Nortrachelogenin in Escherichia coli O157 Curr. Microbiol. 2016 72 48 54 10.1007/s00284-015-0918-3 26420306 · DOI
  38. [40]Zhou H. Ren J. Li Z. Antibacterial activity and mechanism of pinoresinol from Cinnamomum Camphora leaves against food-related bacteria Food Control. 2017 79 192 199 10.1016/j.foodcont.2017.03.041 · DOI
  39. [41]Favela-Hernández J.M.J. García A. Garza-González E. Rivas-Galindo V.M. Camacho-Corona M.R. Antibacterial and Antimycobacterial Lignans and Flavonoids from Larrea tridentata Phytotherapy Res. 2012 26 1957 1960 10.1002/ptr.4660 22422605 · DOI
  40. [42]Taylor E.J.M. Yu Y. Champer J. Kim J. Resveratrol Demonstrates Antimicrobial Effects Against Propionibacterium acnes In Vitro Dermatol Ther (Heidelb). 2014 4 249 257 10.1007/s13555-014-0063-0 25228291 PMC4257953 · DOI
  41. [43]Tan S. Hua X. Xue Z. Ma J. Cajanin Stilbene Acid Inhibited Vancomycin-Resistant Enterococcus by Inhibiting Phosphotransferase System Front. Pharmacol. 2020 11 473 10.3389/fphar.2020.00473 32372958 PMC7179074 · DOI
  42. [44]Chung K.-T. Lu Z. Chou M. Mechanism of inhibition of tannic acid and related compounds on the growth of intestinal bacteria Food Chem. Toxicol. 1998 36 1053 1060 10.1016/S0278-6915(98)00086-6 9862646 · DOI
  43. [45]Engels C. Gänzle M.G. Schieber A. Fractionation of Gallotannins from Mango (Mangifera indica L.) Kernels by High-Speed Counter-Current Chromatography and Determination of Their Antibacterial Activity J. Agric. Food Chem. 2010 58 775 780 10.1021/jf903252t 20020695 · DOI
  44. [46]Lakey-Beitia J. Burillo A.M. La Penna G. Hegde M.L. Rao K. Polyphenols as Potential Metal Chelation Compounds Against Alzheimer’s Disease J. Alzheimer’s Dis. 2021 82 S335 S357 10.3233/JAD-200185 32568200 PMC7809605 · DOI
  45. [47]Tintino S.R. Morais-Tintino C.D. Campina F.F. Costa M.D.S. Menezes I.R. de Matos Y.M.L. Calixto-Júnior J.T. Pereira P.S. Siqueira-Junior J.P. Leal-Balbino T.C. Tannic acid affects the phenotype of Staphylococcus aureus resistant to tetracycline and erythromycin by inhibition of efflux pumps Bioorganic Chem. 2017 74 197 200 10.1016/j.bioorg.2017.08.004 28841421 · DOI
  46. [48]Olchowik-Grabarek E. Sękowski S. Kwiatek A. Płaczkiewicz J. Abdulladjanova N. Shlyonsky V. Swiecicka I. Zamaraeva M. The Structural Changes in the Membranes of Staphylococcus aureus Caused by Hydrolysable Tannins Witness Their Antibacterial Activity Membranes 2022 12 1124 10.3390/membranes12111124 36363679 PMC9698758 · DOI
  47. [49]Li X. He C. Song L. Li T. Cui S. Zhang L. Jia Y. Antimicrobial activity and mechanism of Larch bark procyanidins against Staphylococcus aureus Acta Biochim. et Biophys. Sin. 2017 49 1058 1066 10.1093/abbs/gmx112 29095973 · DOI
  48. [50]Wishart D.S. Feunang Y.D. Guo A.C. Lo E.J. Marcu A. Grant J.R. Sajed T. Johnson D. Li C. Sayeeda Z. DrugBank 5.0: A major update to the DrugBank database for 2018 Nucleic Acids Res. 2018 46 D1074 D1082 10.1093/nar/gkx1037 29126136 PMC5753335 · DOI · Paper page
  49. [51]Silhavy T.J. Kahne D. Walker S. The Bacterial Cell Envelope Cold Spring Harb. Perspect. Biol. 2010 2 a000414 10.1101/cshperspect.a000414 20452953 PMC2857177 · DOI
  50. [52]Efenberger-Szmechtyk M. Nowak A. Czyzowska A. Plant extracts rich in polyphenols: Antibacterial agents and natural preservatives for meat and meat products Crit. Rev. Food Sci. Nutr. 2021 61 149 178 10.1080/10408398.2020.1722060 32043360 · DOI
  51. [53]Zhang Q. Zhang J. Zhang J. Xu D. Li Y. Liu Y. Zhang X. Zhang R. Wu Z. Weng P. Antimicrobial Effect of Tea Polyphenols against Foodborne Pathogens: A Review J. Food Prot. 2021 84 1801 1808 10.4315/JFP-21-043 34086921 · DOI
  52. [54]Guo L. Sun Q. Gong S. Bi X. Jiang W. Xue W. Fei P. Antimicrobial Activity and Action Approach of the Olive Oil Polyphenol Extract Against Listeria monocytogenes Front. Microbiol. 2019 10 1586 10.3389/fmicb.2019.01586 31396167 PMC6663969 · DOI
  53. [55]Piekarska-Radzik L. Klewicka E. Mutual influence of polyphenols and Lactobacillus spp. bacteria in food: A review Eur. Food Res. Technol. 2021 247 9 24 10.1007/s00217-020-03603-y · DOI
  54. [56]Lin S. Wang Z. Lam K.-L. Zeng S. Tan B.K. Hu J. Role of intestinal microecology in the regulation of energy metabolism by dietary polyphenols and their metabolites Food Nutr. Res. 2019 63 1518 10.29219/fnr.v63.1518 30814920 PMC6385797 · DOI
  55. [57]Othman L. Sleiman A. Abdel-Massih R.M. Antimicrobial Activity of Polyphenols and Alkaloids in Middle Eastern Plants Front. Microbiol. 2019 10 911 10.3389/fmicb.2019.00911 31156565 PMC6529554 · DOI
  56. [58]Kardum N. Glibetic M. Polyphenols and Their Interactions with Other Dietary Compounds: Implications for Human Health. 2018, 84, 103–144 10.1016/bs.afnr.2017.12.001 29555067 · DOI
  57. [59]Röttig A. Steinbüchel A. Acyltransferases in Bacteria Microbiol. Mol. Biol. Rev. 2013 77 277 321 10.1128/MMBR.00010-13 23699259 PMC3668668 · DOI
  58. [60]Yilmaz H. Subasi B.G. Celebioglu H.U. Ozdal T. Capanoglu E. Chemistry of Protein-Phenolic Interactions Toward the Microbiota and Microbial Infections Front. Nutr. 2022 9 914118 10.3389/fnut.2022.914118 35845785 PMC9284217 · DOI
  59. [61]Hossain M.A. Lee S.J. Park N.H. Mechesso A.F. Birhanu B.T. Kang J. Reza A. Suh J.W. Park S.C. Impact of phenolic compounds in the acyl homoserine lactone-mediated quorum sensing regulatory pathways Sci. Rep. 2017 7 10618 10.1038/s41598-017-10997-5 28878346 PMC5587592 · DOI
  60. [62]Alvarado-Martinez Z. Bravo P. Kennedy N.-F. Krishna M. Hussain S. Young A.C. Biswas D. Antimicrobial and Antivirulence Impacts of Phenolics on Salmonella Enterica Serovar Typhimurium Antibiotics 2020 9 668 10.3390/antibiotics9100668 33022945 PMC7600263 · DOI
  61. [63]Tapiero H. Tew K. Ba G.N. Mathé G. Polyphenols: Do they play a role in the prevention of human pathologies? Biomed. Pharmacother. 2002 56 200 207 10.1016/S0753-3322(02)00178-6 12109813 · DOI
  62. [64]Teng H. Chen L. Polyphenols and bioavailability: An update Crit. Rev. Food Sci. Nutr. 2019 59 2040 2051 10.1080/10408398.2018.1437023 29405736 · DOI
  63. [65]D’Archivio M. Filesi C. Varì R. Scazzocchio B. Masella R. Bioavailability of the Polyphenols: Status and Controversies Int. J. Mol. Sci. 2010 11 1321 1342 10.3390/ijms11041321 20480022 PMC2871118 · DOI · Paper page
  64. [66]Tarko T. Duda-Chodak A. Zajac N. Digestion and absorption of phenolic compounds assessed by in vitro simulation methods. A review Rocz. Panstw. Zakl. Hig. 2013 64 79 84 23987074
  65. [67]Balzerani F. Hinojosa-Nogueira D. Cendoya X. Blasco T. Pérez-Burillo S. Apaolaza I. Francino M.P. Rufián-Henares J. Planes F.J. Prediction of degradation pathways of phenolic compounds in the human gut microbiota through enzyme promiscuity methods NPJ Syst. Biol. Appl. 2022 8 24 10.1038/s41540-022-00234-9 35831427 PMC9279433 · DOI
  66. [68]Domínguez-Avila J.A. Wall-Medrano A. Velderrain-Rodríguez G. Chen C.-Y.O. Salazar-López N.J. Robles-Sánchez M. González-Aguilar G.A. Gastrointestinal interactions, absorption, splanchnic metabolism and pharmacokinetics of orally ingested phenolic compounds Food Funct. 2017 8 15 38 10.1039/C6FO01475E 28074953 · DOI
  67. [69]Merkl R. Hrádková I. Filip V. Šmidrkal J. Antimicrobial and antioxidant properties of phenolic acids alkyl esters Czech J. Food Sci. 2010 28 275 279 10.17221/132/2010-CJFS · DOI
  68. [70]Wang Y. Xie M. Ma G. Fang Y. Yang W. Ma N. Fang D. Hu Q. Pei F. The antioxidant and antimicrobial activities of different phenolic acids grafted onto chitosan Carbohydr. Polym. 2019 225 115238 10.1016/j.carbpol.2019.115238 31521271 · DOI · Paper page
  69. [71]Osorio M. Carvajal M. Vergara A. Butassi E. Zacchino S. Mascayano C. Montoya M. Mejías S. Martín M. Vásquez-Martínez Y. Prenylated Flavonoids with Potential Antimicrobial Activity: Synthesis, Biological Activity, and In Silico Study Int. J. Mol. Sci. 2021 22 5472 10.3390/ijms22115472 34067346 PMC8196815 · DOI
  70. [72]Shamsudin N.F. Ahmed Q.U. Mahmood S. Shah S.A.A. Khatib A. Mukhtar S. Alsharif M.A. Parveen H. Zakaria Z.A. Antibacterial Effects of Flavonoids and Their Structure-Activity Relationship Study: A Comparative Interpretation Molecules 2022 27 1149 10.3390/molecules27041149 35208939 PMC8879123 · DOI
  71. [73]Osonga F.J. Onyango J.O. Mwilu S.K. Noah N.M. Schulte J. An M. Sadik O.A. Synthesis and characterization of novel flavonoid derivatives via sequential phosphorylation of quercetin Tetrahedron Lett. 2017 58 1474 1479 10.1016/j.tetlet.2017.02.085 · DOI
  72. [74]Osonga F.J. Akgul A. Miller R.M. Eshun G.B. Yazgan I. Akgul A. Sadik O.A. Antimicrobial Activity of a New Class of Phosphorylated and Modified Flavonoids ACS Omega 2019 4 12865 12871 10.1021/acsomega.9b00077 31460413 PMC6681995 · DOI
  73. [75]Kopacz M. Quercetin- and Morinsulfonates as Analytical Reagents J. Anal. Chem. 2003 58 225 229 10.1023/A:1022630319311 · DOI
  74. [77]Tago R. Yamauchi S. Maruyama M. Akiyama K. Sugahara T. Kishida T. Koba Y. Structure-Antibacterial Activity Relationship for 9-O,9′-O-Demethyl (+)-virgatusin Biosci. Biotechnol. Biochem. 2008 72 1032 1037 10.1271/bbb.70783 18391445 · DOI
  75. [78]Albert S. Horbach R. Deising H.B. Siewert B. Csuk R. Synthesis and antimicrobial activity of (E) stilbene derivatives Bioorganic Med. Chem. 2011 19 5155 5166 10.1016/j.bmc.2011.07.015 21803587 · DOI
  76. [79]Singh D. Chauhan N. Koli M. Nayak S.K. Subramanian M. Dimer stilbene, a resveratrol analogue exhibits synergy with antibiotics that target protein synthesis in eradicating Staphylococcus aureus infection Biochimie 2022 201 128 138 10.1016/j.biochi.2022.06.006 35772578 · DOI
  77. [80]Kim T. Silva J. Kim M. Jung Y. Enhanced antioxidant capacity and antimicrobial activity of tannic acid by thermal processing Food Chem. 2010 118 740 746 10.1016/j.foodchem.2009.05.060 · DOI
  78. [81]Widsten P. Heathcote C. Kandelbauer A. Guebitz G. Nyanhongo G.S. Prasetyo E.N. Kudanga T. Enzymatic surface functionalisation of lignocellulosic materials with tannins for enhancing antibacterial properties Process. Biochem. 2010 45 1072 1081 10.1016/j.procbio.2010.03.022 · DOI

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Authors
Lobiuc, A., Pavăl, N.-E., Mangalagiu, I. I., Gheorghiță, R., Teliban, G.-C., Amăriucăi-Mantu, D., & Stoleru, V.
Affiliations
  • Ştefan cel Mare University of Suceava (RO)
  • Alexandru Ioan Cuza University (RO)
  • Faculty of Medicine and Biological Sciences, “Ştefan cel Mare” University, 720229 Suceava, Romania
  • "Ion Ionescu de la Brad" Iasi University of Life Sciences (RO)
Corresponding author
  • Pavăl, Naomi-Eunicia
  • Mangalagiu, Ionel I.
ORCID
Venue
Molecules
Publisher
MDPI AG
Published
2023-01-22
Volume
28
Issue
3
Pages
1114
ISSN
1420-3049 (ISSN-L)
DOI
10.3390/molecules28031114
PMC
PMC9920704
OpenAlex
W4317721583
Cited by
418
References
1
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FWCI
10.27
Type
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Language
en
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  • Molecules (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Ministry of Research, Innovation and Digitization, CCCDI-UEFISCDI (PN-III-P2-2.1-PED-2021-4380)
Topics
  • Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
Keywords
phenolic compounds, antimicrobial activity, antimicrobial resistance, chemical functionalization, esterification, phosphorylation, hydroxylation, enzymatic conjugation, bacterial cell wall synthesis, DNA replication inhibition, enzyme inhibition, natural products
MeSH terms
Anti-Infective Agents, Anti-Bacterial Agents, Antioxidants, Phenols, Plant Extracts

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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