Biodegradable Redox-Sensitive Star Polymer Nanomicelles for Enhancing Doxorubicin Delivery
Open accessAbstract
A typical amphiphilic star polymer adamantane-[poly(lactic-co-glycolic acid)-bis(2-carboxyethyl) sulfide-poly(ethylene glycol) monomethyl ether)]4 with a specific hydrophilic/redox-sensitive/hydrophobic structure was designed and synthesized through ring opening and esterification reactions. The self-assembled nanomicelles were used as doxorubicin (DOX) delivery vehicles with suitable critical micelle concentrations (5.0 mg/L). After the drug being loaded, drug-loaded micelles showed good drug-loading efficiency (10.39%), encapsulation efficiency (58.1%), and drug release (up to 60%) under simulated biological environment conditions. In addition, the backbone structure of the biodegradable polymer was easily hydrolyzed by the action of biological enzymes. As expected, cell-based studies showed that the designed polymer micelles possessed good biocompatibility (a survival rate of 85% for NH-3T3 cells). Moreover, the drug (DOX) still maintained good anti-cancer effects after being loaded, which caused 40% of MCF-7 cells to survive. These redox-sensitive micelles showed anti-tumor therapeutic potential.
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Selective delivery is achieved via novel design of various stimuli-responsive nanomicelles that release drugs based on endogenous or exogenous stimulations such as pH, temperature, ultrasound, light, redox potential, and others.
“Selective delivery is achieved via novel design of various stimuli-responsive nanomicelles that release drugs based on endogenous or exogenous stimulations such as pH, temperature, ultrasound, light, redox potential, and others.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [20]
The Introduction (page not provided) describes drug-loaded micelles accumulating at tumor sites and releasing drugs in response to pH, redox conditions, or light. The Conclusions (page not provided) report redox-triggered doxorubicin release from the micelles studied. Our copy does not support the claim’s additional examples of temperature- or ultrasound-triggered release. (LLM, conf=0.87)
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- Authors
- Li, M., Guo, J.-W., Wen, W.-Q., & Chen, J.-K.
- Affiliations
- Guangdong University of Technology (CN)
- School of Chemical Engineering & Light Industry, Guangdong University of Technology, Guangzhou 510006, China
- National Taiwan University of Science and Technology (TW)
- Corresponding author
- Chen, Jem-Kun
- Venue
- Nanomaterials
- Publisher
- MDPI AG
- Published
- 2019-04-04
- Volume
- 9
- Issue
- 4
- Pages
- 547
- ISSN
- 2079-4991 (ISSN-L)
- PMC
- PMC6523129
- OpenAlex
- W2932384298
- Cited by
- 15
- References
- 34
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2021: 7 · 2020: 4 · 2019: 1
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nanomaterials (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Science and Technology Program of Guangzhou City; National Natural Science Foundation of China ((No. 201704030075); (No. 21476051))
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- doxorubicin, poly(lactic-co-glycolic acid), PEG, adamantane, self-assembly, biodegradable polymers, enzymatic hydrolysis, biocompatibility, MCF-7 cells, anticancer drug delivery
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