Effects of synbiotics among constipated adults in Serdang, Selangor, Malaysia-a randomised, double-blind, placebo-controlled trial
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Synbiotics approach complementarily and synergistically toward the balance of gastrointestinal microbiota and improvement in bowel functions. A randomised, double-blind, placebo-controlled study was conducted to examine the effects of a synbiotics supplement among constipated adults. A total of 85 constipated adults, diagnosed by Rome III criteria for functional constipation were randomised to receive either synbiotics (n = 43) or placebo (n = 42) once daily (2.5 g) in the morning for 12 weeks. Eight times of follow-up was conducted every fortnightly with treatment response based on a questionnaire that included a record of evacuation (stool frequency, stool type according to Bristol Stool Form Scale), Patients Assessment on Constipation Symptoms (PAC-SYM), and Patients Assessment on Constipation Quality of Life (PAC-QOL). There were no significant differences in stool evacuation, but defecation frequency and stool type in treatment group were improved tremendously than in placebo group. While the treatment group was reported to have higher reduction in severity of functional constipation symptoms, the differences were not statistically significant. Dietary supplementation of synbiotics in this study suggested that the combination of probiotics and prebiotics improved the functional constipation symptoms and quality of life although not significant. This was due to the high placebo effect which synbiotics failed to demonstrate benefit over the controls.
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In another randomized, double-blind, placebo-controlled trial with a larger sample size, no significant effect was found for a synbiotic composed of B. lactis BB12, L. plantarum LP01, and inulin-oligofructose.
“However, in another randomized, double-blind, placebo-controlled trial with a larger sample size, no significant effect was found for a synbiotic composed of B . lactis BB12, L . plantarum LP01, and inulin-oligofructose [ 96 ].”
From Role of gut microbiota in functional constipation (2021) · cites this paper as [96]
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- Authors
- Lim, Y. J., Jamaluddin, R., Hazizi, A. S., & Chieng, J. Y.
- Affiliations
- Universiti Putra Malaysia (MY)
- Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
- Corresponding author
- Jamaluddin, Rosita
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2018-06-26
- Volume
- 10
- Issue
- 7
- Pages
- 824
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC6073678
- OpenAlex
- W2811102433
- Cited by
- 37
- References
- 61
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 1 · 2023: 7 · 2022: 7 · 2021: 5 · 2020: 2 · 2019: 4
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- European Food Safety Authority
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- synbiotics, functional constipation, probiotics, prebiotics, dietary supplementation, bowel function, stool frequency, stool consistency, constipation symptoms, quality of life, placebo effect, gut microbiota
- MeSH terms
- Gastrointestinal Microbiome, Adult, Constipation, Defecation, Double-Blind Method, Female, Gastrointestinal Motility, Humans, Intestines, Malaysia, Male, Quality of Life, Time Factors, Treatment Outcome, Recovery of Function, Young Adult, Synbiotics, Patient Outcome Assessment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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